[1]高云朝.恶性胶质瘤的放射免疫治疗[J].国际放射医学核医学杂志,2004,28(4):149-152.
 GAO Yun-chao.Radioimmunotherapy for malignant glioma[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(4):149-152.
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恶性胶质瘤的放射免疫治疗(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第4期
页码:
149-152
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Radioimmunotherapy for malignant glioma
作者:
高云朝
200040 上海, 复旦大学附属华山医院核医学科
Author(s):
GAO Yun-chao
Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
关键词:
胶质瘤放射免疫治疗抗腱生蛋白单抗
Keywords:
gliomaradioimmunotherapyanti-tenascin monoclonal antibodies
分类号:
R817.5
摘要:
恶性胶质瘤以手术切除为主,辅以放疗和化疗,在此基础上再进行适当的放射免疫治疗,可进一步延长生存期。131I和90Y标记的抗腱生蛋白抗体用于恶性胶质瘤的实验和临床Ⅰ、Ⅱ期治疗研究获得了满意效果。
Abstract:
Malignant glioma is treated mainly by surgery with chemotherapy and external radiotherapy as adjuvant remedies. Survival time can be prolonged if appropriate radioimmunotherapy is employed as another concurrent alternative. Per-clinical, clinical phase I and II studies of 131I and 90Y labeled anti-tenascin monoclonal antibodies in the treatment of malignant glioma have resulted in satisfactory therapeutic efficacy.

参考文献/References:

1 Riva P,Franceschi G,Frattarelli M,et al.131I radioconjugated antibodies for the locoregional radioimmunotherapy of high-grade malig-nant glioma:Phase I and II Study[J].Acta Oncologica,1999,38(3):351-359.
2 Riva P,Franceschi G,Riva N,et al.Role of nuclear medicine in the treatment of malignant gliomas:the locoregional radioimmunotherapy approach[J].Eur J Nucl Med,2000,27(5):601-609.
3 Santis RD,Anastasi AM,alessio VD.et al. Novel antitenascin antibody with increased tumour localisation for pretargeted antibodyguided radioimmunotherapy (PAGRITRR)[J].Br J Cancer,2003,88(07):996-1003.
4 Akabani G,Cokgor I,Coleman RE,et al.Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy[J].Int J Radia Oncol Biol Phys,2000,46(4):947-958.
5 Cokgor I,Akabani G,Kuan CT,et al.Phase I trial results of iodine-131 labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas[J].J Clin Oncol,2000,18(22):3862-3872.
6 Goetz C,Rive P,Poepperl G,et al.Locoregional radioimmunotherapy in selected patients with malignant glioma:experience,side effects and survival times[J].J Neuro Oncol,2003,62:321-328.
7 Mahesparan R,Read TA,Lund-Johansen M,et al.Expression of extracellular matrix components in a highly infiltrative in vivo glioma model[J].Acta Neuropathologica,2003,105(1):49-57.
8 Akabani G,Reist CJ,Cokgor I,et al.Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors[J]. J Nucl Med,1999,40(4):631-638.
9 Hasegawa K,Yoshida T,Matsumoto K,et al.Differential expression of tenascin-C and tenascin-X in human astrocytomas[J].Acta Neu-ropathologica,1997,93:431-437.
10 Popperl G,Gotz C,Gildehaus FJ,et al.Initial experiences with adjuvant locoregional radioimmunotherapy using 131I-labeled monoclonal antibodies against tenascin(BC-4) for treatment of glioma (WHO IIIand TV)[J].Nuklearmedizin,2002,41(3):120-128.
11 Reardon DA,Akabani G,Edward CR,et al.Phase II trial of murine 131I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas[J].J Clin Oncol,2002,20(5):1389-1397.
12 Hopkins K,Chandler C,Eatough J,et al.Direct injection of 90Y-MoAbs into glioma tumor resection cavities leads to limited diffusion of the radioimmunoconjugates into normal brain parenchyma:a model to estimate absorbed radiation dose[J].Int J Radiat Oncol Biol Phys,1998,40(4):835-844.
13 Riva P,Franceschi G,Frattarelli M,et al.Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y:a Phase I study[J].Clin Cancer Res,1999,5:3275s-3280s.
14 Paganelli G,Grana C,Chinol M,et al.Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin[J].Eur J Nucl Med,1999,26(4):348-357.
15 Grana C,Chinol M,Robertson C.Pretargeted adjuvant radioimmunotherapy with yttrium-90-biotin in malignant glioma patients:a pilot study[J].Br J Cancer,2002,86:207-212.
16 Hauck ML,Larsen RH,Welsh PC,et al.Cytotoxicity of α-particle emitting astatine-211-labelled antibody in tumour spheroids:no effect of hyperthermia[J].Br J Cancer,1998,77(5):753-759.
17 Zalutsky MR,Zhao XG,Alston KL,et al.High-level production of α-particle emitting 211At and preparation of 211At labeled antibodies for clinical use[J].J Nucl Med,2001,42(10):1508-1515.
18 Imam SK.Advancement in cancer therapy with alpha-emitters:a review[J].Int J Radiat Oncol Biol Phys,2001,51(1):271-278.

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备注/Memo

备注/Memo:
收稿日期:2003-11-01。
更新日期/Last Update: 1900-01-01