[1]游冬青,陈杞.加速器质谱技术在DNA加合物检测中的应用[J].国际放射医学核医学杂志,2002,26(3):124-126.
　YOU Dong-qing,CHEN Qi.Application of accelerator mass spectrometry in studies of DNA adducts[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(3):124-126.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第3期
页码:
124-126
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Application of accelerator mass spectrometry in studies of DNA adducts
作者:
游冬青;  陈杞
200433 上海, 第二军医大学放射医学教研室
Author(s):
YOU Dong-qing;  CHEN Qi
Department of Radiation & Nuclear Medicine of Second Military Medical University, Shanghai 200433, China
关键词:
加速器质谱技术; DNA加合物; 化学致癌
Keywords:
accelerator mass spectrometer; DNA adduct; chemical carcinogens
分类号:
TL817+.4
摘要:
大部分化学致癌物进入体内,或经代谢活化后,可与生物大分子——蛋白质或核酸形成共价相连的加合物,DNA加合物的形成是化学致癌过程中一个早期、可检测到的关键步骡。加速器质谱技术(accelemtor mass spectrometry,AMS)的DNA加合物检测,是目前最灵敏的检测方法,提供了人们研究低剂量效应的直接有力的手段。
Abstract:
Most chemical carcinogens,after intake,or after metabolic activation,can form covalent modifications of DNA(DNA adducts).DNA adducts formation induced by carcinogenic chemicals reflects exposure and is directly related to tumor formation.DNA adduct is a valid indicator of early key stage of carcinogenesis.Accelarator mass spectrometry (AMS) is a relatively new nuclear technique,has been developed for the detection of DNA adduct with great detection sensitivity.This powerful application allows studying molecular effects at the low-dose carcinogen exposure.

参考文献/References:

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[5] Wendy AS,Ramesh CG. Determining efficacy of cancer chemopreventive agents using a cell-free system concomitant with DNA adductions[J].Mutation Research,1999.143-152.
[6] Turteltaub KW,Felton JS,Gledhill BL. Accelerator mass spectrometry in biomedical dosimetry:Relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA[J].Proceedings of the National Academy of Sciences of the United States of America,1990.5288-5292.
[7] Felton JS,Turteltaub KW,Vogel JS. Accelerator mass spectrometry in biomedical science s:Applications in low exposure biomedical and environmental dosimetry[J].Nuclear Instruments and Methods in Physics Research,1990.517-523.
[8] Turteltaub KW,Felton JS,Gledhill BL. Accelerator mass spectrometry in biomedical dosimetry:Relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA[J].Proceedings of the National Academy of Sciences of the United States of America,1990.5288-5292.
[9] Vogel JS. Rapid production of graphite without contamination for biomedical AMS[J].Radiocarbon,1992.344-350.

备注/Memo

备注/Memo:
收稿日期:2002-1-25。
基金项目:国家自然科学基金资助项目(19875077)
作者简介:游冬青(1968-),女,福建福州人,副教授,硕士生导师,主要从事实验核医学与放射生物学研究。;陈杞(1932-),男,河南开封人,教授,博士生导师,主要从事实验核医学和放射毒理学研究。
更新日期/Last Update: 1900-01-01