[1]武明芬,王荣先,尹鹏.18F标记的非天然氨基酸PET显像剂[J].国际放射医学核医学杂志,2008,32(4):202-205.
 WU Ming-fen,WA NG Rong-xian,YIN Peng.PET imaging agent of 18F lablled non-natrual animo acid[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(4):202-205.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第4期
页码:
202-205
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
PET imaging agent of 18F lablled non-natrual animo acid
作者:
武明芬 王荣先 尹鹏
300192 天津, 中国医学科学院放射医学研究所药学研究室
Author(s):
WU Ming-fen WA NG Rong-xian YIN Peng
Department of Pharmaceuticoi, Institute of Radiation Medwine, Chinese Academy of Medwd Science, Tianjin 300192, China
关键词:
氟放射性同位索同位素标记酪氨酸苯丙氨酸脯氨酸甲硫氨酸
Keywords:
Fluorine radioisotopeIsotope labelingTymsinePhenylalaninePralineMethionine
摘要:
随着PET、PET-CT技术的迅速发展,18F标记的放射性氨基酸药物在临床上的应用越来越广泛。由于18F具有优越的物理特性、相对长的半衰期(110 min)、其类氢特性不致于引起标记分子的空问结构发生明显改变,因此18F是用于PET的放射性核素的最佳选择。而天然氨基酸存在易代谢及代谢复杂的特点,所以近来人们对非天然氨基酸的研究逐渐增多,如酪氨酸衍生物、苯丙氨酸衍生物、脯氨酸衍生物、甲硫氨酸衍生物等。综述了近年来18F标记的非天然氨基酸及其衍生物的研究进展。
Abstract:
Along with the rapid development of PET and PET-CT technologies,the application of 18F-labelled radiopharmaeeuticals is more and more widespread in clinic.18F has predominant physical features with long half-life (110min).Also,the chemical nature of 18F is similar to that of hydrogen,it can’t change the labelled molecular’s character obviously.Therefore,the 18F is the best choice of radionuclide used in PET. However,natural animo acid has the character of metabolizing easily and complexly,the studies in non-natmal animo acid have increased gradually such as tyrosine derivatives,phenylalanine derivatives,praline derivatives,methionine derivatives,and so on.The article summarizes the 18F-labelled non.natural amino acids and their derivatives studied in recent years.

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备注/Memo

备注/Memo:
收稿日期:2008-04-02。
通讯作者:王荣先,E-mail:wangrx408@sina.com
更新日期/Last Update: 1900-01-01