[1]田丛娜,魏红星,张晓丽.PET心肌灌注显像测定心肌血流量及冠状动脉血流储备的研究进展[J].国际放射医学核医学杂志,2012,36(5):274-279.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.004]
 TIAN Cong-na,WEI Hong-xing,ZHANG Xiao-li.Progress of myocardial blood flow and coronary flow reserve measurement using PET myocardial perfusion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(5):274-279.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.004]
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PET心肌灌注显像测定心肌血流量及冠状动脉血流储备的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第5期
页码:
274-279
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress of myocardial blood flow and coronary flow reserve measurement using PET myocardial perfusion imaging
作者:
田丛娜 魏红星 张晓丽
国家心血管病中心, 阜外心血管病医院, 心血管疾病国家重点实验室核医学科, 北京协和医学院中国医学科学院, 北京 100037
Author(s):
TIAN Cong-na WEI Hong-xing ZHANG Xiao-li
Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
关键词:
正电子发射断层显像术心肌灌注显像冠状动脉循环冠状动脉血流储备心肌血流量
Keywords:
positron-emission tomographyMyocardial peffusion imagingCoronary circulationCoronary flow reserveMyocardial blood flow
DOI:
10.3760/cnla.j.issn.1673-4114.2012.05.004
摘要:
PET心肌灌注显像可绝对定量测定局部心肌血流量(MBF)和冠状动脉血流储备(CFR).由于显像剂半衰期短,允许在短时间内重复进行PET心肌灌注显像,获得静息态、冷加压试验和药物负荷试验等不同状态下的MBF,进而评价冠状动脉血管内皮依赖性和非依赖性的CFR功能.在早期诊断冠心病,准确诊断冠状动脉多支病变,评价微血管病变,早期检测冠状动脉内皮细胞功能异常及CFR功能的异常,估测预后,帮助临床治疗方案的制定以及检测疗效等方面,PET心肌灌注显像有重要的临床价值.该文将介绍PET心肌灌注显像相关知识及其在心血管领域的主要应用.
Abstract:
PET myocardial perfusion imaging permits the measurement of regional myocardial blood flow (MBF) and coronary flow reserve (CFR) in absolute units.The short physical half-life of the flow radiotracers used for these measurements allows repeatedly operating PET myocardial perfusion imaging during the same study session and thus,assessment of MBF at baseline,during cold pressor testing and pharmacologic vasodilation,which contributes to a comprehensive assessment of the endothelium-dependent and endothelium-independent CFR function.Therefore,such measurements of MBF could serve as an important tool to detect early stages of the development of coronary artery disease,multi-vessel coronary artery disease and microvascular disease,indicate an impairment of endothelium-dependent coronary circulatory function,provide predictive information for future cardiovascular events,and contribute to the clinical treatment programs development and therapeutic efficiency tcsting.The primary technical aspccts and clinical applications of PET myocardial perfusion imaging are introduced in this paper.

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备注/Memo

备注/Memo:
收稿日期:2012-07-09。
通讯作者:张晓(Email:xlzhang416@gmail.com)
更新日期/Last Update: 1900-01-01