[1]林伟,邬恒夫,武兆忠,等.99mTc-HL91显像在缺血陛脑血管病中脑乏氧组织的应用研究[J].国际放射医学核医学杂志,2008,32(3):165-166,174.
　LIN Wei,WU Heng-fu,WU Zhao-zhong,et al.Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HLgl imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(3):165-166,174.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第3期
页码:
165-166,174
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HLgl imaging
作者:
林伟;  邬恒夫;  武兆忠;  邓力平;  刘影;  吴长伟;  丁志辉
510260 广州, 广州医学院第二附属医院核医学科
Author(s):
LIN Wei;  WU Heng-fu;  WU Zhao-zhong;  DENG Li-ping;  LIU Ying;  WU Chang-wei;  DING Zhi-hui
Department of Nuclear Medicine, The Second Affiliated Hospital, Guangzhou Medical College, Guangzhou 510260, China
关键词:
脑梗死; 细胞低氧; 缺血缺氧; 脑; 体层摄影术; 发射型计算机; 单光子
Keywords:
Brain infarction; Cell hypoxia; Hypoxia-ischemia; brain; Tomography; emissioncomputed; single
摘要:
目的 探讨99mTc-4,9-二氮。3,3,10,10-四甲基十二烷-2,11-二酮肟(99mTc-HL91)在缺血性脑血管病中脑乏氧组织的临床应用价值。方法 对9例对照组和17例急性脑梗死患者于起病7 d内进行脑乏氧显像,同时进行了CT或MRI检查。其中2例分别于第一次显像阳性后9 d和12 d进行第二次乏氧显像。结果 对照组未见脑实质有明显核素浓聚,左侧,右侧比值为0.98±0.04.17例急性脑梗死患者中,乏氧显像阳性11例,阳性率64.7%,其患侧/健侧比值为1.54±0.55,与对照组比较有显著性差异(t=3.081,P<0.05)。结论 99mTc-HL91显像可以区分乏氧与坏死的脑组织,对指导治疗、评价疗效有一定的临床意义。
Abstract:
Objective To investigate the detection of brain hypoxic tissue in patients with ischemic cerebrovaseular of brain using 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(99mTc-HL91)maging.Methods Nine controls and 17 patients with acute infarction of brain underwent 99mTc-HL91 imaging.Results The ratios of left/fight in controls is 0.98±0.04.The ratios of L/N in patients is 1.54±0.55.Conclusion 99mTc-HL91 imaging could detect brain hypoxie tissue after ischemic cerebrovascular of brain.

参考文献/References:

[1] Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction[J]. Lancet, 1991, 337(8756):1521-1526.
[2] Heiss WD. Ischemic penumbra:evidence from functional imaging in man[J]. J Cereb Blood Flow Metab, 2000, 20(9):1276-1293.
[3] 刘生, 王艺东, 蒋宁一, 等.99Tc m-HL91 SPECT显像检测急性脑梗死乏氧脑组织的研究[J].中华核医学杂志,2004,24(4):236-237.
[4] 冯珏, 冯亚青, 边艳珠, 等.新型乏氧显像剂99Tc m-HL91在缺血性脑血管病中的试验研究[J].中国医学影像技术,2003,19(2):164-166.

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备注/Memo

备注/Memo:
收稿日期:2007-08-12。
通讯作者:林伟(E-mail:gzlinwei@tom.com)
更新日期/Last Update: 1900-01-01