[1]王宏,刘强,杜丽清,等.DNA修复基因hOGG1的寡核苷酸多态性与癌症遗传易感性的关系[J].国际放射医学核医学杂志,2012,36(2):101-105.[doi:10.3760/cma.j.issn.1673-4114.2012.02.011]
　WANG Hong,LIU Qiang,DU Li-qing,et al.Single nucleotide polymorphism of DNA repair gene hOGG1 and genetic susceptibility of cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):101-105.[doi:10.3760/cma.j.issn.1673-4114.2012.02.011]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第2期
页码:
101-105
栏目:
放射生物学
出版日期:
2012-03-25

文章信息/Info

Title:
Single nucleotide polymorphism of DNA repair gene hOGG1 and genetic susceptibility of cancer
作者:
王宏;  刘强;  杜丽清;  王彦;  付岳;  陈凤华;  樊飞跃
中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津 300192
Author(s):
WANG Hong;  LIU Qiang;  DU Li-qing;  WANG Yan;  FU Yue;  CHEN Feng-hua;  FAN Fei-yue
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
关键词:
人源8-羟基鸟嘌呤DNA糖苷酶基因; 多态性; 单核苷酸; 肿瘤; 疾病遗传易感性; 肿瘤; 辐射性
Keywords:
Human 8-oxoguanine DNA glycosylase gene; Polymorphism;  single nucleotide; Neoplasms; Genetic predisposition to disease; Neoplasms;  radiation-induced
DOI:
10.3760/cma.j.issn.1673-4114.2012.02.011
摘要:
该文从基因结构、生物学功能和基因寡核苷酸多态性与疾病发生等方面探讨人源8-羟基鸟嘌呤DNA糖苷酶(hOGG1)基因在DNA损伤修复中的作用及其基因寡核苷酸多态性与癌症的遗传易感性的关系;综述hOGG1基因与癌症遗传易感性的分子流行病学研究;探讨hOGG1基因寡核苷酸多态性与辐射致癌的关系;指出hOGG1基因作为癌症易感人群诊断和预防标志物的价值。
Abstract:
This article discussed on the relationship between single nucleotide polymorphism of DNA repair gene human 8-oxoguanine DNA glycosylase (hOGG1) and genetic susceptibility of cancer in aspects of gene structure,biological function and relationship with disease:reviewed molecular epidemiology studies of hOGG1 and cancer genetic susceptibility; figured out the diagnosis and prevention value of hOGG1 as a biomarker of cancer susceptible populations.

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备注/Memo

备注/Memo:
收稿日期:2011-11-27。
基金项目:国家自然科学基金(30800281,31170804)天津市自然科学基金(07JCYBJC09200)教育部高等学校博士学科点专项科研基金(200800231051)
通讯作者:樊飞跃,Email:faithfan@yahoo.com
更新日期/Last Update: 1900-01-01