[1]周敏,林美福,陈文新.18F-FDG PET结合高分辨率CT在细支气管肺泡癌诊断中的价值[J].国际放射医学核医学杂志,2011,35(6):347-350.[doi:10.3760,cma.j.issn.1673-4114.2011.06.006]
　ZHOU Mirg,LIN Mei-fu,CHEN Wen-xin.The application of 18F-FDG PET and HRCT in the diagnosis of bronchial alveolar carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(6):347-350.[doi:10.3760,cma.j.issn.1673-4114.2011.06.006]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第6期
页码:
347-350
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The application of 18F-FDG PET and HRCT in the diagnosis of bronchial alveolar carcinoma
作者:
周敏1;  林美福2;  陈文新2
1. 福建省莆田市第一医院核医学科, 福建 351100;
2. 福建省立医院核医学科, 福州 350001
Author(s):
ZHOU Mirg1;  LIN Mei-fu2;  CHEN Wen-xin2
Department of Nucle’ar Medicine, the First Hospital of Fujian Putian, Putian 351100, China
关键词:
腺癌; 细支气管肺泡; 氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机
Keywords:
Adenocarcinoma; Bronchiolo-AlveolaI; Fluomdeoxyglucose F18; Positron-emission tomography; Tomography; X-ray computed
DOI:
10.3760,cma.j.issn.1673-4114.2011.06.006
摘要:
目的 探讨18F-FDG PET及高分辨率CT(HRCT)在细支气管肺泡癌(BAC)诊断及鉴别诊断中的价值。方法 回顾性分析具有完整临床资料的患者18例,其中病理检查确诊17例为BAC,1例经抗炎治疗后病灶消失。测量病灶标准化摄取值(suv),分析病灶的影像学征象,比较单纯18F-FDG PET、HRCT及二者联合诊断的效能。结果 ①单发结节组5例,SUV为1.5~3.5,其中4例同时行HRCT,见毛刺征4例、分叶3例、胸膜凹陷征3例、血管集束征3例、空泡征2例、毛玻璃征1例。②局限性实变组6例,SUV为1.6~2.3,其中5例同时行HRCT,见毛玻璃征5例、胸膜凹陷征3例、空泡征2例、支气管充气征2例、血管集束征1例。③混合组4例,SUV为4.5~10.0,4例均同时行HRCT,见毛玻璃征2例、空泡征1例、胸膜凹陷征2例、支气管充气征3例。④肿块组1例,SUV为5.6,见分叶、空洞、胸膜凹陷征及血管集束征。⑤多发结节组1例,SUV为4.6,见分叶、细毛刺征。⑥假阳性组1例,病灶大小为2.1 cm×2.3 cm,SUV为1.2。结论单发结节组、局限性实变组的病灶对18F-FDG摄取较低,易误诊,PET代谢显像结合HRCT有利于提高BAC诊断及鉴别诊断的准确率。
Abstract:
Objective To investigate the features and diagnostic values of 18F-FDG PET and high resolution CT(HRCT) in patients with bronchial alveolar carcinoma (BAC).Methods Seventeen cases with pathologically confirmed BAC and 1 case confirmed inflammation were studied retrospectively.The standardized uptake value (SUV) of the lesions were detected and 18F-FDG uptake characteristics were studied.The diagnostic values of 18F-FDG PET.HRCT and 18F-FDG PET combined with HRCT were analyzed.Results ① In the group of solitary nodule (n=5),SUV of lesions were 1.5-3.5.HRCT (4/5) demonstrated spiculated (4/4),lobulated (3/4),pleural indentation (3/4),vascular convergence (3/4),vacuole sign (2/4) and ground-glass sign (1/4).② In the group oflobar consolidation (n=6),SUV of lesions were 1.6-2.3. HRCT (5/6) demonstrated ground-glass (5/5),pleural indentation (3/5),vacuole sign (2/5),air bronchogram sign (2/5) and blood vessel convergency (1/5).③In the group of mixed shadow (n=4),SUV of lesions were 4.5-10.0.Ground-glass sign,vacuole sign,pleural tag and air bronchogram sign were seen in 2,1,2 and 3 cases respectively.④ There was 1 case in the group of mass lesion.The SUV of lesion was 5.6,and HRCT demonstrated lobulated,cavity,pleural indentation and blood vessel convergency.⑤ There was 1 case in the multi-nodular group,SUV was 4.6,lobulation and spiculation sign were found.⑥SUV was 1.2 in the false positive case,with the lesion size of 2.1 cm×2.3 cm.Conclusions Low uptake of 18F-FDG in solitary nodule and lobar consolidation groups might cause false negative in the diagnosis of BAC.To improve the diagnosis accuracy and to decrease misdiagnosis rate of BAC.combination of HRCT with 18F-FDG PET should be carfled out.

参考文献/References:

[1] Raz DJ,He B,Rosell R,et al.Current concepts in bronchioloalveo-1ar carcinoma biology.Clin Cancer Res,2006,12(12):3698-3704.
[2] Kim HY,Shim YM,Lee KS,et al.Persistent pulmonary nodular ground-glass opacity at thin-section CT:histopathologic compar-isons.Radiology,2007,245(1):267-275.
[3] Wang T,Sun YE,Zhou NK,et al.Fluorine一18 fluorodeoxyglucose uptake in patients with primary lung cancer.Chin J Surg,2002,40(6):437-440.
[4] 邓宇,曾庆思,伍筱梅,等.细支气管肺泡癌影像学特征的深入性探讨.放射学实践,2005,20(2):128-131.

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备注/Memo

备注/Memo:
收稿日期:2011-09-28。
通讯作者:周敏(Email:13559398955@139.com)
更新日期/Last Update: 1900-01-01