[1]李詝,朱朝晖,李方.蛋白激酶小分子抑制剂PET显像研究进展及其在胰腺癌诊断中的应用前景[J].国际放射医学核医学杂志,2015,39(1):45-49.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
　Li Zhu,Zhu Zhaohui,Li Fang.Advances of small-molecule protein kinase inhibitor-based PET tracers with prospective application in pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):45-49.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
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蛋白激酶小分子抑制剂PET显像研究进展及其在胰腺癌诊断中的应用前景(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第1期
页码:
45-49
栏目:
出版日期:
2015-01-25

文章信息/Info

Title:
Advances of small-molecule protein kinase inhibitor-based PET tracers with prospective application in pancreatic cancer
作者:
李詝;  朱朝晖;  李方
中国医学科学院北京协和医学院北京协和医院核医学科, 北京, 100730
Author(s):
Li Zhu;  Zhu Zhaohui;  Li Fang
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
关键词:
胰腺肿瘤; 蛋白激酶; 小分子抑制剂; 正电子发射断层显像术; 示踪剂
Keywords:
Pancreatic neoplasms; Protein kinase; Small-molecule inhibitor; Positron-emission tomography; Tracer
DOI:
10.3760/cma.j.issn.1673-4114.2015.01.010
摘要:
胰腺癌为消化道较常见的恶性肿瘤。针对胰腺癌特异性诊断探针和靶向治疗的药物研究包括抗体、亲和体、多肽以及小分子化合物抑制剂,其中针对蛋白激酶的小分子抑制剂的研究备受关注。笔者综述了这一方向的PET示踪剂的研究进展,其中H-89作为异喹啉磺酰基类小分子化合物,可能是最好的胰腺癌蛋白激酶小分子抑制剂之一,用正电子核素标记后,可能成为较有潜力的胰腺癌PET示踪剂。
Abstract:
Pancreatic cancer is one of the most common malignancies of digestive tract. The targeted therapeutic drugs and specific diagnostic probes for pancreatic cancer include antibodies, affinity ligands, polypeptides, and small-molecule protein kinase inhibitors. The research on small-molecule protein kinase inhibitors is a hot topic of both preclinical research and clinical application in recent years.The advances in this area were briefly reviewed in this article. Data indicated that H-89, a kind of isoquinoline sulfonamide small molecule, might be one of the best small-molecule protein kinase inhibitors to treat pancreatic cancer, and if labeled with positron emitter, it might become a potential PET tracer for pancreatic cancer.

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备注/Memo

备注/Memo:
收稿日期:2014-12-19。
基金项目:公益性行业科研专项(201402001);国家自然科学基金(81171369)
通讯作者:李方,Email:lifang@pumch.cn
更新日期/Last Update: 1900-01-01