[1]葛素娟.甲状腺癌术后131I治疗[J].国际放射医学核医学杂志,2002,26(4):163-164,168.
 GE Su-juan.131I therapy of thyroid cancer after surgery[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):163-164,168.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第4期
页码:
163-164,168
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
131I therapy of thyroid cancer after surgery
作者:
葛素娟
473012 南阳, 河南省南阳市第 二人民医院放疫室
Author(s):
GE Su-juan
The Second People’s Hospital of Nanyang, Henan Nanyang 473012, China
关键词:
甲状腺肿瘤131I治疗钠/碘同向转运体甲状腺过氧化物酶维加酸
Keywords:
thyroiol cancer131I therapysodium/iodide symporterthyro peroxidaseretinoide
分类号:
R817.5
摘要:
甲状腺癌确诊后,经典的治疗方法是近全切除术后加131I治疗。研究表明,NIS(钠/碘同向转运体)具有聚碘能力,而TPO(甲状腺过氧化物酶)能抑制碘从细胞中流出,NIS和TPC基因联合转染肿瘤细胞介导131I治疗有可能成为一种新的治疗方法;维加酸可诱导失分化肿瘤细胞的摄碘能力恢复或提高,也有利于131I治疗。
Abstract:
The classic therapy of metastatic well differented thyroid cancer is administration of 131I after subtotal thy-roectomy.The sodium/iodine symporter (NIS)mediates the active transport of iodine into thyroid cells,while the thy-roperoxidase (TPO)suppresses the out-flow of iodine from thyroid cells.As a result,a new potential approach has been develepted with co-transfection of NIS and TPO genes to thyroid cancer cells,which can enhance the results of radioio-dine.Retinoide is also useful to 131I therapy for it can induce non-differented thyroid cancer cells to well-differnted cells to increase radioiodine uptake.

参考文献/References:

[1] Mazzaferri EL. An overview of the management of papillary and follicular thyroid carcinoma[J]. Thyroid, 1999, 9:421-427.
[2] Koong S, Reynolds JC, Movius EG, et al. Lithium as a potential adjuvant to 131I theraphy of metastatic well-differentiated thyroid carcinoma[J]. J Clin Endocrinol Metab, 1999, 84:912-916.
[3] Arturi F, Russo D, Schlumberger M, et al. Iodide symporter gene expression in human thyroid tumors[J]. J Clin Endocrinol Metab, 1998, 83:2493-2496.
[4] Shimura H, Haraguchi K, Miyazaki A, et al. Iodide uptake and experimental 131I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na+/I- symproter gene[J]. Endocrinology, 1997, 138:4493-4496.
[5] Franke WG, Zophel K, Wunderlich GR, et al. Thyroperoxidase:a tumor marker for post-therapeutic follow-up of differentiated thyroid carcinomas? Results of a time course study[J]. Cancer Detect Prey, 2000, 24(6):524-530.
[6] Schmutzler C, Winzer R, Meissner WJ, et al. Retinoic acid increase sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells[J]. Biochem Biophys Res Commun, 1997, 240:832-838.
[7] Simon D, Koehrle J, Reiners C, et al. Redifferentiation theraphy with retinoide:therapeutic option for advanced follicular and papillary thyroid carcinoma[J]. World J Surg, 1998, 22:569-574.
[8] Grunwald F, Menzel C, Bender H, et al. Redifferentiation therapy-induced radioiodine uptake in thyroid cancer[J]. J Nucl Med, 1998, 39:1903-1906.

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备注/Memo

备注/Memo:
收稿日期:2002-07-06。
作者简介:葛素娟(1956-),女,河南孟州人,主管检验师,主要从事临床核医学研究。
更新日期/Last Update: 1900-01-01