[1]赵伟,张秀丽.PET报告基因显像研究进展[J].国际放射医学核医学杂志,2005,29(5):238-240,封三.
　ZHAO Wei,ZHANG Xiu-li.The progress of PET based reporter gene imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):238-240,封三.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第5期
页码:
238-240,封三
栏目:
PET-CT的药物研究
出版日期:
1900-01-01

文章信息/Info

Title:
The progress of PET based reporter gene imaging
作者:
赵伟;  张秀丽
250117 济南, 山东省肿瘤研究院PET中心
Author(s):
ZHAO Wei;  ZHANG Xiu-li
PET Center, Shandong Oncology Hospital & Institute, Jinan 250117, China
关键词:
基因治疗; 正电子发射体层扫描; 报告基因
Keywords:
gene therapy; positron emission tomography; reporter genes
分类号:
R817.4
摘要:
近20年的基因研究已经取得了很多研究成果,使基因治疗从实验室走向临床治疗成为可能。然而体内基因表达的监测仍有许多至关重要的问题没有解决,随着技术的发展,利用特定的报告基因和报告探针行PET显像,去推测基因在体内的表达成为可能。通过PET,不但能够正确理解基因治疗的过程,也为基因治疗的发展和用于临床提供了依据。
Abstract:
More than two decades of intense research have allowed gene therapy to move from the laboratory to the clinical setting, where its use for the treatment of human pathologies has been considerably increased in the last years. However, many crucial questions remain to be solved in this challenging field. In vivo imaging with positron emission tomography (PET) by combination of the appropriate PET reporter gene and PET reporter probe could provide invaluable qualitative and quantitative information to answer multiple unsolved questions about gene therapy. PET imaging could be used to define parameters not available by other techniques that are of substantial interest not only for the proper understanding of the gene therapy process, but also for its future development and clinical application in humans.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-06-15。
更新日期/Last Update: 1900-01-01