[1]林治栋.骨髓基质细胞及其辐射残留损伤[J].国际放射医学核医学杂志,2001,25(6):282-284.
　LIN Zhi-dong.Current development in the study of the bone marrow stroma cell and its radiation residual damage[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(6):282-284.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第6期
页码:
282-284
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Current development in the study of the bone marrow stroma cell and its radiation residual damage
作者:
林治栋
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
LIN Zhi-dong
Institute of Radiation Medicine, China Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
骨髓基质细胞; 细胞外基质; 辐射残留损伤; 生长因子
Keywords:
bone marrow stroma cell; microenvironment; residual damage; cytokine
分类号:
Q345+.21
摘要:
骨髓微环境特别是基质细胞对骨髓的造血起着重要的调控和支持作用。基质细胞与细胞外基质协同作用,并通过分泌众多细胞因子和表达多种粘附因子形成了一个调控造血细胞增殖和分化的网络体系。基质细胞以其较大的辐射抗性对造血系统辐射残留损伤的恢复发挥重要的作用。
Abstract:
A great supportive and regulatory role has been played by the bone marrow microenvironment, esp. its component, stroma cells. Bone marrow stroma cells function cooperating with their surrounding ECM form a complicate network regulating differentiation and proliferation of hematopoietic progenitor cells.The radiation resistance exhibited by stroma cells is critical for the recovery of hematopoietic progenitor cells from residual damage.

参考文献/References:

[1] Long MW, Wicke M.The hematopoietic microenvironment[M].Baltimore:Johns Hopkins university Press, 1993.158-234.
[2] Chute JP, Saini AA, Kampen RL.A comparative study of the cell cycle status and primitive cell adhesion molecule profile of human CD34+ cells cultured in stroma-free versus porcine microvascular endothilial cell cultures[J].Exp Hematol, 1999, 27(2):370-379.
[3] Koller MR, Oxender M, Jensen TC.Direct contact between CD34+ lin-cells and stroma induces a soluble activity that specifically increases primitive hematopoietic cell production[J].Exp Hematol, 1999, 27(4):734-741.
[4] Yamada M, Suzu S, Tanaka-Douzono M, et al.Effect of cytokines on the proliferation/differentiation of stroma-initiating cells[J].J Cell Physiol, 2000, 184(3):3511-3515.
[5] Keil F, Chen X.Effect of interleukin-3, stem cell factor and granulocyte-macrophage colony-stimulating factor on commited stem cells, long-term cells initiating cells and bome marrow stroma in a one-step long-term marrow culture[J].Ann Hematol, 2000, 79(5):243-248.
[6] Grande T, Bueren JA.Involvement of the bone marrow stroma in the residual hematopoietic damage indued by irradiation of adult and young mice[J], Exp Hematol, 1994, 22:1283-1287.
[7] Jacobsen K, Kravitz J, Kincade PW, et al.Adhesion receptors on bone marrow stromal cells:in vivo expession of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice[J].Blood, 1996, 87(1):73-82.
[8] Grande T, Gaitan S.Residual hematopoietic damage in adult and 8 day-old mice exposed to 7Gy of X-rays[J].Int J Radiat Biol, 1993, 63(1):59-67.

相似文献/References:

[1]高颖.辐射对骨髓造血微环境影响的研究进展[J].国际放射医学核医学杂志,2000,24(4):183.
　GAO Ying.Curent developments in the study of effects of irradiation on bone marrow haematopoietic microenvironment[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(6):183.

备注/Memo

备注/Memo:
收稿日期:2000-4-5。
作者简介:林治栋(1975-),男,辽宁沈阳人,中国医学科学院、中国协和医科大学放射医学研究所硕士研究生,主要从事造血微环境研究。
更新日期/Last Update: 1900-01-01