[1]郝林军,王雪梅,郝晋.99Tcm-RGD显像在类风湿性关节炎血管形成早期诊断的初步探讨[J].国际放射医学核医学杂志,2015,39(2):184-187.[doi:10.3760/cma.i.issn.1673-4114.2015.02.018]
　Hao Linjun,Wang Xuemei,Hao Jin.Applications of 99Tcm-RGD for angiogenesis in early diagnosis of rheumatoid arthritis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):184-187.[doi:10.3760/cma.i.issn.1673-4114.2015.02.018]
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99Tcm-RGD显像在类风湿性关节炎血管形成早期诊断的初步探讨(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第2期
页码:
184-187
栏目:
出版日期:
2015-03-25

文章信息/Info

Title:
Applications of 99Tcm-RGD for angiogenesis in early diagnosis of rheumatoid arthritis
作者:
郝林军1;  王雪梅2;  郝晋3
1. 内蒙古医科大学附属医院保健中心, 呼和浩特, 010050;
2. 内蒙古医科大学附属医院核医学科, 呼和浩特, 010050;
3. 内蒙古医科大学2013级检验专业, 呼和浩特, 010050
Author(s):
Hao Linjun1;  Wang Xuemei2;  Hao Jin3
Center of Health Care, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China
关键词:
关节炎; 类风湿; 新生血管形成; RGD显像
Keywords:
Arthritis; rheumatoid; Angiogenesis; RGD imaging
DOI:
10.3760/cma.i.issn.1673-4114.2015.02.018
摘要:
滑膜血管翳形成是类风湿性关节炎(RA)最基本、最重要的病理表现,可导致软骨和骨破坏及关节重塑,最终导致关节畸形、功能丧失。其中,血管形成在血管翳的侵蚀和破坏过程中发挥了重要的作用,增强了血管翳的侵袭性,促进了软骨和骨破坏。血管形成从RA病程的早期便开始作用并贯穿整个病程。因而观察血管形成对于RA的早期诊断、活动期判断、疗效观察和预后判断均有重要意义。99Tcm标记精氨酸-甘氨酸-天冬氨酸(RGD)的多肽是一种能与整合素αvβ3受体有高度的选择性和亲和力,并能在体反映血管形成情况的显像剂。因而可以利用99Tcm-RGD SPECT观察RA的滑膜血管翳形成和发展过程及血管形成拮抗剂抑制RA血管形成的规律,从而为RA的生物治疗提供更多的理论依据并寻找到更多的新靶向治疗药物。
Abstract:
Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with 99Tcmlabeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.

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备注/Memo

备注/Memo:
收稿日期:2014-07-05。
基金项目:国家自然科学基金(81260224);2013年自治区应用技术研究与开发资金项目(20130401);内蒙古医科大学附属医院重大项目(NYFYZD2012011)
通讯作者:王雪梅,Email:wangxuemei201010@163.com
更新日期/Last Update: 1900-01-01