[1]陈素芸.放射性核素标记RGD多肽在整合素受体显像中的应用[J].国际放射医学核医学杂志,2007,31(3):129-132.
 CHEN Su-yun.Application of radiolabeled RGD peptides in imaging of integrin receptor[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):129-132.
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放射性核素标记RGD多肽在整合素受体显像中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第3期
页码:
129-132
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application of radiolabeled RGD peptides in imaging of integrin receptor
作者:
陈素芸
200025 上海, 上海交通大学瑞金医院核医学科
Author(s):
CHEN Su-yun
Department of Nuclear Medicine, Shanghai Ruijin Hospital Affiliated Shanghai Jiaotong University, Shanghai 200025, China
关键词:
受体玻连蛋白肽类放射性核素显像精氨酸-甘氨酸-天冬氨酸
Keywords:
ReceptorvitronectinPeptidesRadionuclide imagingArginine-glycine-aspartic acid
分类号:
R817.4
摘要:
整合素受体αvβ3在新生血管及多种恶性肿瘤细胞表面有高水平的表达,在肿瘤的生长、局部浸润和转移中,特别是肿瘤诱导的血管生成中发挥重要作用。由于放射性核素标记的精氨酸-甘氨酸-天冬氨酸(RGD)多肽能够与受体特异性地识别结合,因此目前被逐渐应用于肿瘤整合素表达水平的受体显像中。
Abstract:
Integrin αvβ3 is highly expressed on activated endothelial cells during angiogenesis and sollid tumor cells. It has been shown to play an essential role in the regulation of tumor growth, local invasiveness, metastatic potential, especially in angiogenesis. Radiolabeld peptides including the tripeptide sequence arginine-glycine-aspartic acid (single-letter code RGD), which can bind to the αvβ3 integrin with high affinity and selectivity, have been developed for determination of αvβ3 integrin expression.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2006-11-18。
更新日期/Last Update: 1900-01-01