[1]华逢春.11C-METPET在脑肿瘤中的应用[J].国际放射医学核医学杂志,2002,26(1):1-4.
 HUA Feng-chun.The applications of 11C-MET PET in brain tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):1-4.
点击复制

11C-METPET在脑肿瘤中的应用(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第1期
页码:
1-4
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The applications of 11C-MET PET in brain tumor
作者:
华逢春
200040 上海, 复旦大学附属华山医院核医学科
Author(s):
HUA Feng-chun
Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanhai 200040, China
关键词:
脑肿瘤正电子发射断层显像11C-蛋氨酸
Keywords:
brain tumorpositron emission tomography11C-methion
分类号:
R817.4
摘要:
11C-MET(11C-蛋氨酸)是目前用于肿瘤PET最多的氨基酸类显像剂之一,它能反映体内氨基酸的转运、肿瘤氨基酸的代谢及蛋白质的合成。11C-MET PET能用于脑肿瘤的诊断、区分肿瘤复发及放射性坏死,早期评价治疗效果,尤其对肿瘤周边组织及低度恶性肿瘤的诊断要优于18F-FDG PET、CT和MRI。
Abstract:
11C-methionine (MET), an amino acid, is the most widely used radiopharmaceutics which can reflect transport metabolism of amino acid in vivo, and synthesis of protein in tumor.11C-METPET can be used for evaluation of brain tumor:detection of tumor, differential diagnosis between recurrence and radiation necrosis and early evaluation of response to treatment.Especially, for the definition of tumor margin and detection of low-grade tumors, PET with 11C-MET is better than PET with 18F-FDG or other modalities such as CT and MRI.

参考文献/References:

[1] Weber WA, Wester Hi, Grosu AL, et al. O-(2-[18F] Flourothyl)-L-tyrosine and L-[methyl 11] methionine uptake in brain tumours:initial results of a comparative study[J]. Eur J Nucl Med, 2000, 27(5):542-549.
[2] Matheja P, Schober O.123I-IMT SPET:introducing another research tool into clinical neuro-oncology[J]. Eur J Nucl Med, 2001, 28(1):1-4.
[3] Roelcke U, Radu E, Ametamey S, et al. Association of rubidium and 11C-methionine uptake in braintumors measured by positron emission tomography[J]. J Neurooncol, 1996, 27(2):163-167.
[4] Jager PL, Vaalburg W, Pruim J, et al. Radiolabeledamino acids:basic aspects and clinical appacations in ontology[J]. J Nucl Med, 2001, 42(3):432-445.
[5] Derlon JM, Chapon F, Noel MH, et al. Non-invasive grading of oligodendrogliomas:correlations between in vivo metabolic pattern and histopathology[J]. Eur J Nucl Med, 2000, 27(7):778-787.
[6] Derlon JM, Petit-Taboue MC, Chapon F, et al.The in vivo metabolic pattern of low-grade brain gliomas:a positron emission tomographic study using 18F-fluorodeoxyglucose and 11C-L-methylmethionine[J]. Neurosurgery, 1997, 40(2):276-288
[7] Goldman S, Levivier M, Pirotte B, et al. Regional methionine and glucose uptake in high-grade gliomas:a comparative study on PET-guided stereotactic biopsy[J]. J Nucl Med, 1997, 38(9):1459-1462.
[8] Sato N, Suzuki M, Kuwata N, et al. Evaluation of the malignancy of glioma using 11-methionine positron emission tomography and proliferating cell nuclear antigen staining[J]. Neurosurg Rev, 1999, 22(4):210-214.
[9] Sasaki M, Kuwabara Y, Yoshida T, et al. A comparative study of thallium-201 SPET, carbon-11 methionine PET and fluorine-18 fluoodeoxyglucose PET for the differentiation of astrocytic tumours[J]. Eur J Nucl Med, 1998, 25(9):1261-1269.
[10] Nyberg G, Bergstrom M, Enblad P, et al. PET-methionine of skull base neuromas and meningiomas[J]. Acta Otolaryngol (Stockh), 1997, 117:482-489.
[11] Braga FJHN, Flamen P, Van Calenbergn F. 11-Cmethionine (MET) and 18-FDG PET for the evaluation of suspected recurrent brain tumours(SRBT)[J]. Eur J Nucl Med, 2000, 27(8):1145.
[12] Kaschten B, Stevenaert A, Sadzot B, et al. Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxy-glucose and/or carbon-11-methionine[J]. J Nucl Med, 1998, 39(5):778-785.
[13] Nuutinen J, Sonninen P, Leiikoinen P, et al. Radiotherapy treatment planning and long-term follow-up with[11C] methionine PET in patients with low-grade astrocytoma[J]. Int J Radiat Oncol Biol Phys, 2000,48(1):43-52.
[14] Roelcke U, Ammom KV, Hausmann O, et al. Operated low grade astrocytomas:a long term PET study on the effect of radiotherapy[J]. J Neurol Neurosury Psychiatry, 1999, 66:644-647.
[15] Gudjonsson O, Blomquist E, Lilja A, et al. Evaluation of the effect of high-energy proton irradiation treatment on meningiomas by means of 11C-L-methionine PET[J]. Eur J Nucl Med, 2000,27(12):1793-1799.
[16] Voges J, Herholz K, Holzer T, et al. 11-methionine and 18F-2-fluorodeoxyglucose position emission tomogrphy:a tool for diagnosis of cerebral glioma and monitoring after brachytherapy with 125I seeds[J]. Stereotaet Funet Nurosurg, 1997, 69(1-4pt2):129-135.
[17] Tsuyuguchi N, Sunada I, Iwai Y, et al. Investigation of false positive and false negative signs in methionine-PET[J]. Riv Neuroradiol, 1998,11(suppl 2):87-90.
[18] Tashima T, Moriaka T, Nishio S, et al. Delayed cerebral radionecrosis with a high uptake of 11-methionine on positron emission tomography and 201Tl-chloride on single-photon emission computed tomography[J]. Neuroradiology, 1998,40:435-438.

相似文献/References:

[1]邓大平,卢峰,孙洪强,等.颅脑肿瘤放射治疗时射野外器官吸收剂量体模法测量与分析[J].国际放射医学核医学杂志,2016,40(4):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
 Deng Daping,Lu Feng,Sun Hongqiang,et al.Test and analysis of out-of-field organ dose in intracranial tumor radiotherapy using phantom[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
[2]周惠君,董萍,沈国华,等.11C-蛋氨酸PET/CT显像在脑胶质瘤中的应用价值[J].国际放射医学核医学杂志,2015,39(2):161.[doi:10.3760/cma.j.issn.1673-4114.2015.02.013]
 Zhou Huijun,Dong Ping,Shen Guohua,et al.Value of 11C-methionine PET/CT imaging indiagnosing cerebral glioma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):161.[doi:10.3760/cma.j.issn.1673-4114.2015.02.013]
[3]杜芳芳,郭阳,姜炜.脑转移瘤的放射治疗进展[J].国际放射医学核医学杂志,2015,39(4):328.[doi:10.3760/cma.j.issn.1673-4114.2015.04.012]
 Du Fangfang,Guo Yang,Jiang Wei.Advances in radiotherapy of brain metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):328.[doi:10.3760/cma.j.issn.1673-4114.2015.04.012]
[4]潘亚菊.CT在颅脑疾病诊断中的应用[J].国际放射医学核医学杂志,2012,36(3):186.[doi:10.3760/cma.j.issn.1673-4114.2012.03.017]
 PAN Ya-ju.Application and advantages of CT in diagnosis of brain disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):186.[doi:10.3760/cma.j.issn.1673-4114.2012.03.017]
[5]李亚军,白人驹,高硕,等.兔VX2肺肿瘤PET-CT与血管生成的相关性研究[J].国际放射医学核医学杂志,2010,34(3):139.
 LI Ya-jun,BAI Ren-ju,GAO Shuo,et al.The correlation between PET-CT imaging and microvessed density in rabbit lung VX2 tumor model[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):139.
[6]黄喆敏,左传涛,管一晖.18F-氟脱氧葡萄糖的脑肿瘤PET[J].国际放射医学核医学杂志,2007,31(3):163.
 HUANG Zhe-min,ZUO Chuan-tao,GUAN Yi-hui.Non 18F-fluorodeoxyglucose PET imaging of brain tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):163.
[7]陈艳芳,杨天恩,曹永珍.放射性脑损伤和脑肿瘤复发的鉴别诊断[J].国际放射医学核医学杂志,2006,30(5):308.
 CHEN Yah-fang,YANG Tian-en,CAO Yong-zhen.Differentiation between brain radiation injury and brain tumor recurrence[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):308.
[8]姜炜.颅内生殖细胞瘤的放射治疗[J].国际放射医学核医学杂志,2006,30(6):362.
 JIANG Wei.Radiotherapy for intracranial germinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):362.
[9]陈跃.颅内肿瘤放射治疗后18F-氟代脱氧葡萄糖PET的临床意义[J].国际放射医学核医学杂志,2006,30(2):97.
 CHEN Yue.Clinical value of 18F-FDG PET after radiotherapy for intracerebral tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):97.
[10]蔡莉,李彦生.氟代脱氧葡萄糖与氨基酸PET在脑肿瘤中的对比研究[J].国际放射医学核医学杂志,2005,29(1):10.
 CAI Li,LI Yan-sheng.Comparison of 18F-FDG and amino acid PET imaging in brain tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(1):10.

备注/Memo

备注/Memo:
收稿日期:2001-6-27。
作者简介:华逢春(1973-),男,安徽安庆人,硕士研究生,主要从事PET的临床应用。
更新日期/Last Update: 1900-01-01