[1]张海琴.中枢多巴胺转运蛋白显像剂99TcmTRODAT-1[J].国际放射医学核医学杂志,2001,25(3):100-103.
　ZHANG Hai-qin.99Tcm-TRODAT-1: the central dopamine transporter imaging agent[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(3):100-103.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第3期
页码:
100-103
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
99Tcm-TRODAT-1: the central dopamine transporter imaging agent
作者:
张海琴
510089 广东广州, 广州中山医科大学附属第一医院核医学科
Author(s):
ZHANG Hai-qin
Department of Nuclear Medicine, The First Affiliated Hospitai of Sun Yat Sen University of Medical Science, Guangzhou 510089, China
关键词:
99Tcm-TRODAT-1; 多巴胺转运蛋白; 单光子断层显像; 帕金森病
Keywords:
99Tcm-TRODAT-1; dopamine transporter; SPECT; Parkinson’s disease
分类号:
R817.9
摘要:
99Tcm-TRODAT-1是一种新型中枢多巴胺转运蛋白显像剂,其SPECT显像在帕金森氏病的早期诊断中具有重要的临床价值。文章综述了近年来99Tcm-TRODAT-1的生化及其标记制备、动物实验、显像方案和临床前研究方面的进展,展示了99Tcm-TRODAT-1在临床有良好的应用前景。
Abstract:
99Tcm-TRODAT-1 is a novel technetium-99m complex as a dopamine transporter imaging agent.The imaging of SPECT with it will have an important value in the early diagnosis of Parkinson’s disease. This article reviews the progress of this promising agent.

参考文献/References:

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[8] Kung M P,Stevenson DA,Plossl K,et al.[99Tcm]TRODAT-1:a novel technetium-99m complex as a dopamine transporter imaging agent[J].Eur J Nucl Med,1997,24:372-380.
[9] Kushner SA,Mc Elgin W T,Kung M P,et al.Kinetic modeling of [99mTc] TRODAT-1:a dopamine trans-porter imaging agent[J].JNucl Med,1999,40:150-158.
[10] Mozley PD,Stubbs JB,Plossl K,et al.Biodistribution and dosimetry of TRODAT-1:technetium-99m tropane for imaging dopamine transporters[J].J Nucl Med,1998,39:2069-2076.
[11] Choi SR,Kung MP,Plossl K,et al.An improved kit formulation of a dopamine transporter imaging agent:[Tc-99m] TRODAT-1[J].Nucl Med Biol,1999,26:461-466.
[12] Meegalla SK,Plossol K,Kung M P,et al.Specificity of diastereomers of 99mTc-TRODAT-1 as dopamine transporter imaging agents[J].J Med Chem,1997,40:9-17.
[13] Fang P,Wu CY,Liu Zhen-guo,et al.The preclinical pharmacologic study of dopamine transporter imagingagent 99mTc-TRODAT-1[J].Nucl Med Biol,2000,27:69-75.
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备注/Memo

备注/Memo:
收稿日期:2000/10/24。
作者简介:张海琴(1975-),女,广东人,广州中山医科大学附属第一医院核医学科硕士研究生,主要从事核素脑功能显像研究。
更新日期/Last Update: 1900-01-01