[1]欧阳伟.心肌灌注显像剂:99Tcm-N-NOET[J].国际放射医学核医学杂志,2001,25(3):103-106.
 OU Yang-wei.A myocardial perfusion imaging agent: 99Tcm-N-NOET[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(3):103-106.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第3期
页码:
103-106
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
A myocardial perfusion imaging agent: 99Tcm-N-NOET
作者:
欧阳伟
510282 广州, 第一军医大学珠江医院核医学科
Author(s):
OU Yang-wei
Department of unclear medicine, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, China
关键词:
99Tcm-N-NOET心肌灌注显像对比研究
Keywords:
technetium-99m-N-NOETmyocardial perfusion imaging201-thalliumcomparative study
分类号:
R817.9
摘要:
99Tcm-N-NOET{双[N-乙氧,N-乙基(二硫代氨基甲酸脂)氮化锝](V)}是一种锝标记中性亲脂性心肌灌注显像剂,具有心肌首过摄取率高、心肌滞留时间长之优点。其心肌摄取部位在细胞膜,且摄取不依赖于能量。L型钙通道阻滞剂能影响其心肌摄取。99Tcm-N-NOET不仅具有201Tl类似的心肌再分布,而且其心肌灌注显像在诊断冠状动脉疾病的敏感性和特异性方面与201Tl类似。
Abstract:
Bis [N-ethoxy, N-ethyl (dithiocarbamato)] nitrido Tc (V) (99Tcm-N-NOET) is a neutral lipophilic tech-netium agent of myocardial perfusion presenting the high first-pass myocardial uptake and long myocardial retention. The location of 99Tcm-N-NOET myocardial uptake is on cell membranes, and its myocardial uptake is not en-ergy-dependent, which is affected by L-type calcium channel inhibitor.99Tcm-N-NOET not only has a myocardial redistribution equivalent to 201Tl, the sensitivity and specificity of its myocardial perfusion imaging in detecting coronary artery disease but also are similar to 201Tl.

参考文献/References:

[1] Ghezzi C,Fagret D,Arvieux CC,et al.Myocardial kinetics of TcN-NOET:a neutral lipophilic complex tracer of regional myocardal blood flow[J].J Nucl Med,1995,36(6):1069-1077.
[2] Riou L,Ghezzi C,Mouton O,et al.Cellular uptake mechanisms of 99Tcm N-NOET in cardiomyocytes from newborn rats:calcium channel interaction[J].Circu-lation,1998,98(23):2591-2597.
[3] Fagret D,Marie PY,Brunotte F,et al.Myocardial perfusion imaging with technetium-99m-TcNOET:comparison with thallium-201 and coronary angioga-phy[J].JNucl Med,1995,36(6):936-943.
[4] Demaimay F,Dazord L,Roucoux A,et al.Rhenium-188 and technetium-99m nitridobis (N-ethoxy-N-ethyldithiocarbamate)leucocyte labelling radiopharma-ceuticals:[188ReN(NOET)2] and[99mTc N(NOET)2],NOET=Et(EtO)NCS2:their in vitro localization and chemical behaviour[J].Nucl Med Biol,1997,24(8):701-705.
[5] Fang P,Wang BC,Wu CY,et al.Pharmacology study of the neutral myocardial imaging agent tech-netium-99m-N (NOEt) 2[J].J Nucl Med Technol,1999,27(1):54-56.
[6] Vanzetto G,Calnon DA,Ruiz M,et al.Myocardial uptake and redistribution of 99mTc-NOET in dogs with either sustained coronary low flow or transient coronary occlusion:comparison with 201Tl and my-ocardial blood flow[J].Circulation,1997,96(7):2325-2331.
[7] Pasqualini R,Duatti A,Bellande E,et al.Bis (dithio-carbamato) nitrido technetium-99m radiopharma-ceuticals:a class of neutral myocardial imaging agents[J].J Nucl Med,1994,35(2):334-341.
[8] Uccelli L,Giganti M,Duatti A,et al.Subcellular dis-tribution of technetium-99m-N-NOEt in rat myocardi-um[J].JNucl Med,1995,36(11):2075-2079.
[9] Johnson G,Allton IL,Nguyen KN,et al.Clearance of technetium 99m N-NOET in normal,ischmic-reper-fused,and membrane-disrupted myocardium[J].J Nucl Cardiol,1996,3(1):42-54.
[10] Moisan A,Pasqualini R,Devillers A,et al.Granulo-cyte cell labelling with TcN-NOET[A].Radiolabeled Blood Elements:Recent Advances in Techniques and Applications[C].New York:Plenum Press,1994,262:33-37.
[11] Rosenbaum AF,McGoron AJ,Millard RW,et al.Uptake of seven myocardial tracers during increased myocardial blood flow by dobutamine infusion[J].In-vest Radiol,1999,34(2):91-98.
[12] Meleca MJ,McGoron AJ,Gerson MC,et al.Flow versus uptake comparisons of thallium-201 with tech-netium-99m perfusion tracers in a canine model of my-ocardial ischemia[J].J Nucl Med,1997,38(12):1847-1856.
[13] Johnson G,Nguyen KN,Liu Z,et al.Planar imagingof 99Tcm-labeled (bis (N-etboxy,N-ethyl dithiocarba-mato) nitrido technetium[Ⅴ]can detect resting is-chemia[J].J Nucl Cardiol,1997,4(3):217-225.
[14] Johnson G,Nguyen KN,Pasqualini R,et al.Interac-tion of technetium-99m-N-NOET with blood ele-ments:potential mechanism of myocardial redistribu-tion[J].J Nucl Med,1997,38(1):138-143.

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备注/Memo

备注/Memo:
收稿日期:2000/2/7。
作者简介:欧阳伟(1963年-),男,江西务源人,第一军医大学珠江医院核医学科主治医师,讲师,医学硕士,主要从事临床核心脏病学的研究。
更新日期/Last Update: 1900-01-01