[1]姚小芹,王辉.BRAPV600E基因突变在甲状腺癌中的临床应用研究进展[J].国际放射医学核医学杂志,2012,36(2):84-87.[doi:10.3760/cma.j.issn.1673-4114.2012.02.006]
 YAO Xiao-qin,WANG Hui.Advances in clinical utility of BRAFV600E mutation in thyroid cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):84-87.[doi:10.3760/cma.j.issn.1673-4114.2012.02.006]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第2期
页码:
84-87
栏目:
临床核医学
出版日期:
2012-03-25

文章信息/Info

Title:
Advances in clinical utility of BRAFV600E mutation in thyroid cancer
作者:
姚小芹 王辉
上海交通大学医学院附属新华医院核医学科, 上海 200092
Author(s):
YAO Xiao-qin WANG Hui
Department of Nrnikar Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
关键词:
原癌基因蛋白质B-raf甲状腺肿瘤点突变诊断
Keywords:
Proto-oncogene protein B-rafThyroid neoplasmsPoint mutationDiagnosis
DOI:
10.3760/cma.j.issn.1673-4114.2012.02.006
摘要:
B型RAF基因(BRAF)编码蛋白质的第600位密码子对应的缬氨酸被谷氨酸替代(BRAPV600E突变)是甲状腺乳头状癌中最常见的基因突变。很多研究表明,该突变与甲状腺乳头状癌的发生、发展和转移密切相关。该文综合阐明BRAPV600E突变在甲状腺乳头状癌中的术前诊断、预后判断和抑制剂治疗等方面的临床应用,以便更好地指导临床决策。
Abstract:
Valine(V) being substituted for by glutamate(E) at codon 600 in B type RAF gene (BRAFV600E mutation) is the most common genetic mutation in papillary thyroid cancer. There have been many researches shown a strong association between BRAFV600E mutation and the occurrence, progression and metastasis of papillary thyroid cancer. This article illustrates its clinical utility on the preoperative diagnosis, prognosis evaluation and inhibitor treatment of papillary thyroid cancer, so as to instruct the clinical management better.

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备注/Memo

备注/Memo:
收稿日期:2012-01-22。
通讯作者:王辉,Email:wanghuishanghai@hotmail.com
更新日期/Last Update: 1900-01-01