[1]薛秀青,苏成海.99Tc-亚甲基二膦酸盐的临床应用研究进展[J].国际放射医学核医学杂志,2010,34(5):285-288.[doi:10.3760/cma.j.issn.1673-4114.2010.05.008]
　XUE Xiu-qing,SU Cheng-hai.Progress of 99Tc-methylenediphosphonate in clinical applications[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):285-288.[doi:10.3760/cma.j.issn.1673-4114.2010.05.008]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第5期
页码:
285-288
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress of 99Tc-methylenediphosphonate in clinical applications
作者:
薛秀青;  苏成海
215006, 苏州大学附属第一医院核医学科
Author(s):
XUE Xiu-qing;  SU Cheng-hai
Department of Nuclear Medicine, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
关键词:
关节炎; 类风湿; 脊柱炎; 强制性; Graves眼病; 99Tc-亚甲基二膦酸盐
Keywords:
Arthritis; rheumatoid; Spondylitis; ankylosing; Grave ophthalmopathy; 99Tc-methylenediphosphonate
DOI:
10.3760/cma.j.issn.1673-4114.2010.05.008
摘要:
99Tc-亚甲基二瞵酸盐(99Tc-MDP)可以抑制炎性反应,发挥抗炎、抗风湿作用;能抑制前列腺素的合成,具有明显镇痛作用。此外,99Tc-MDP还可通过调节人体自身免疫及调节骨代谢而发挥作用。临床上99Tc-MDP主治类风湿性关节炎、强直性脊柱炎、甲亢伴浸润性突眼等自身免疫性疾病,对癌转移痛、股骨头坏死及骨质疏松也有较好疗效。
Abstract:
The main ingredient of 99Tc-methylenediphosphonate(99Tc-MDP)is chelates which formed by the technetium 99Tc after stannous reduction and methylenediphosphonate. Studies have shown that 99TcMDP can inhibit the inflammatory response, play anti-inflammatory, anti-rheumatic effect, it also have significant analgesic effect by inhibit prostaglandin synthesis. In addition,99Tc-MDP also can regulate the body’s own immune and bone metabolism to treat the corresponding diseases. Treating rheumatoid arthritis,ankylosing spondylitis, Graves’ ophthalmopathy and other autoinunne diseases. It also has a good effect on pain which is caused by cancer, femoral head necrosis and osteoporosis. Review progress of 99Tc-MDP in clinical applications.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2010-06-21。
通讯作者:苏成海,E-mail:su323@126.com
更新日期/Last Update: 1900-01-01