[1]陈聪霞,李旭,姚稚明.18F-FDG PET-CT诊断孤立性肺结节良恶性的研究进展[J].国际放射医学核医学杂志,2012,36(6):344-347.[doi:10.3760/cma.j.issn.1673-4114.2012.06.006]
 CHEN Cong-xia,LI Xu,YAO Zhi-ming.The development of 18F-FDG PET-CT in the diagnosis of benign and malignant solitary pulmonary nodules[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):344-347.[doi:10.3760/cma.j.issn.1673-4114.2012.06.006]
点击复制

18F-FDG PET-CT诊断孤立性肺结节良恶性的研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第6期
页码:
344-347
栏目:
PET-CT临床应用及新进展(重点专题)
出版日期:
1900-01-01

文章信息/Info

Title:
The development of 18F-FDG PET-CT in the diagnosis of benign and malignant solitary pulmonary nodules
作者:
陈聪霞 李旭 姚稚明
北京医院核医学科, 北京 100730
Author(s):
CHEN Cong-xia LI Xu YAO Zhi-ming
Department of Nuclear Medicine, Beijing Hospital, Beijing 100730, China
关键词:
硬币病变氟脱氧葡萄糖F18正电子发射断层显像术体层摄影术X线计算机
Keywords:
Coin lesion pulmonaryFluorodeoxyglucose F18Positron-emission tomographyTomography X-ray computer
DOI:
10.3760/cma.j.issn.1673-4114.2012.06.006
摘要:
孤立性肺结节(SPN)的良恶性诊断非常困难,在诊断不明确而手术切除的结节中,约30%为良性。常规影像学技术虽然可以对大部分SPN做出定性诊断,但对一部分SPN仍然诊断困难,且各具有一定的局限性。PET-CT作为一种新的显像技术,能够综合提供SPN的代谢及形态信息,在SPN的良恶性诊断与鉴别诊断中显示出更高的灵敏度及准确率。近期多种新的显像方法的应用更进一步提高了SPN的诊断准确率。
Abstract:
It is very difficult to differentiate correctly between the benign and malignant solitary pulmonary nodules(SPNs). About 30% of the resected indefinite SPNs are benign. Conventional imaging techniques can identify most patients with SPN, but cannot afford a few patients with SPN which have equivocate manifestations, and each has some limitations. PET-CT is a new imaging technique that can offer metabolic and anatomical information of SPN, which results in higher diagnostic sensitivity and accuracy of SPN. Recently various new imaging method is further improved the diagnostic accuracy.

参考文献/References:

[1] Varoli F,Vergani C,Caminiti R,et al.Management of solitary pulmonary nodule.Eur J Cardiothorac Surg,2008,33(3):461-465.
[2] Gould MK,Ghaus SJ,Olsson JK,et al.Timeliness of care in veterans with non-small cell lung cancer.Chest,2008,133(5):1167-1173.
[3] McNulty W,Cox G,Au-Yong L Investigating the solitary pulmonary nodule.BMJ,2012,344:e2759.
[4] 刘玉洪,孙磊,王明钊,等.孤立性肺结节的诊断与治疗策略(附78例报告).山东医药,2006,46(15):58-59.
[5] Gergely I,Neumann C,Reiger F,et al.Lung nodule detection with ultra-low-dose CT in routine follow-up of cancer patients.Rofo,2005,177(8):1077-1083.
[6] Tozaki M,Ichiba N,Fukuda K.Dynamic magnetic resonance imaging of solitary pulmonary nodules:utility of kinetic patterns in differential diagnosis.J Comput Assist Tomogr,2005,29(1):13-19.
[7] 秦子敏.肺孤立性结节的诊断与处理.国际肿瘤学杂志,2007,34(9):686-691.
[8] Romano M,Griffo S,Gentile M,et al.CT guided percutaneous fine needle biopsy of small lung lesions in outpatients.Safely and efficacy of the procedure compared to inpatients.Radiol Med,2004,108(3):275-282.
[9] Gould MK,Maclean CC,Kuschner WG,et al.Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions:a meta-analysis.JAMA,2001,285(7):914-924.
[10] Ruiz-Hernández G,de Juan R,Samanes A,et al.Positron emission tomography using 18-FDG-PET in radiologically indeterminate pulmonary lesions’ An Med Interna,2004,21(1):12-16.
[11] 潘中允,屈婉莹,周诚,等.PET/CT诊断学.北京:人民卫生出版社,2009:433-478.
[12] 张金娥,梁长虹,赵振军,等.CT和正电子发射计算机体层摄影术诊断孤立性肺结节的局限性和协同作用.中华放射学杂志,2005,39(11):1148-1152.
[13] Ding QY,Hua YQ,Zhang GZ,et al.A controlled study of positron-emission-tomography and positron-emission-tomography/computed tomography in differential diagnosis of solitary pulmonary nodules-report of 60 cases.Chin Med J,2005,118(18):1572-1576.
[14] Yi CA,Lee KS,Kim BT,et al.Tissue characterization of solitary pulmonary nodule:comparative study between helical dynamic CT and integrated PET/CT.J Nucl Med,2006,47(3):443-450.
[15] Chang CY,Tzao C,Lee SC,et al.Incremental value of integrated FDG-PET/CT in evaluating indeterminate solitary pulmonary nodule for malignancy.Mol Imaging Biol,2010,12(2):204-209.
[16] Martins Rde C,Almeida SA,Siciliano AA,et al.Value of[18F]-FDG-PET/CT as a predictor of cancer in solitary pulmonary nodule.J Bras Pneumol,2008,34(7):473-480.
[17] 郑建国,屈婉莹,姚稚明,等.18F-FDG PET/CT对不同大小孤立性肺结节的诊断价值.中华核医学杂志,2008,28(3):170-173.
[18] Kim SK,Allen-Auerbach M,Goldin J,et al.Accuracy of PET/CT in characterization of solitary pulmonary Lesions.J Nucl Med,2007,48(2):214-220.
[19] 郑建国,屈婉莹,姚稚明,等.18F-FDG PET/CT在孤立性肺结和肿块中误诊原因分析.中华核医学杂志,2007,27(3):135-138.
[20] Dewan NA,Gupta NC,Redepenning LS,et al.Diagnosis efficacy of PET-FDG imaging in solitary pulmonary nodules:Potential role in evaluation and management.Chest,1993,104(4):997-1002.
[21] 姚树展,韩建奎,刘庆伟,等.良恶性肺孤立性小结节的PET-CT影像学特点分析研究.医学影像学杂志,2005,15(8):669-672.
[22] Langen KJ,Braun U,Rota Kops E,et al.The influence of plasma glucose levels on fluorine-18-fluorodeoxyglucose uptake in bronchial carcinomas.J Nucl Med,1993,34(3):355-359.
[23] 姚稚明,屈婉莹,刘甫庚,等.18F-FDG PET/CT双时相显像对孤立性肺结节的诊断价值.中华核医学杂志,2007,27(1):5-7.
[24] Kim IJ,Kim SJ,Kim YS,et al.Characterization of pulmonary lesiona with low F-18 FDG uptake using double phase F-18 FDG PET/CT:comparison of visual and quantitative analyaes.Neoplasma,2009,56(1):33-39.
[25] Sathekge MM,Maes A,Pottel H,et al.Dual time-point FDG PET/CT for diferentiating benign from malignant solitary pulmonary nodules in a TB endemic area.S Afr Med J,2010,100(9):598-601.
[26] 陈伟华,齐景伟,李淑荣.18F-脱氧葡萄糖PET-CT显像结合高分辨率CT对孤立性肺结节的诊断价值.中国老年学杂志,2009,29(14):1746-1747.
[27] Pan T,Mawlawi O,Nehmeh SA,et al.Attenuation correction of PET images with respiration-averaged CT images in PET/CT.J Nucl Med,2005,46(9):1481-1487.
[28] Werner MK,Parker JA,Kolodny GM,et al.Respiratory gating enhances imaging of pulmonary nodules and measurement of tracer uptake in FDG PET/CT.AJR Am J Roentqenol,2009,193(6):1640-1645.
[29] Tian J,Yang X,Yu L,et al.A multicenter clinical trial on the diagnostic value of duai-tracer PET/CT in pulmonary lesions using 3-deoxy-3-18F-fluorothymidine and 18F-FDG.J Nucl Med,2008,49(2):186-194.
[30] Shibata H,Nomori H,Uno K,et al.11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma:comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness.Ann Nucl Med,2009,23(7):609-616.

相似文献/References:

[1]孙萌萌,付畅,史大鹏,等.不同分期肺腺癌患者大脑静息葡萄糖代谢改变研究[J].国际放射医学核医学杂志,2015,39(6):437.[doi:10.3760/cma.j.issn.1673-4114.2015.06.001]
 Sun Mengmeng,Fu Chang,Shi Dapeng,et al.Preliminary study of metabolic changes in brain glucose of patients with lung adenocarcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):437.[doi:10.3760/cma.j.issn.1673-4114.2015.06.001]
[2]丛英珍,王志军,王大飞,等.肺不典型腺瘤样增生三例[J].国际放射医学核医学杂志,2015,39(6):509.[doi:10.3760/cma.j.issn.1673-4114.2015.06.016]
[3]王振光,韩瑜.肺肉芽肿性炎正电子核素显像机制与影像特征[J].国际放射医学核医学杂志,2015,39(3):264.[doi:10.3760/cma.j.issn.1673-4114.2015.03.017]
 Wang Zhenguang,Han Yu.Mechanism and performance of position radionulide imaging in lung granuloma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):264.[doi:10.3760/cma.j.issn.1673-4114.2015.03.017]
[4]丁其勇,陈建伟,张清波,等.肺部良性结节样病变18F-FDG摄取不均匀性的特点分析[J].国际放射医学核医学杂志,2013,37(3):168.[doi:10.3760/cma.j.issn.1673-4114.2013.03.010]
 DING Qi-yong,CHEN Jian-wei,ZHANG Qing-bo,et al.18F-FDG uptake nonuniform characteristics in pulmonary benign nodules[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(6):168.[doi:10.3760/cma.j.issn.1673-4114.2013.03.010]
[5]米宝明,万卫星,郁春景,等.18F-FDGPET和CT判断肺结核病灶活动性的比较[J].国际放射医学核医学杂志,2012,36(3):151.[doi:10.3760/cma.j.issn.1673-4114.2012.03.007]
 MI Bao-ming,WAN Wei-xing,YU Chun-jing,et al.Comparison between 18F-FDG PET and CT in evaluating the activity of pulmonary tuberculosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):151.[doi:10.3760/cma.j.issn.1673-4114.2012.03.007]
[6]孟钺.68例老年肺结核X线及CT征象分析[J].国际放射医学核医学杂志,2010,34(1):58.[doi:10.3760/cma.j.issn.1673-4114.2010.01.016]
[7]刘振宽.肺炎性假瘤41例X线和CT影像[J].国际放射医学核医学杂志,2007,31(2):128.
 LIU Zhen-kuan.X-ray and CT imaging diagnosis for 41 cases of pulmonary inflammatory pseudotumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(6):128.
[8]王城,王雪梅,王春梅,等.18F-FDGPET-CT双时相显像结合高分辨率CT诊断孤立性肺结节的价值[J].国际放射医学核医学杂志,2011,35(3):154.[doi:10.3760/cma.j.issn.1673-4114.2011.03.006]
 WANG Cheng,WANG Xue-mei,WANG Chun-mei,et al.Dual phase time scan combine high resolution CT to diagnose solitary pulmonary nodule by 18F-FDG PET-CT[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(6):154.[doi:10.3760/cma.j.issn.1673-4114.2011.03.006]
[9]安彩霞,王云生,杨丽娟,等.容积倍增时间在64层螺旋CT诊断孤立性肺结节中的价值[J].国际放射医学核医学杂志,2011,35(4):249.[doi:10.3760/cma.j.issn.1673-4114.2011.04.014]
 AN Cai-xia,WANG Yun-sheng,YANG Li-jiwn,et al.The value of volume doubling time in diagnosis of solitry pulmonary nodules by 64-slice spiral CT[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(6):249.[doi:10.3760/cma.j.issn.1673-4114.2011.04.014]
[10]刘长江,董燕玉.99Tcm-depreotide显像对肺部病灶的鉴别诊断价值[J].国际放射医学核医学杂志,2009,33(2):79.[doi:10.3760/cma.j.issn.1673-4114.2009.02.005]
 LIU Chang-fiang,DONG Yan-yu.The clinical value of 99Tcm-depreotide scintigraphy in differentiating malignant from benign lesions in the lung[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(6):79.[doi:10.3760/cma.j.issn.1673-4114.2009.02.005]

备注/Memo

备注/Memo:
收稿日期:2012-09-09。
基金项目:首都医学发展科研基金(2009-2016)
通讯作者:姚稚明(Email:yao.zhiming@163.com)
更新日期/Last Update: 1900-01-01