[1]刘晓秋,王芹,王德芝,等.放射增敏剂尼可胺对雄性大鼠生殖毒性的研究[J].国际放射医学核医学杂志,2012,36(5):293-296.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.007]
　LIU Xiao-qiu,WANG Qin,WANG De-zhi,et al.The reproductive toxicity of NiKeAn in male rats[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(5):293-296.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.007]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第5期
页码:
293-296
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The reproductive toxicity of NiKeAn in male rats
作者:
刘晓秋;  王芹;  王德芝;  周则卫;  沈秀;  韩英
中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300192
Author(s):
LIU Xiao-qiu;  WANG Qin;  WANG De-zhi;  ZHOU Ze-wei;  SHEN Xiu;  HAN Ying
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
关键词:
生殖毒性; 大鼠; Wistar; 尼可胺
Keywords:
Preconception injuries; Rats; Wistar; NiKeAn
DOI:
10.3760/cnla.j.issn.1673-4114.2012.05.007
摘要:
目的 观察尼可胺对雄性大鼠生殖能力的影响。方法 将100只健康成年雄性Wistar大鼠随机分为4组:空白对照组(0.9%氯化钠注射液)、尼可胺高剂量组(300 mg/kg)、尼克胺中剂量组(200 mg/kg)和尼克胺低剂量组(100 mg/kg).雄性大鼠连续尾静脉注射给药5周后(每日1次),与100只雌性Wistar大鼠随机1:1合笼交配,交配后处死雄性大鼠,检查尼可胺对各剂量组雄性大鼠的交配率、精子数量、精子活率、精子活力、脏器系数的影响及睾丸、附睾的组织病理学变化。结果 200 mg/kg以下剂量对成年雄性大鼠检测的生育指标无明显影响。结论 200 mg/kg以下剂量对成年雄性大鼠的生殖功能无明显毒性作用.
Abstract:
Objective To observe the toxic effects of NiKeAn on the ability of reproduction in male rats.Methods One hundred health adult Wistar rats were randomly divided into 4 groups with 25 in each group.The rats of control groups were given intravenous injections with normal saline and the experimental groups received NiKeAn at doses of 300 mg/kg,200 mg/kg and 100 mg/kg once per day.All rats were injected for 5 weeks then mated and executed.The coefficient of testicle and epididymis,mating rate,sperm,the percentage of motile sperm,and histopathological changes of testicle and epididymis were detected.Results Under doses of 200 mg/kg concentration of NiKeAn used in this study have no significant influence on the aforementioned parameters.Conclusion Under doses of 200 mg/kg,reproductive function of male rats does not obviously impaired by NiKeAn.

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备注/Memo

备注/Memo:
收稿日期:2012-05-06。
基金项目:天津市科技支撑计划重点项目(09ZCKFSH01500)
通讯作者:王芹(Email:wangqin_1005@yahoo.com.cn)
更新日期/Last Update: 1900-01-01