[1]王振光,韩瑜.肺肉芽肿性炎正电子核素显像机制与影像特征[J].国际放射医学核医学杂志,2015,39(3):264-267.[doi:10.3760/cma.j.issn.1673-4114.2015.03.017]
　Wang Zhenguang,Han Yu.Mechanism and performance of position radionulide imaging in lung granuloma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):264-267.[doi:10.3760/cma.j.issn.1673-4114.2015.03.017]
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肺肉芽肿性炎正电子核素显像机制与影像特征(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第3期
页码:
264-267
栏目:
出版日期:
2015-05-25

文章信息/Info

Title:
Mechanism and performance of position radionulide imaging in lung granuloma
作者:
王振光1;  韩瑜2
1. 青岛大学附属医院PET/CT中心, 青岛, 266100;
2. 青岛大学医学院核医学专业, 青岛, 266100
Author(s):
Wang Zhenguang1;  Han Yu2
PET/CT Center, the Affiliated Hospital of Qingdao University, Qingdao 266100, China
关键词:
肺; 肉芽肿; 正电子发射断层显像术; 体层摄影术; X线计算机; 假阳性
Keywords:
Lung; Granuloma; Positron-emission tomography; Tomography;  X-ray computed; False positives
DOI:
10.3760/cma.j.issn.1673-4114.2015.03.017
摘要:
18F-FDG PET/CT在临床肿瘤诊断中被广泛应用,在鉴别肺良恶性病变中有较大价值。但是18F-FDG并非恶性肿瘤的特异性显像剂,代谢旺盛的炎性细胞(如巨噬细胞、淋巴细胞、嗜酸性粒细胞等)也可表现为18F-FDG高摄取。肺肉芽肿性炎的病理特点主要表现为大量代谢旺盛的炎性细胞浸润,所以肺肉芽肿性炎是导致18F-FDG PET/CT假阳性的主要病变。笔者就肺肉芽肿性炎的PET/CT表现、机制等方面进行综述,以提高PET/CT在肺部肿瘤鉴别诊断中的准确率。
Abstract:
18F-FDG PET/CT has been widely used to diagnose benign and malignant lung tumors. 18F-FDG is not a targeted tumor malignancy indicator because highly metabolic inflammatory cells,such as macrophages,lymphocytes,and eosinophils,also exhibit high 18F-FDG uptake.Granulomatous lung inflammation is pathologically characterized by a large amount of metabolic inflammatory cell infiltration and is therefore the leading cause of false positive 18F-FDG PET/CT uptake.This review aims to improve the accuracy of 18F-FDG PET/CT technique in lung tumor diagnosis and help readers understand PET/CT technique and the mechanism of granulomatous lung inflammation.

参考文献/References:

[1] Sebro R, Aparici CM, Hernandez-Pampaloni M. FDG PET/CT eva-luation of pathologically proven pulmonary lesions in an area of high endemic granulomatous disease[J]. Ann Nucl Med, 2013, 27(4):400-405.
[2] Goo JM, Im JG, Do KH, et al. Pulmonary tuberculoma evaluated by means of FDG PET:findings in 10 cases[J]. Radiology, 2000, 216(1):117-121.
[3] 汪敏, 徐友平. CT结合PET/CT显像诊断孤立性肺结节误诊原因分析[J]. 实用医学杂志, 2013, 29(12):2005-2007.
[4] Davis SL, Nuermberger EL, Um PK, et al. Noninvasive pulmonary[18F]-2-fluoro-deoxy-D-glucose positron emission tomography corre-lates with bactericidal activity of tuberculosis drug treatment[J]. Antimicrob Agents Chemother, 2009, 53(11):4879-4884.
[5] Macdonald K, Searle J, Lyburn I. The role of dual time point FDG PET imaging in the evaluation of solitary pulmonary nodules with an initial standard uptake value less than 2.5[J]. Clin Radiol, 2011, 66(3):244-250.
[6] 田蓉, 田野, 李芳兰, 等. 结核病高发地区18F-FDG PET/CT双期扫描诊断孤立性肺结节[J]. 四川医学, 2012, 33(6):1071-1073.
[7] Tian J, Yang X, Yu L, et al. A multicenter clinical trial on the diag-nostic value of dual-tracer PET/CT in pulmonary lesions using 3’-deoxy-3’-18F-fluorothymidine and 18F-FDG[J]. J Nucl Med, 2008, 49(2):186-194.
[8] Igai H, Gotoh M, Yokomise H. Computed to mography (CT)and positron emission tomography with[18F] fluoro-2-deoxy-D-glucose(FDG-PET) images of pulmonary cryptococcosis mimicking lung cancer[J]. Eur J Cardiothorac Surg, 2006, 30(6):837-839.
[9] Huang CJ, You DL, Lee PI, et al. Characteristics of integrated 18F-FDG PET/CT in Pulmonary Cryptococcosis[J]. Acta Radiol, 2009, 50(4):374-378.
[10] Choe YH, Moon H, Park SJ, et al. Pulmonary cryptococcosis in asymptomatic immunocompetent hosts[J]. Scand J Infect Dis, 2009, 41(8):602-607.
[11] Kishi K, Homma S, Kurosaki A, et al. Clinical features and high-resolution CT findings of pulmonary cryptococcosis in non-AIDS patients[J]. Respir Med, 2006, 100(5):807-812.
[12] 陈涛, 朱晔涵, 蒋军红, 等. 肺隐球菌病PET/CT误诊肺癌一例并文献复习[J]. 中国血液流变学杂志, 2013, 23(1):76-77.
[13] Beauregard JM, Giraudet AL, Aide N, et al. Evaluation of a new vi-sual uptake scoring scale for 18F-fluorothymidine positron emission tomography in the diagnosis of pulmonary lesions[J]. Nucl Med Commun, 2013, 34(6):521-526.
[14] 华逢春, 管一晖, 张政伟, 等. 11C-胆碱与18F-FDG双时相PET显像在孤立性肺结节鉴别诊断中的应用[J]. 中华核医学杂志, 2006, 26(1):15-18.
[15] Kim KU, Lee K, Park HK, et al. A pulmonary paragonimiasis case mimicking metastatic pulmonary tumor[J]. Korean J Parasitol, 2011, 49(1):69-72.
[16] Cheng W, Li F, Zhuang H, et al. Hepatic paragonimiasis revealed by FDG PET/CT[J]. Clin Nucl Med, 2010, 35(9):726-728.
[17] Wan DQ, Xu AD, Manner CE. False positive for malignancy of a lung nodule on FDG PET/CT scans——a lesion with high FDG up-take but stable in size[J]. Clin Imaging, 2010, 34(5):393-395.
[18] Pinilla I, Herrero Y, Torres MI, et al. Myofibroblatic inflammatory tumor of the lung[J]. Radiologa, 2007, 49(1):53-55.
[19] Chen CK, Jan CI, Tsai JS, et al. Inflammatory myofibroblastic tumor of the lung——a case report[J]. J Cardiothorac Surg, 2010, 5:55.
[20] 郑建国, 屈婉莹, 姚稚明, 等. 18F-FDG PET/CT在孤立性肺结节和肿块中误诊原因分析[J]. 中华核医学杂志, 2007, 27(3):135-138.
[21] 邓智勇, 刘长江, 董燕玉. 18F-FDG-PET/CT融合显像诊断孤立性肺结节的价值[J]. 重庆医学, 2013, 42(4):379-381.
[22] Kubota K, Itoh M, Ozaki K, et al. Advantage of delayed whole-body FDG-PET imaging for tumour detection[J]. Eur J Nucl Med, 2001, 28(6):696-703.
[23] Zhuang H, Pourdehnad M, Lambright ES, et al. Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes[J]. J Nucl Med, 2001, 42(9):1412-1417.
[24] Takashima S, Sone S, Li F, et al. Small solitary pulmonary nodules([25] Tian M, Zhang H, Higuchi T, et al. Oncological diagnosis using 11C-choline-positron emission tomography in comparison with 2-deoxy-2-[18F] fluoro-D-glucose-positron emission tomography[J]. Mol Imag-ing Biol, 2004, 6(3):172-179./html>

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备注/Memo

备注/Memo:
收稿日期:2014-11-08。
通讯作者:韩瑜,Email:963420558@qq.com
更新日期/Last Update: 1900-01-01