[1]王明芳.医用回旋加速器及正电子核素生产[J].国际放射医学核医学杂志,2002,26(5):231-236.
 WANG Ming-fang.Medical cyclotron and positron emitting nuclide[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(5):231-236.
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医用回旋加速器及正电子核素生产(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第5期
页码:
231-236
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Medical cyclotron and positron emitting nuclide
作者:
王明芳
510515 广州, 广州第一军医大学南方医院PET中心
Author(s):
WANG Ming-fang
Nanfang PET center, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
关键词:
回旋加速器正电子核素标记前体
Keywords:
cyclotronpositron -emitting nuclideprecursor
分类号:
R817.4
摘要:
PET(正电子发射体层)显像是利用解剖形态方式对体内各种生物化学过程如代谢和受体功能改变等进行评价和定量观测的核医学技术,PET的发展在一定程度上取决于正电子显像剂的研制与应用。PET所采用的正电子显像剂主要是用由回旋加速器生产的正电子核素-11C、13N、15I、18F等标记。因此,了解并掌握医用回旋加速器的基本组成和工作原理,选择适当的正电子核素及其标记前体,对正电子显像剂的常规生产和研究开发有重要的指导意义。主要介绍了回旋加速器的操作原理、医用回旋加速器的类型和正电子核素及其标记前体的生产。
Abstract:
Positron emission tomography (PET)has been widely used to visualize,localize and quantify the different biochemical processes and parameters such as metabolic processes and receptor densities using anatomical modality.The development of PET technique is to depend on the development and application of positron emitting tracers.The PET radiotracers labelled with positron emitting radionuclides such as 18F,15O,13N and 11C are commonly produced in cyclotron.Therefore,it is very important to master the operational principles and the essential component of the cyclotron,and to select the suitable positron emitting radionuclides and corresponding la belling precursors for the routine production and development of PET imaging agents.This review described the principle of operation of the cyclotron,types of medical cyclotrons,production of radionuclides and labelling precursors.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-03-29。
基金项目:广东省医学科研基金课题(A2001381)
作者简介:王明芳(1963-),男,甘肃天水人,主治医师,讲师,硕士研究生,主要从事正电子放射性药物合成与代谢研究。
更新日期/Last Update: 1900-01-01