[1]王济东,王俊杰.胰腺癌组织间近距离放射治疗的研究进展[J].国际放射医学核医学杂志,2006,30(3):182-184.
 WANG Ji-dong,WANG Jun-jie.Evolution of interstitial brachytherapy for pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):182-184.
点击复制

胰腺癌组织间近距离放射治疗的研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第3期
页码:
182-184
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Evolution of interstitial brachytherapy for pancreatic cancer
作者:
王济东 王俊杰
100083 北京, 北京大学第三医院肿瘤治疗中心
Author(s):
WANG Ji-dong WANG Jun-jie
Department of Oncology, The Third Hospital of Beijing University, Beijing 100083, China
关键词:
胰腺肿瘤近距离放射疗法放射性粒子
Keywords:
Pancreatic neoplasmsBrachytherapyRadioactive seeds
分类号:
R817.5
摘要:
胰腺癌仍是肿瘤学目前难以攻克和富有挑战性的难题,放射性粒子由于其物理及生物学的特点,治疗胰腺癌具有独特的优势。放射性粒子离体照射模型的设计和建立,为研究粒子辐射生物效应提供了有效和重要的方法,并已广泛用于放射生物学和剂量学的研究。临床研究显示,胰腺癌组织间近距离放射治疗能够提高局部控制率、减轻疼痛、改善患者生活质量和提高生存率,是治疗胰腺癌的一种重要方法。
Abstract:
Cancer of the pancreas remains a formidable challenge in oncology presently. It has unique advantages to treat pancreatic cancer by radioactive seeds because it has many physical and biological characteristics. The seed irradiator designed and built is very efficient and effective and has already been used extensively in radiobiological experiments and the accuracy of dosimetry. From reported clinical results, interstitial brachytherapy for pancreatic cancer can control tumor, relieve pain, improve quality of life and survival. It is an important modality in the treatment of pancreatic cancer.

参考文献/References:

1 Willett CG, Clark JW. Update on combined-modality treatment options for pancreatic cancer. Oncology, 2003, 17(12):29-36.
2 Earle CC, Agboola O, Maroun J, et al. The treatment of locally advanced pancreatic cancer:, a practice guideline. Can J Gastroenterol,2003, 17(3):161-167.
3 Ling CC, Li WX, Anderson LL The relative biological effectiveness of I-125 and Pb-103. Int J Radiat Oncol Biol Phys, 1995, 32(2):373-378.
4 Aird EG, Folkard M, Mayes CR, et al. A purpose-buih iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro. Br J Radiol, 2001, 74(877):56-61.
5 Mastsui Y, Asano T, Kenmochi T, et al. Effects of carbon-ion beams on human pancreatic cancer cell line that differ in genetic status. Am J Clin Oncol, 2004, 27(1):24-28.
6 Ghaneh P, Greenhalf W, Humphreys M, et al. Adenovirus-mediated transfer of p53 and p16(INK4a)resuhs in pancreatic cancer regression in vitro and vivo. Gene Ther, 2001, 8(3):199-208.
7 Collis SJ, Schwaninger JM, Ntambi AJ, et al. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem, 2004, 279(48):49624-49632.
8 Nath R, Bongiorni P, Chen Z, et al. Development of a rat solid tumor model for continuous low-dose-rate irradiation studies using 125I and 103Pd sources. Brachytherapy, 2004, 3(3):159-172.
9 王俊杰,修典荣,冉维强.放射性粒子组织间近距离治疗肿瘤.第2版,北京:北京大学出版社,2004.177-192.
10 Bodner WR, Hilaris BS, Mastoras DA. Radiation therapy in pancreatic cancer:current practice and future trends. J Clin Gastroenterol, 2000, 30(3):230-233.
11 Joyce F, Burcharth F, Holm HH, et al. Ultrasonically guided percutaneous implantation of iodine-125 seeds in pancreatic carcinoma. Int J Radiat Oncol Biol Phys, 1990, 19(4):1049-1052.

相似文献/References:

[1]田琦,张丽花,蒋宁一.甲状腺癌131I治疗后合并骨髓增生异常综合征一例[J].国际放射医学核医学杂志,2016,40(3):235.[doi:10.3760/cma.j.issn.1673-4114.2016.03.014]
[2]霍小东,王慧星,阎卫亮,等.血管内皮抑制素对125I近距离照射裸鼠肺癌移植瘤的增敏效应研究[J].国际放射医学核医学杂志,2016,40(5):357.[doi:10.3760/cma.j.issn.1673-4114.2016.05.006]
 Huo Xiaodong,Wang Huixing,Yan Weiliang,et al.Sensitization effect of endostatin for 125I brachytherapy on transplanted tumor in nude mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):357.[doi:10.3760/cma.j.issn.1673-4114.2016.05.006]
[3]张丽花,蒋宁一.131I治疗Graves甲亢合并肝功能损害或血细胞减少的优势与风险[J].国际放射医学核医学杂志,2015,39(6):483.[doi:10.3760/cma.j.issn.1673-4114.2015.06.010]
 Zhang Lihua,Jiang Ningyi.The advantage and risk of 131I treatment in hyperthyroidism combined with liver injury or blood cell reduction[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):483.[doi:10.3760/cma.j.issn.1673-4114.2015.06.010]
[4]杨宝军.131I治疗甲亢合并特发性血小板减少性紫癜一例[J].国际放射医学核医学杂志,2015,39(6):511.[doi:10.3760/cma.j.issn.1673-4114.2015.06.017]
[5]李詝,朱朝晖,李方.蛋白激酶小分子抑制剂PET显像研究进展及其在胰腺癌诊断中的应用前景[J].国际放射医学核医学杂志,2015,39(1):45.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
 Li Zhu,Zhu Zhaohui,Li Fang.Advances of small-molecule protein kinase inhibitor-based PET tracers with prospective application in pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):45.[doi:10.3760/cma.j.issn.1673-4114.2015.01.010]
[6]赵腾,梁军,林岩松.131I治疗前刺激性Tg在分化型甲状腺癌风险评估及治疗决策中的意义[J].国际放射医学核医学杂志,2015,39(1):61.[doi:10.3760/cma.j.issn.1673-4114.2015.01.013]
 Zhao Teng,Liang Jun,Lin Yansong.The role of preablative stimulated thyroglobulin in guiding risk estimation and therapeutic decisions of differentiated thyroid carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):61.[doi:10.3760/cma.j.issn.1673-4114.2015.01.013]
[7]侯朝华,霍彬,宋杨.组织间近距离放射性粒子植入治疗肿瘤的进展[J].国际放射医学核医学杂志,2015,39(4):348.[doi:10.3760/cma.j.issn.1673-4114.2015.04.016]
 Hou Zhaohua,HuoBin,SongYang.Organizational close radioactive seed implantation therapy in treating tumor progression[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):348.[doi:10.3760/cma.j.issn.1673-4114.2015.04.016]
[8]俞秀华,黄炜坤,林玉梅.131I治疗Graves病合并肝损害的临床观察[J].国际放射医学核医学杂志,2014,38(2):90.[doi:10.3760/cma.j.issn.1673-4114.2014.02.005]
 Yu Xiuhua,Huang Weikun,Lin Yumei.Clinical observation of 131I therapy in Graves disease patients with hepatic dysfunction[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):90.[doi:10.3760/cma.j.issn.1673-4114.2014.02.005]
[9]张俊涛.晚期肺癌125I粒子植入治疗近期疗效观察[J].国际放射医学核医学杂志,2014,38(2):94.[doi:10.3760/cma.j.issn.1673-4114.2014.02.006]
 Zhang Juntao.Short-term efficacy of 125I seeds implantation in the treatment of advanced lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):94.[doi:10.3760/cma.j.issn.1673-4114.2014.02.006]
[10]成钊汀,谭建.分化型甲状腺癌术后患者131I治疗的辐射剂量与防护[J].国际放射医学核医学杂志,2014,38(2):110.[doi:10.3760/cma.j.issn.1673-4114.2014.02.010]
 Cheng Zhaoting,Tan Jian.Radiation dose and protection of differentiated thyroid carcinoma postoperative patients with 131I treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):110.[doi:10.3760/cma.j.issn.1673-4114.2014.02.010]
[11]徐蓉生,梅艳,赵力威,等.B超引导下术中125I粒子植入治疗晚期胰腺癌的疗效评价[J].国际放射医学核医学杂志,2016,40(6):424.[doi:10.3760/cma.j.issn.1673-4114.2016.06.005]
 Xu Rongsheng,Mei Yan,Zhao Liwei,et al.Evaluation of 125I particle implantation in the treatment of patients with advanced pancreatic neoplasms using B ultrasound-guided surgery[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):424.[doi:10.3760/cma.j.issn.1673-4114.2016.06.005]
[12]白静,王俊杰.125I粒子组织间植入治疗局部晚期胰腺癌进展[J].国际放射医学核医学杂志,2006,30(2):127.
 BAI Jing,WANG Jun-jie.Advances in the therapy of pancreatic carcinoma with 125I seeds[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):127.

备注/Memo

备注/Memo:
收稿日期:2005-11-18。
通讯作者:王俊杰(E-mail:junjiew@263.net)
更新日期/Last Update: 1900-01-01