[1]丛悦,陈肖华,祝鑫瑜.S100A8与辐射相关性的研究进展[J].国际放射医学核医学杂志,2007,31(3):182-184.
 CONG Yue,CHEN Xiao-hua,ZHU Xin-yu.Progress on the relativity between gene S100A8 and radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):182-184.
点击复制

S100A8与辐射相关性的研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第3期
页码:
182-184
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress on the relativity between gene S100A8 and radiation
作者:
丛悦 陈肖华 祝鑫瑜
100850 北京, 军事医学科学院放射医学研究所急性放射病损伤治疗研究室
Author(s):
CONG Yue CHEN Xiao-hua ZHU Xin-yu
Department of Acate Radiation Sickness, Beijing Institute of Radiation Medicine, Beijing 100850, China
关键词:
辐射效应紫外线基因S100A8
Keywords:
Radiation effectsUltraviolet raysGeneS100A8
分类号:
Q691
摘要:
S100A8钙结合蛋白是高度保守的、低分子质量的酸性蛋白,具有多种生理学功能.小鼠S100A8蛋白对于骨髓细胞是一种很强的化学诱导剂,参与众多的急性和慢性炎性反应,并与癌症的发生密切相关,S100A8基因的失活可导致胚胎死亡.在MCF-7细胞、表皮细胞以及骨髓等组织中,辐射可以诱导S100A8基因的表达,由此确定S100A8基因是新的辐射诱导基因.
Abstract:
S100A8 calcium-binding protein is highly conserved, low-molecular-weight acidic protein with important functions. Murine S100A8 is a potent chemoattractant for myeloid cells, and has been associated with a number of acute and chronic inflammatory conditions. Inactivation of the SI00A8 gene is embryonic lethal. Evidence has indicated that ionizing radiation can induce expression of S100A8 gene, so we confirm that S100A8 gene is a new radiation-induced gene.

参考文献/References:

1 饶亚岚,陈肖华,张军权.SSH方法分析大剂量照射后小鼠骨髓差异表达EST序列.中华放射医学与防护杂志,2003,23(3):163-166.
2 Grimbaldeston MA,Geczy CL,Tedla N,et al.S100A8 induction in keratinocytes by ultraviolet A irradiation is dependent on reactive oxygen intermediates.J Invest Dermatol,2003,121(5):1168-1174.
3 Xu K,Yen T,Geczy CL.I1-10 up-regulates macrophage expression of the S100 protein S100A8.J Immunol,2001,166(10):6358-6366.
4 Devery JM,King NJ,Geezy CL.Acute inflammatory activity of the S100 protein CP-10.Activation of neutrophils in vion and in vitro.J Immunol,1994,152(4):1888-1897.
5 Lau W,Devery JM,Geezy CL.A chemotactic S100 peptide enhances scavenger receptor and Mac-1 expression and cholesteryl ester accumulation in murine peritoneal macrophages in vivo.J Clin Invest,1995,95(5):1957-1965.
6 McCormick MM,Rahimi F,Bobryshev YV,et al.S100A8 and S100A9 in human arterial wall.Biol Chem,2005,280 (50):41521-41529.
7 Ghavami S,Kerkhoff C,Los M.et al.Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines:the role of ROS and the effect of metal ions.J Leukocyte Biol,2004,76(1):169-175.
8 Tirkos S,Newbigging S,Nguyen V,et al.Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator.Respir Res,2006,7(1):51.
9 Zhang J,Zhi HY,Luo AP,et al.Expression patterns of esophageal cancer deregulated genes in C57BL/6J mouse embryogenesis.World Gastroenterol,2004,10(8):1088-1092.
10 Stassen T,Port M,Nuyken I,et al.Radiation-induced gene expression in MCF-7 cells.Int J Radiat Biol,2003,79(5):319-331.

相似文献/References:

[1]杨天-,张士猛,秦夏,等.转录反式激活因子对DNA-PKcs启动子的调控作用[J].国际放射医学核医学杂志,2012,36(1):30.[doi:10.3760/cma.j.issn.1673-4114.2012.01.008]
 YANG Tian-yi,ZHANG Shi-meng,QIN xia,et al.The regulation of transactivator of transcription on the activity of DNA-PKcs promoter[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):30.[doi:10.3760/cma.j.issn.1673-4114.2012.01.008]
[2]李继涛,何明远,袁德晓,等.p53调控的能量代谢对辐射效应的影响[J].国际放射医学核医学杂志,2012,36(6):380.[doi:10.3760/cma.j.issn.1673-4114.2012.06.014]
 LI Ji-tao,HE Ming-yuan,YUAN De-xiao,et al.Influence of p53-regulated energy metabolism in radiation effects[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):380.[doi:10.3760/cma.j.issn.1673-4114.2012.06.014]
[3]张晓英,廖端芳.氡及其子体辐射诱发的非癌变效应[J].国际放射医学核医学杂志,2009,33(1):47.[doi:10.3760/cma.j.issn.1673-4114.2009.01.047]
 ZHANG Xiao-ying,LIAO Duan-fang.Radon and its products radiation-induced non-cancerous effect[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(3):47.[doi:10.3760/cma.j.issn.1673-4114.2009.01.047]
[4]周冲,王利利,周菊英.微小RNAs在分子放射生物学中的研究进展[J].国际放射医学核医学杂志,2009,33(2):109.[doi:10.3760/cma.j.issn.1673-4114.2009.02.014]
 ZHOU Chong,WANG Li-li,ZHOU Ju-ying.Progress of microRNAs in molecular radiobiology[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(3):109.[doi:10.3760/cma.j.issn.1673-4114.2009.02.014]
[5]游洋,郭海卓,金顺子.微小RNA在电离辐射和肿瘤中的作用[J].国际放射医学核医学杂志,2009,33(4):243.[doi:10.3760/cma.j.issn.1673-4114.2009.04.016]
 YOU Yang,GUO Hai-zhuo,JING Shun-zi.The role of microRNA in tumor and ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(3):243.[doi:10.3760/cma.j.issn.1673-4114.2009.04.016]
[6]袁德晓,潘燕,沈波,等.辐射诱导的适应性效应及其分子机制[J].国际放射医学核医学杂志,2007,31(5):296.
 YUAN De-xiao,PAN Yan,SHEN Bo,et al.Radioadaptive response and its molecular mechanism[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):296.
[7]肖瑶,韩玲.电离辐射诱导旁效应的研究现状[J].国际放射医学核医学杂志,2007,31(5):303.
 XIAO Yao,HAN Ling.Recent study of ionizing radiation-induced bystander effects[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):303.
[8]王利利,涂彧,周菊英,等.硫酸镁对大鼠急性放射性脑损伤后脂质过氧化的抑制作用[J].国际放射医学核医学杂志,2007,31(1):37.
 WANG Li-li,TU Yu,ZHOU Ju-ying,et al.Inhibitory effect of magnesium sulfate on reaction of lipid hyperoxidation after radiation-induced acute brain injuries[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):37.
[9]杨剑,韩玲.脆性组氨酸三联体与细胞信号转导研究进展[J].国际放射医学核医学杂志,2007,31(3):173.
 YANG Jian,HAN Ling.Progress on fragile histidine triad and cell signal transduction[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):173.
[10]左雅慧,童建.电离辐射的非靶效应和延迟效应[J].国际放射医学核医学杂志,2007,31(3):176.
 ZUO Ya-hui,TONG Jian.Non-targeted and delayed effects of exposure to ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):176.
[11]林向飞,骆丹.MDM2基因与肿瘤放射生物效应[J].国际放射医学核医学杂志,2007,31(2):118.
 LIN Xiangfei,LUO Dan.MDM2 gene and radiobiological effect in tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):118.

备注/Memo

备注/Memo:
收稿日期:2007-03-16。
基金项目:国家自然科学基金资助项目(30400119)
通讯作者:陈肖华,E-mail:Chenxh@nic.hmi.ac.cn
更新日期/Last Update: 1900-01-01