[1]吴国清.低剂量福射的细胞遗传适应性反应机理研究现状[J].国际放射医学核医学杂志,2002,26(3):127-130.
　WU Guo-qing.The intrinsic mechanism of cytogenetic adaptive response to low dose radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(3):127-130.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第3期
页码:
127-130
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The intrinsic mechanism of cytogenetic adaptive response to low dose radiation
作者:
吴国清
400016 重庆, 重庆医科大学核医学教研室
Author(s):
WU Guo-qing
Department of nuclear medicine, Chongqing University of Medical Science, Chongqing 400016, China
关键词:
低剂量辐射; 适应性反应; DNA修复; 细胞周期
Keywords:
low dose radiation; adaptive response; DNA repair; cell cycle
分类号:
R811.5
摘要:
很多学者对LDR(低剂量辐射)可以在体内及体外培养的细胞中诱导出适应性反应的机理进行了深入的研究,发现适应性反应的诱导与很多因素有关,这些因素包括LDR诱导的DNA修复系统的激活、LDR诱导的基因和蛋白的作用、抗氧化物酶的作用、细胞信号转导以及与P53蛋白有关的细胞周期阻滞的影响等。
Abstract:
Low dose radiation (LDR) can induce adaptive response in vivo and cultured cells.This phenomenon has been confirmed for more than 10 years. After the discovery, numerous research works on its intrinsic mechanism have been carried out. It was reported that the adaptive response is related to many factors. These factors include the DNA repair system induced by LDR,the function of genes and proteins induced by LDR,the function of antioxidant enzyme,cel-luar signal transduction and cell-cycle delay relation to p53 and so on.

参考文献/References:

[1] Tiku AB,Kale RK. Radiomodification of glyoxalase Ⅰ in the liver and spleen of mice:adaptive response and split-dose effect[J].Molecular and Cellular Biochemistry,2001,(1-2):79-83.
[2] Wolff S. Aspects of the adaptive response to very low doses of radiation and the other agents[J].Mutation Research,1996.135-142.
[3] Tempel K,Schliefer S. Adaptive response of the chicken embryo to low doses of X-irradiation[J].Radiation and Environmental Biophysics,1995,(03):177-183.
[4] Cai L,Cherian MG. Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes:effect of pre-exposure to zinc,and copper salts[J].Mutation Research,1996.233-241.
[5] Chen SL,Cai L,Meng QY. Low-dose whole-body irradiation(LD-WBI) changes protein expression of mouse thymocyte:effect of a LD-WBI-enhanced protein RIP10 on cell proliferation and spontaneous or radiation-induced thymocyte apoptosis[J].Toxicological Sciences,2000,(01):97-106.
[6] Cong XL,Wang XL,Su Q. Protective effects of extracted human-liver RNA,a known interteron inducer,against radiation-induced cytogenetic damage in mice[J].Toxicology Letters,1998,(03):189-198.
[7] Bravard A,Luccioni C,Moustacchi E. Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblast[J].International Journal of Radiation Oncology,Biology,Physics,1999,(05):639-645.
[8] Sasaki MS. On the reation kinetics of the radicadaptive response in culture mouse cells[J].International Journal of Radiation Oncology,Biology,Physics,1995.281-291.
[9] Shimizu T,Kato T Jr,Tachibana A. Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase[J].Experimental Cell Research,1999.424-432.
[10] Little JB,Nagasawa H,Keng PG. Absence of radiation-induced G_1 arrest in two closely related human lymphoblast cell lines that differ in p53 status[J].Journal of Biological Chemistry,1995,(19):11033-11036.
[11] Hendrikse AS,Hunter AJ,Keraan M. Effects of low dose irradiation on TK6 and U937 cells:induction of p53 and its role in cell-cycle delay and the adaptive response[J].International Journal of Radiation Oncology,Biology,Physics,2000,(01):11-21.
[12] Lee SJ,Choi SA,Cho CK. Adaptive response is differently induced depending on the sensitivity to radiation-induced cell death in mouse epidermal cells[J].Cell Biology and Toxicology,2000,(03):175-184.
[13] Ishii K,Watanable M. Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays[J].International Journal of Radiation Oncology,Biology,Physics,1996,(03):291-299.
[14] Park SH,Lee Y,Jeong K. Different induction of adaptive response to ionizing radiation in normal and neoplastic cells[J].Cell Biology and Toxicology,1999,(02):111-119.
[15] Gadhia PK. Possible age-dependent adaptive response to low dose of X-rays in human lymphocytes[J].Mutagenesis,1998,(02):151-152.

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备注/Memo

备注/Memo:
收稿日期:2002-1-30。
作者简介:吴国清(1973-),男,浙江衢州人,硕士研究生,主要从事肿瘤放射治疗研究。
更新日期/Last Update: 1900-01-01