[1]冯春玲.放射免疫治疗中载体的研究进展[J].国际放射医学核医学杂志,2007,31(2):77-79.
　FENG Chun-ling.Research advances in carrier of radioimmunotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):77-79.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
77-79
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Research advances in carrier of radioimmunotherapy
作者:
冯春玲
300384 天津, 中国医学科学院中国协和医科大学血液学研究所血液病医院免疫室(硕士研究生)
Author(s):
FENG Chun-ling
Immunology Department, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300384, China
关键词:
放射免疫疗法; 药物载体; 肿瘤
Keywords:
Radioimmunotherapy; Drug carriers; Tumor
分类号:
R914.2
摘要:
放射免疫治疗是应用肿瘤细胞表面表达的特异性分子的单克隆抗体进行核素靶向治疗的一种新方法。通过改进放射性核素的载体,放射免疫治疗的技术不断发展、成熟,其应用范围不断扩展,在未来的疾病定位诊断及治疗中具有很高的应用价值。
Abstract:
Radioimmunotherapy is a new method using nuclid targeting therapy, which utilizing monoclonal antibody labeled nuclid bindes to molecule expressing on carcinoma cell specificitilly. With improving in carrier of nuclid, radioimmunotherapy is more and more consummate, it will have higher value in use in diagnosis and therapy of diseases.

参考文献/References:

1 Cheson BD. Radioimmunotheraphy of non-Hodgkin lymphomas.Blood, 2003, 101(2):391-398.
2 DeNardo GL. Treatment of non-Hodgkin’s lymphoma (NHL) with radiolabeled antibodies (mAbs). Semin Nucl Med, 2005, 35(3):202-211.
3 Kaminski MS, Tuck M, Estes J, et al. 131Ⅰ-tositumomab therapy asinitial treatment for follicular lymphoma. N Engl J Med, 2005,352(5):441-449.
4 Dadachova E, Bryan RA, Apostolidis C, et al. Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection. Infect Dis, 2006, 193(10):1427-1436.
5 Buchsbaum DJ. Imaging and therapy of tumors induced to express somatostatin receptor by gene transfer using radiolabeled peptides and single chain antibody constructs. Semin Nucl Med, 2004, 34(1):32-46.
6 Garambois V, Glaussel F, Foulquier E, et al. Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA)Gold 4 epitope and designed for radioimmunotherapy(RIT) of colorectalcancers. BMC Cancer, 2004, 75(4):1471-1482.
7 Chen ZN, Mi L, Xu J, et al. Targeting radioimmunotherapy of hepat-ocell carcinoma with iodine (131Ⅰ) metuximab injection:clinical phase Ⅰ/Ⅱ trials. Int J Radiat Oncol Biol Phys, 2006, 65(2):435-444.
8 Garkavij M, Samarzija M, Ewers SB, et al. Concurrent radiotherapy and tumor targeting with 131Ⅰn-HMFG1-F(ab’)2 in patients with MUC1-positive non-small cell lung cancer. Anticancer Res, 2005, 25(6C):4663-4667.
9 Li G, Wang Y, Huang K, et al. The experimental study on the radioimmunotherapy of the nasopharyngeal carcinoma overexpressing HER2/neu in nude mice model with intratumoral injection of 188Re-herceptin. Nucl Med Biol, 2005, 32(1):59-65.
10 Morandeau L, Benoist E, Loussouarn A, et al. Synthesis of new bivalent peptides for applications in the affinity enhancement system. Bioconjug Chem, 2005, 16(1):184-193.
11 Boerman OC, Oyen WJG, Corstens FHM. Between the scylla and charybdis of peptide radionuclide therapy:hitting the tumor and saving the kidney. Eur J Nucl Med, 2001, 28(10):1552-1554.
12 Bodei L, Hauekiewicz-Junak D, Grana C, et aL Receptor radionuclide theraphy with Y-DOTATOC in patients with medullary thyroid carcinomas. Cancer Biother Radiophasm, 2004, 19(1):65-71.
13 Schmitt A, Bernhardt P, Nilsson O, et al. Radiation therapy of small cell lung cancer with 117Lu-DOTA-Tyr3-octreotate in an animal model. J Nucl Med, 2004, 45(9):1542-1548.

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　YU Xiao-ming,FAN Fei-yue.Recent developments in radioimmunotherapy of tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):80.

备注/Memo

备注/Memo:
收稿日期:2006-11-18。
更新日期/Last Update: 1900-01-01