[1]胡莹莹,蒋宁一.131Ⅰ治疗分化型甲状腺癌的现状和进展[J].国际放射医学核医学杂志,2006,30(6):343-346.
 HU Ying-ying,JIANG Ning-yi.Radiodione treatment of differentiated thyroid cancer: current status and future prospects[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(6):343-346.
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131Ⅰ治疗分化型甲状腺癌的现状和进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第6期
页码:
343-346
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Radiodione treatment of differentiated thyroid cancer: current status and future prospects
作者:
胡莹莹 蒋宁一
510120 广州, 中山大学附属第二医院核医学科
Author(s):
HU Ying-ying JIANG Ning-yi
Nuclear Medicine Department, The Second Affiliated Hospital of Zhaongshan University, Guangzhou 510120, China
关键词:
碘放射性同位素甲状腺肿瘤综合疗法
Keywords:
Iodine radioisotopesThyroid neoplasmsCombined modality therapy
分类号:
R817.5
摘要:
分化型甲状腺癌(DTC)包括乳头状癌和滤泡状癌,占甲状腺恶性肿瘤的90%以上。DTC恶性程度不高,其肿瘤细胞保留了甲状腺细胞的摄碘功能,目前常用"手术+131Ⅰ治疗+甲状腺素抑制"的综合疗法治疗DTC,提高了DTC患者的生存率,但在DTC病变发展过程中,肿瘤细胞有失分化的趋势,其摄取碘的功能降低甚至消失。目前针对DTC治疗的研究趋势主要包括基因重组人促甲状腺激素的临床应用,维甲酸的诱导再分化及钠燃运体基因的研究。
Abstract:
More than 90% of primary thyroid cancers are differentiated papillery or follicular types. The popular treatment of differentiated thyroid carcinoma(DTC) consist of surgery, radioiodine ablation and thyroid stimulating hormone suppressive therapy, which increase clinical benefit rate. During tumor progression, cellular de-differentiation occurs in up to 30% of cases and usually result in the loss of iodine uptake. The current resercbes aiming to improve treatment effect of DTC including clinical application of rhTSH, retinoic acid inducement to re-differentiation and gene therapy on sodium-iodide symporter.

参考文献/References:

1 刑家骝.131碘治疗甲状腺疾病.北京:人民卫生出版社,2002.272-307.
2 Patel A, Jhiang S, Dogra S, et al. Differentiated thyroid carcinoma that express sediun-iodine symporter have a lower risk of recurrence for children and adolescents. Pediat Res, 2002, 52(5):737-744.
3 Kalinyak JE, McDougall IR Whole-body scanning with radionuclides of iodine and the controversy of thyroid stunninng. Nucl Med Commun, 2004, 25(9):883-889.
4 Chen CH, Chen JF, Yang BY, et al. Bone mineral density in woman receiving thyroxine suppressive therapy for differentiated thyroid carcinoma. J Formos Med Assoc, 2004, 103(6):442-447.
5 Lazar V, Bidart JM, Caillou B, et al. Expression of the Na+/I- symporter gene in human thyroid tumors:a comparasin study with other thyroid specific genes. J Clin Endocrinol Metab, 1999, 84(9):3228-3234.
6 Mazzaferri EL, Bobbins B J, Spencer CA, et al. A consensus report of the role of serun thyglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab, 2003, 88(4):1433-1441.
7 田蓉,潘明志,匡安仁.Tg升高131I显像阴性的甲状腺癌患者131I疗效评价.中华核医学杂志,2003,23(1):27-29.
8 Saito T, Endo J, Kawaguchi A, et al. Increased expression of the Sodium/iodine symporter in papillary thyroid carcinomas. J Clin Invest, 1998, 101(7):1296-1300.
9 Pacini F, Capezzone M, Elisei R, et al. Diagnostic 131-iedine whole body scan may be avoided in thyroid cancer patients who have undetectable stimulated senun Tg levels after initial treatment. J Clin Endocrinol Metab, 2002, 87(4):1499-1501.
10 Simon D, Koehrle J, Reiners C, et al. Redifferentiation therapy with retinoids:therapeutic option for advanced follicular and advanced follicular and papillary thyroid carcinoma. World J Surg,1998, 22(6):569-574.
11 Kohlfuerst S, Igerc L Lind P. Recombinant human thyrotropin is helpful in the follow-up and 131Ⅰ therapy of patients with thyroid cancer, a report of the results and benefits using recombinant human thyrotropin in clinical routine. Thyroid, 2005, 15(4):371-376.
12 David A, Blotta A, Rossi R, et al. Clinical value of different responses of serum thyroglobulin to recombinant human thyrotrepin in the follow-up of patients with differentiated thyroid carcinoma. Thyroid, 2005, 15(3):267-273.
13 Luster M, Lippi F, Jarzab B, et al. rhTSH-aided radioiodine ablation and treatment of differentiated thyroid carcinoma:a comprehensive review. Endocr Relat Cancer, 2005, 12(1):49-64.
14 Loffler M, Weckesser M, Franzius C, et al. lodine excretion during stimulation with rhTSH in differentiated thyroid carcinoma. Nuldearmedizin, 2003, 42(6):240-243.
15 Menzel C, Kranert WT, Dobert N, et al. rhTSH stimulation before radioiodine therapy in thyroid cancer reduces the effective half-life (131)Ⅰ. J Nucl Meal, 2003, 44(7):1065-1068.
16 Coelho SM, Vaisman M, Carvalho DP. Tumour redifferentiation effect of retinoic acid:a novel therapeutic approach for advanced thyroid cancer. Curt Phann Des, 2005, 11(19):2525-2531.
17 Cho JY. A transporter gene (sodium iodine smporter) for dual purposes in gene therapy:imaging and therapy. Curr Gene Ther,2002, 2(4):393-402.
18 Venkatarman GM, Yatin M, Marcinek R, et al. Restoration of iodine uptake in differentiated thyroid carcinoma:relalionship to human Na+/I- symporter gene methylatlon status. J Clin Endocrinol Metab, 1999, 84(7):2449-2457.
19 Zarnegar R, Bnmaud L, Kanauchi H, et al. Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using trichostatin A (TSA), a histone deacetylase inhibitor.Surgery, 2002, 132(6):984-990.
20 Dohan O, Baloch Z, Banrevi Z, et al. Rapid communication:predominant intracellular overexpression of the Na+/I- symporter (NIS) in a large sampling of thyroid cancer cades. J Clin Endocrinol Metab, 2001, 86(6):2697-2700.

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备注/Memo

备注/Memo:
收稿日期:2005-12-19。
通讯作者:蒋宁一,E-mail:ningyij@163.net
更新日期/Last Update: 1900-01-01