[1]高刚.低剂量辐射诱导适应性反应的分子机制研究现状[J].国际放射医学核医学杂志,2003,27(6):276-278.
　GAO Gang.Molecular mechanism of adaptive response to low dose radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(6):276-278.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第6期
页码:
276-278
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Molecular mechanism of adaptive response to low dose radiation
作者:
高刚
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
GAO Gang
Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
低剂量辐射; 适应性反应; 信号转导; 活性氧物质; DNA修复
Keywords:
low dose radiation; adaptive response; singal transduction pathway; reactive oxygen species; DNA damage repair
分类号:
Q506
摘要:
低剂量辐射(low dose radiation,LDR)可以增强细胞对随后进行的攻击性剂量(challenge dose)照射的抵抗能力,从而降低攻击性照射引起的染色体畸变和DNA损伤。人们把LDR的这种效应称之为"低剂量辐射诱导的适应性反应"。低剂量辐射诱导适应性反应的分子机制主要涉及细胞信号转导、ROS(活性氧物质)的作用和DNA修复兴奋效应等方面。
Abstract:
Adaptive response is a term used to describe the ability of a low, priming dose of ionizing radiation to modify the effects of a subsequent higher, challenge dose. Molecular mechanism of adaptive response to low dose radiation is involved in singal transduction pathway, reactive oxygen species, DNA damage repair.

参考文献/References:

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[9] Ikushima T. Radio-adaptive response:enchancement of repair of radiation induced DNA damage by pre-exposure to low doses of ionizing radiation[C]. Proceeding of International Symposium on Biological Effects of Low Level Exposures to Radiation and Related Agents. Changchun:China,1993.37.
[10] Sorensen KJ, Attix CM, Christian AT, et al. Adaptive response induction and variation in human lymphoblastoid cell line[J]. Mutat Res, 2002, 519:15-24.

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备注/Memo

备注/Memo:
收稿日期:2003-06-19
基金项目:天津市自然科学基金资助项目(023611111)
作者简介:高刚(1976-),男,硕士研究生,主要从事低剂量辐射对肿瘤放疗疗效机制的研究。
更新日期/Last Update: 1900-01-01