[1]姜炜,郭阳,徐玲,等.立体定向放射治疗胰腺癌[J].国际放射医学核医学杂志,2007,31(1):55-57.
　JIANG Wei,GUO Yang,XU Ling,et al.Stereotactic radiotherapy for pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):55-57.
点击复制

立体定向放射治疗胰腺癌(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
55-57
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Stereotactic radiotherapy for pancreatic cancer
作者:
姜炜;  郭阳;  徐玲;  赵卫生
300060 天津, 天津市环湖医院放疗科
Author(s):
JIANG Wei;  GUO Yang;  XU Ling;  ZHAO Wei-sheng
Department of Radiotherapy, Tianjin Huanhu Hospital, Tianjin 300060, China
关键词:
胰腺肿瘤; 立体定向放射治疗; 预后
Keywords:
Pancreatic neoplasms; Stereotactic radiotherapy; Prognosis
分类号:
R730.55
摘要:
目的 对立体定向放射治疗胰腺癌的临床意义进行评价。方法 对16例胰腺癌患者行立体定向放射治疗,病变体积26.5~116.5cm3,肿瘤边缘单次剂量为3~5Gy,治疗10~20次,每日1次,每周治疗5次,治疗后临床和影像手段随访。结果 治疗有效率(完全缓解+部分缓解)为81.2%,合并疼痛患者均有不同程度缓解,6/7患者黄疸消除,生存质量明显改善,中位生存期11个月,死亡原因多为远处转移;治疗副作用根据RTOG标准评价,68.7%患者有轻度早期反应,1例重度晚期反应。结论 立体定向放射治疗胰腺癌是有效的局部控制手段,可明显的缓解症状,改善患者生存质量,并且治疗的并发症可以被临床接受,但肿瘤的远处转移是影响患者生存的主要问题。
Abstract:
Objective To evaluate the therapeutic effects of stereotactic radiotherapy (SRT) on pancreatic cancer. Methods Sixteen patients were treated with SRT, tumor volume 26.5~116.5cm3, single tumor dosage ranged from 3Gy to 5Gy in 10 to 20 fractions, five fractions per week. Patients were followed clinically and image. Results The overall response rate (CR+PR) was 81.2%; the life quality has been improved in evidence. The median survival time was 11 months; the most reason of death was metastasis:The evaluation for acute and late complications related to the treatment was base on RTOG standard, 68.7% patients developed acute complications, and one patient had developed grievously later responses. Conclusion Stereotactic radiotherapy can be used effectively to local control in patients with pancreas cancer, improves life quality, and complications related to the treatment can be accepted by clinically, but tumor metastasis is significantly related with the survival time of patients, combined chemotherapy may be improve survival rate of the patients.

参考文献/References:

1 Milano MT, Chmura SJ, Garofalo MC, et al. Intensity-modulatedrad iotherapy in treatment of pancreatic and bile duct malignancies:toxicity and clinical outcome. Int J Radiat Oncol Biol Phys, 2004,59(2):445-453.
2 Willett CG, Safran H, Abrams RA, et al. Clinical research in pancreatic cancer:the radiation therapy oncology group trials. Int J Radiat Oncol Biol Phys, 2003, 56(4 Suppl):31-37.
3 Brenner DJ, Hall EJ. Stereotactic radiotherapy of intracranial tumor:An ideal candidate for accelerated treatment. Int J Radiat Oncol Biol Phys, 1994, 28(3):1039-1041.
4 Tokuye K, Sumi M, Kagami Y, et al. Small-field radiotherapy in combination with concomitant chemotherapy for locally advanced pancreatic carcinoma. Radiother Oncol, 2003, 67(2):327-330.
5 Martenson JA, Vigliotti AP, Pitot HC, et al. A phase I study of radiation therapy and twice-weekly gemcitabine and cisplatin in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys, 2003, 55(4):1305-1310.
6 吴荣,贾明轩,郭启勇.三维适形放射治疗对局部中晚期胰腺癌的临床意义.中国医科大学学报,2004,33(1):142-146.
7 van Geenen RC, Keyzer-Dekker CM, van Tienhoven G, et al. Pain management of patients with unresectable peripancreatic carcinoma. World J Surg, 2002, 26(6):715-720.

相似文献/References:

[1]徐蓉生,梅艳,赵力威,等.B超引导下术中125I粒子植入治疗晚期胰腺癌的疗效评价[J].国际放射医学核医学杂志,2016,40(6):424.[doi:10.3760/cma.j.issn.1673-4114.2016.06.005]
　Xu Rongsheng,Mei Yan,Zhao Liwei,et al.Evaluation of 125I particle implantation in the treatment of patients with advanced pancreatic neoplasms using B ultrasound-guided surgery[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):424.[doi:10.3760/cma.j.issn.1673-4114.2016.06.005]
[2]李詝,朱朝晖,李方.蛋白激酶小分子抑制剂PET显像研究进展及其在胰腺癌诊断中的应用前景[J].国际放射医学核医学杂志,2015,39(1):45.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
　Li Zhu,Zhu Zhaohui,Li Fang.Advances of small-molecule protein kinase inhibitor-based PET tracers with prospective application in pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):45.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
[3]吴冰,石洪成.18F-FDG PET-CT在胰腺癌诊治中的应用[J].国际放射医学核医学杂志,2011,35(4):234.[doi:10.3760/cma.j.issn.1673-4114.2011.04.010]
　WU Bing,SHI Hong-cheng.18F-FDG PET-CT for the clinical application of pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):234.[doi:10.3760/cma.j.issn.1673-4114.2011.04.010]
[4]邓胜明,张玮,章斌,等.188Re-胰岛素样生长因子1类似物在荷人胰腺癌裸鼠体内分布及其显像研究[J].国际放射医学核医学杂志,2008,32(3):129.
　DENG Sheng-ming,ZHANG Wei,ZHANG Bin,et al.Studies on biodistribution and imaging of 188Re labeled insulin-like growth factor-1 analogue in nude mice bearing human pancreatic carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):129.
[5]尤徐阳,万卫星.放射免疫显像及其在胰腺癌研究中的应用[J].国际放射医学核医学杂志,2008,32(5):264.
　YOU Xu-yang,WAN Wei-xing.Radioimmunoimaging progress and its value of pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):264.
[6]郭阳,姜炜,张文学.立体定向放射治疗脑转移瘤疗效分析[J].国际放射医学核医学杂志,2007,31(2):122.
　GUO Yang,JIANG Wei,ZHANG Wen-xue.Analysis of stereotatic radiotherapy for brain metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):122.
[7]张文学,姜炜,吕仲虹,等.常规放疗结合后程立体定向放射治疗老年非小细胞肺癌患者的预后分析[J].国际放射医学核医学杂志,2007,31(2):125.
　ZHANG Wen-xue,JIANG Wei,LV Zhong-hong,et al.Prognostics analysis of common radiotherapy combined stereotactic radiotherapy for non-small cell lung cancer of old patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):125.
[8]刘军叶,郭鹞,郭国祯.乏氧靶向性自杀基因治疗系统增强胰腺癌放疗效果的实验研究[J].国际放射医学核医学杂志,2006,30(3):168.
　LIU Jun-ye,GUO Yao,GUO Guo-zhen.Hypoxia-targeted suicidal gene therapy system enhances antitumor effects of radiotherapy on pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):168.
[9]王济东,王俊杰.胰腺癌组织间近距离放射治疗的研究进展[J].国际放射医学核医学杂志,2006,30(3):182.
　WANG Ji-dong,WANG Jun-jie.Evolution of interstitial brachytherapy for pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):182.
[10]白静,王俊杰.125I粒子组织间植入治疗局部晚期胰腺癌进展[J].国际放射医学核医学杂志,2006,30(2):127.
　BAI Jing,WANG Jun-jie.Advances in the therapy of pancreatic carcinoma with 125I seeds[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):127.

备注/Memo

备注/Memo:
收稿日期:2006-08-29。
通讯作者:姜讳,E-mail:sun2k@263.net
更新日期/Last Update: 1900-01-01