[1]谷晓云.核医学诊断操作中的亚细胞水平吸收剂量及其生物效应[J].国际放射医学核医学杂志,2001,25(4):165-168.
 GU Xiao-yun.Cellular dosimetry and biological conseuences caused by diagnostic nuclear medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(4):165-168.
点击复制

核医学诊断操作中的亚细胞水平吸收剂量及其生物效应(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第4期
页码:
165-168
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Cellular dosimetry and biological conseuences caused by diagnostic nuclear medicine
作者:
谷晓云
200032 上海, 复旦大学附属中山医院核医学科
Author(s):
GU Xiao-yun
Department of Nuclear Medicine of Zhongshan Hospital, Fudan University Medical College, Shanghai 200032, China
关键词:
亚细胞吸收剂量放射性药物俄歇电子
Keywords:
cellular dosimetryradiopharmaceuticalauger electron
分类号:
R817.4
摘要:
许多诊断用的放射性核素,在诊断过程中同时伴有俄歇电子发出,这些单能电子引起了亚细胞水平的剂量分布不均,并且当这些俄歇电子参入DNA时引起严重放射生物学毒性,其相对生物效应大于1.为此,根据放射性药物在亚细胞分布提出了恰当的剂量计算模型(细胞型或传统型MIRD),讨论了设计新的放射性诊断药物时核素的选择及其原则。
Abstract:
Most radionuclides used for diagnostic imaging emit Auger electrons (technetium-99m, iodine-125,indium-111 and thalliun-201), these emit numerous mono-energetic electrons responsible for dose heterogeneity at the cellular level. Radiobiological experiments show that the biological effects of Auger emitters incorporated into DNA can be severe with relative biological effectiveness greater than 1. This report proposes the most appropriate model for dosimetric computations (cellular or conven tonal) according to the subcellular distribution of radiotracers and discusses the radionuclide of choice and the general strategy used to design new diagnostic radiopharmaceuticals.

参考文献/References:

[1] Howell RW.Radiation spectra for Auger-electron emitting radionuclides:report No.2 of AAPM nuclear medicine task group No.6[J].Med Phys, 1992, 19:1372-1382.
[2] Stepanek J, Larsson B, Weinreich R.Auger electron spectra of radionuclides for therapy and diagnostics[J].Acta Oncol, 1996, 35:863-868.
[3] Sastry KSR.Biological effects of Auger emitter iodine-125[J].Med Phys, 1992, 19:1361-1370.
[4] Narra V R, Howell RW, Harapanhalli RS, et al.Radiotoxicity of some iodine-123, iodine-125 and iodine-131-labled compounds in mouse tests:implications for radiopharmaceutical design[J].J Nucl Med, 1992, 33:2196-2201.
[5] Faraggi M, Gardin I, Mmoretti JL, et al.Comparison of cellular and conventional dosimetry in assessing self-dose and cross-dose delivered to the cell nucleus by electron emissions of Tc-99 m, I-123, In-111, Ga-67 and Tl-201[J].Eur J Nucl Med, 1998, 25:205-214.
[6] Hartman T, Lundqvist H, Westlin JE, et al.Radiation doses to the cell nucleus in single cells and cells in micrometastases in targed therapy with 131-I labeled ligands or antibodies[J].Int J Radiat Oncol Biol Phys, 2000, 46(4):1025-1036.
[7] Spinelli F, Sare R, Milella M, et al.Technotium-99m hexamethylpropylene axnine oxine leucocyte scintigraphy in the differential diagnosis of cerebral abscesses[J].Eur J Nucl Med, 2000, 27(1):46-49.
[8] Garcferndez R, Lwasaki I, Acosta F, et al.Scintigraphy with erythrocytes labelled in vitro with 99Tcm compared with 111In-octreptide in the detection of carotid glomus[J].Rev Invest Clin, 2000, 52(1):25-30.
[9] Narra V R, Sastry KRS, Goddu SM, et al.Relative biological effectiveness of Tc-99m radio-pharmaceuticals[J].Med Phys, 1994, 21:1921-1926.
[10] de Labriolle-Vayler C, Colas-Linhart N, Sala-Trepat M, et al.Biological consequence of the heterogeneous irradiation of lymphocytes during technetium-99m hexamethylpropylene amine oxime white blood cells labeling[J].Eur J Nucl Med, 1998, 25:1423-1428.
[11] Marjorie S, Nicole C, Colas-Linhart, et al.Heteroge-neous distribution of technetium-99m-labeled micro-spheres in rat lungs:microautoradiographic evidence and dosimetric consequences[J].J Nucl Med, 1997, 38:650-654.
[12] Puncher MRB, Blower PJ.Fronzen section microau-toradiography in the study of radionuclide targeting:application to indium-111-oxime-labled leucocytes[J].J Nucl Med, 1995, 36:499-505.
[13] Gardin I, Faraggi M, Huc E, et al.Modelling of the relationship between cell dimensions and mean dose delivered to the cell nucleus:application to five radionuclides used in nuclear medicine[J].Phys Med Biol, 1995, 40:1001-1014.
[14] Gardin I, Colas-Linhart N, Petiet A, et al.dosimetryat the cellular level of kupffer cells after technetium-99m-sulphur colloid injection[J].J Nucl Med, 1992, 33:380-384.
[15] Ernst M, Freed M E, Zametkin AJ.Health hazards of radiation exposure in the context of brain imaging research:special consideration for children[J].J Nucl Med, 1998, 39:689-698.

相似文献/References:

[1]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
 Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[2]甘红梅,乔晋萍,孔爱英,等.正电子放射性显像剂代谢及其研究方法进展[J].国际放射医学核医学杂志,2010,34(2):65.[doi:10.3760/cma.j.issn.1673-4114.2010.02.001]
 GAN Hong-mei,QIAO Jin-ping,KONG Ai-ying,et al.The progress on researching method and metabolism of positron radiopharmaceutical[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):65.[doi:10.3760/cma.j.issn.1673-4114.2010.02.001]
[3]顾涛颖,石洪成.放射性药物治疗肿瘤骨转移性骨痛的作用[J].国际放射医学核医学杂志,2010,34(2):88.[doi:10.3760/cma.j.issn.1673-4114.2010.02.006]
 GU Tao-ying,SHI Hong-cheng.The use of radiopharmaceuticals for metastatic bone pain in cancer patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):88.[doi:10.3760/cma.j.issn.1673-4114.2010.02.006]
[4]周雪,乔晋萍,孔爱英,等.受体结合实验及其在放射性显像剂研究中的应用进展[J].国际放射医学核医学杂志,2010,34(6):321.[doi:10.3760/cma.j.issn.1673-4114,2010.06.001]
 ZHOU Xue,QIAO Jin-ping,KONG Ai-ying,et al.Progress on the application of ligand receptor binding assays in radiopharmaceuticals[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):321.[doi:10.3760/cma.j.issn.1673-4114,2010.06.001]
[5]彭添兴,吴华.18F-氟脱氧葡萄糖以外新型PET肿瘤显像剂[J].国际放射医学核医学杂志,2007,31(1):9.
 PENG Tian-xing,WU Hua.New type PET imaging agent excluding 18F-fluorodeoxyglucose in oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):9.
[6]范我.用于肿瘤治疗的放射性药物[J].国际放射医学核医学杂志,2004,28(1):21.
 FAN Wo.Radiopharmaceuticals for tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(4):21.
[7]陈璟,吴华.核素炎症显像的研究进展[J].国际放射医学核医学杂志,2003,27(3):107.
 CHEN Jing,WU Hua.The development of radionuclide imaging of infection and inflammation[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):107.
[8]杨建权,李晔,张现忠.基于小分子肽的放射性药物[J].国际放射医学核医学杂志,2003,27(4):157.
 YANG Jian-quan,LI Ye,ZHANG Xian-zhnng.Peptide as carrier for diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):157.
[9]袁志斌.获得FDA批准的放射性药物[J].国际放射医学核医学杂志,2000,24(4):161.
 YUAN Zhi-bin.FDA approved radiopharmaceuticals[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):161.
[10]弓全胜,夏振民.放射性药物的给药后归宿[J].国际放射医学核医学杂志,1998,22(4):167.

备注/Memo

备注/Memo:
收稿日期:2000/12/25。
作者简介:谷晓云(1972-),女,江苏连云港人,复旦大学医学院附属中山医院核医学科硕士研究生,主要从事肿瘤核医学治疗研究。
更新日期/Last Update: 1900-01-01