[1]张敏,周莉,张开贤,等.中下段食管癌调强放疗布野方案剂量学比较[J].国际放射医学核医学杂志,2012,36(2):121-123,129.[doi:10.3760/cma.j.issn.1673-4114.2012.02.016]
　ZHANG Min,ZHOU Li,ZHANG Kai-xian,et al.Dosimetric comparison of different schemes for arrange beams in intensity modulated radiation therapy for mid-and distal-esophageal carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):121-123,129.[doi:10.3760/cma.j.issn.1673-4114.2012.02.016]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第2期
页码:
121-123,129
栏目:
临床放射医学
出版日期:
2012-03-25

文章信息/Info

Title:
Dosimetric comparison of different schemes for arrange beams in intensity modulated radiation therapy for mid-and distal-esophageal carcinoma
作者:
张敏1;  周莉2;  张开贤1;  李苓1;  石存3
1. 山东省滕州市中心人民医院肿瘤科, 滕州 277500;
2. 四川大学华西医院肿瘤中心放射物理技术中心, 成都 610041;
3. 山东省滕州市东郭中心卫生院内科, 滕州 277500
Author(s):
ZHANG Min1;  ZHOU Li2;  ZHANG Kai-xian1;  LI Ling1;  SHI Cun3
Department of Cancer, Tengzhou Central Hospital, Tengzhon 277500, China
关键词:
食管肿瘤; 放射治疗计划; 计算机辅助; 放射疗法; 调强适形; 病例对照研究
Keywords:
Esophageal neoplasms; Radiotherapy planning;  computer-assisted; Radiation therapy; intensity-modulated; Case-control studies
DOI:
10.3760/cma.j.issn.1673-4114.2012.02.016
摘要:
目的 分析中下段食管癌放疗中5野调强计划与7野调强计划的差异,寻找布野最佳方案.方法 分别为接受调强放射治疗的12例中下段食管癌患者设计5野调强计划与7野调强计划,计划设计中要求95%的计划靶体积达到处方剂量.在每个病例中,分别比较两种计划的剂量体积直方图统计数据、剂量均匀指数、剂量适形指数.结果 两种方案中,7野调强计划的靶区剂量适形度较好(t=2.681,P<0.05);两种方案的剂量均匀指数、脊髓受照剂量、心脏受照剂量之间的差异无统计学意义;5野调强计划的双肺V5、V10、V15较低(t=-7.938、-12.055和4.859,P均<0.05).结论 在中下段食管癌放疗中,与7野调强计划相比,5野调强计划可以减少肺部的低剂量受照体积,同时提供可以接受的计划靶体积适形度,有助于减少肺部辐射损伤的发生概率,改善患者生存质量,值得在临床工作中推广应用。
Abstract:
Objective To analyze the difference between five-field plan and seven-field plan in intensity modulated radiation therapy for patients with mid-and distal-esophageal carcinoma,and to find out the optimal beam arrangement.Methods Five-field plan and seven-field plan were designed for each of 12 patients with mid-and distal-esophageal carcinoma.95% of planning target volume was required to achieve prescription dose.Dose-volume histograms statistics,dose uniformity,and dose conformity in every patient were compared respectively.Results Superior dose conformity for planning target volume was shown in seven-ficld plan (t=2.681,P<0.05).Difference was not significant between uniformity in seven-field plan and that in five-field plan.Difference was not significant between doses received by organs at risk,such as spinal cord and heart,in seven-field plan and those in five-field plan.V5,V10,V15 of lungs in five-field plan were lower significantly than those in seven-field plan (t=-7.938,-12.055 and -4.859,all P<0.05).Conclusions For patients with thoracic esophageal carcinoma treated by intensity modulate radiation therapy,compared with 7-fielded plan,the volume of lungs with lower dose could be reduced on the premise of acceptable planning target volume coverage by the application of five-plan.Therefore,radiation-induced lung injury occurrence probability would be reduced,and the patient’s quality of life would be improved.Five-field plan would be worth applying in the clinical work.

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备注/Memo

备注/Memo:
收稿日期:2011-12-28。
通讯作者:周莉,Email:c.cdzhou@gmail.com
更新日期/Last Update: 1900-01-01