[1]王佳琼,王自正.基因转移技术与基因靶向性核素治疗[J].国际放射医学核医学杂志,2004,28(4):145-149.
　WANG Jia-qiong,WANG Zi-zheng.Gene transfer technology and genetic radioisotope targeting therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(4):145-149.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第4期
页码:
145-149
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Gene transfer technology and genetic radioisotope targeting therapy
作者:
王佳琼;  王自正
210006 南京, 南京医科大学附属南京市第一医院临床核医学中心
Author(s):
WANG Jia-qiong;  WANG Zi-zheng
Department of Nuclear Medicine, Nanjing First Hospital Affiliated Nanjing Medical University, Nanjing 210006, China
关键词:
基因转移载体; 基因显像; 基因治疗; 基因靶向核素治疗
Keywords:
gene transfer vector; gene imaging; gene therapy; genetic radioisotope targeting therapy
分类号:
R817.5
摘要:
随着在细胞分子水平上对疾病发病机制认识的深入,基因治疗已成为目前医学分子生物学最重要的研究领域之一。基因治疗过程中基因转移技术起着关键作用,携带目的基因的载体有待进一步开发和改进。在基因治疗过程中,需要进行基因监测,基因显像是其最有效的方法。将基因治疗与靶向核素治疗相结合,即"基因靶向核素治疗"为肿瘤基因治疗开辟了一条崭新的途径。
Abstract:
With deeper cognition about mechanisms of disease at the cellular and molecular level, gene therapy has become one of the most important research fields in medical molecular biology at present. Gene transfer technology plays an important role during the course of gene therapy, and further improvement should be made about vectors carrying target gene sequences. Also, gene survey is needed during gene therapy, and gene imaging is the most effective method. The combination of gene therapy and targeted radiotherapy, that is,"Genetic Radioisotope Targeting Therapy", will be a novel approach to tumor gene therapy.

参考文献/References:

1 Heo DS.Progress and limitations in cancer gene therapy[J].Genet Med,2002,4(6 Suppl):52S-55S.
2 St George JA.Gene therapy progress and prospects:adenoviral vectors[J].Gene Ther,2003,10(14):1135-1141.
3 Springer CJ,Niculescu-Duvazl I.Prodrug activating systems in suicide gene therapy[J].J Clin Inves,2000,105(9):1161-1167.
4 Lundstrom K.Latest development in viral vectors for gene therapy[J].Trends Biotechnol,2003,21(3):117-122.
5 Romano G,Pacilio C,Giordano A.Gene transfer technology in the rapy:current applications and future goals[J].Stem Cells,1999,17(4):191-202.
6 DONG Wen-ji,ZU Zhen-xiang,LIU De-pei,et al.Development ofgene therapy for hematopoietic stem cell using viral vectors[J].ActaGenetica Sinica,2003,30(4):382-388.
7 Buller RE,Runnebaum IB,Karlan BY,et al.A phase I/II trial ofrAd/p53(SCH58500) gene replacement in recurrent ovarian cancer[J].Cancer Gene Ther,2002,9(7):553-566.
8 Fukuda Y,Yamamura J,Uwano T,et al.Regulated transgene delivery by ganciclovir in the brain without physiological alterations by a live attenuated herpes simplex virus vector[J].Neurosci Res,2003,45(2):233-241
9 Park J,Ries J,Gelse K,et al.Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer:a comparison of adeno viral vectors and liposomes[J].Gene Ther,2003,10(13):1089-1098.
10 Ramesh R,Saeki T,Templeton NS,et al.Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector[J].Mol Ther,2001,3(3):337-350.
11 Kaiser J.Gene therapy.RAC’s advice:proceed with caution[J].Science,2002,298(5601):2113-2115.
12 Kaiser J.Gene therapy.Seeking the cause of induced leukemias in X-SCID trial[J].Science,2003,299(5606):495.
13 Marshall E.Clinical research.Gene therapy a suspect in leukemia-liked disease[J].Science,2002,298(5591):34-35.
14 Check E.Safety panel backs principle of gene therapy trials[J].Nature,2002,420(6916):595.
15 Richard JC,Factor P,Welch LC,et al.Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography[J].Gene Ther,2003,10(25):2074-2080.
16 Umegaki H,Ishiwata K,Ogawa O,et al.Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young,middle-aged,and aged rats:a positron emission tomography study[J].Neuroscience,2003,121(02):479-486.
17 Rogers BE,Chaudhuri TR,Reynolds PN,et al.Non-invasive gamma camera imaging of gene transfer using an adenoviral vectorencodingan epitope-tagged receptor as a reporter[J].Gene Ther,2003,10(2):105-114.
18 Dewanjee MK,Ghafouripour AK,Kapadvanjwala M,et al.Noninva-sive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model[J].J Nucl Med,1994,35(6):1054-1063.
19 Mairs R J,Cunningham SH,Boyd M,et al.Application of gene transfer to targeted radiotherapy[J].Curr Pharm Des,2000,6(14):1419-1432.
20 Buchsbaum DJ.Imaging and therapy of tumors induced to express somatostatin receptor by gene transfer using radiolabeled peptides and single chain antibody constructs[J].Semin Nucl Med,2004,34(1):32-46.
21 Rogers BE,Zinn KR,Buchsbaum DJ.Gene transfer strategies for improving radiolabeled peptide imaging and therapy[J].Q J Nucl Med,2000,44(3):208-223.
22 Rosenfeld ME,Rogers BE,Khazaeli MB,et al.Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo[J].Clin Cancer Res,1997,3(7):1187-1194.
23 Celinski SA,Fisher WE,Amaya F,et al.Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts[J].J Surg Res,2003,115(1):41-47.
24 Boland A,Magnon C,Filetti S,et al.Transposition of the thyroid iodide uptake and organification system in nonthyroid tumor cells by adenoviral vector-mediated gene transfers[J].Thyroid,2002,12(1):19-26.
25 Watanabe N,Sawai H,Endo K,et al.Labeling of phosphorothioate antisense oligonucleotides with yttrium-90[J].Nucl Med Biol,1999,26(2):239-243.

相似文献/References:

[1]穆传杰,周继文.报告基因显像监测基因治疗研究进展[J].国际放射医学核医学杂志,2003,27(1):4.
　MU Chuan-jie,ZHOU Ji-wen.Advances in study of reporter gene imaging for monitoring gene therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):4.
[2]穆传杰.肿瘤基因治疗中的基因显像[J].国际放射医学核医学杂志,1999,23(3):128.

备注/Memo

备注/Memo:
收稿日期:2004-05-19。
更新日期/Last Update: 1900-01-01