[1]蒋宁一,熊玥.放射免疫导向治疗真菌感染灶的研究[J].国际放射医学核医学杂志,2008,32(3):137-139.
 JIANG Ning-yi,XIONG Yue.Research about the radioimmunotherapy of fungal infection[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(3):137-139.
点击复制

放射免疫导向治疗真菌感染灶的研究(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第3期
页码:
137-139
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Research about the radioimmunotherapy of fungal infection
作者:
蒋宁一 熊玥
510120 广州, 中山大学附属第二医院核医学科
Author(s):
JIANG Ning-yi XIONG Yue
Department of Nuclear Medicine, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China
关键词:
放射免疫疗法真菌病抗体真菌
Keywords:
RadioimmunotherapyMycosesAntibodiesfungalBhenimn
摘要:
由于广谱抗生素、皮质类同醇和免疫抑制剂的广泛应用,可能会导致机体免疫力低下,使致病真菌感染的机会增大,寻找更好的抗真菌疗法是医学研究方向之一。电离辐射可以快速有效的杀死微生物,也可以抗真菌。研究表明,通过特异性抗体标记的靶向放射免疫治疗方法将可能成为抗真菌的一种有效治疗途径。
Abstract:
The wide use of the broad-spectrum antibiotics,corticosteroids and immunosuppressant may lead to lower immunity which can increases the chance of fungi infection.Searching a better antifungal therapy is one of the direction of medical research.Ionizing radiation can quickly and effectively kill the microorganisms,and also can be the antifungal.The research suggests that the method of targeting radioimmunotherapy labeled specific antibody may become an effective antifungal treatment channels.

参考文献/References:

[1] Beck-Sagué C, Jarvis WR. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System[J]. J Infect Dis,1993, 167(5):1247-1251.
[2] Wisplinghoff H, Seifert H, Tallent SM, et al. Nosocomial bloodstream infections in pediatric patients in United States hospitals:epidemiology, clinical features and susceptibilities[J]. Pediatr Infect Dis J, 2003, 22(8):686-691
[3] 吴安华,任南,文细毛,等.全国医院感染监控网1998-1999年监测资料分析[J].中华医院感染学杂志,2000,10(6):401-403.
[4] Loeffler J, Stevens DA. Antifungal drug resistance[J]. Clin Infect Dis,2003, 36(Suppl 1):S31-S41.
[5] Klein SA, Hermann S, Dietrich JW, et al. Transplantation related toxicity and acute intestinal graft-versus-host disease after conditioning regimens intensified with Rhenium 188-labeled anti-CD66 monoclonal antibodies[J]. Blood, 2002, 99(6):2270-2271.
[6] Dadachova E, Bryan RA, Apostolidis C, et al. Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection[J]. J Infect Dis, 2006, 193(10):1427-1436.
[7] Dadachova E, Howell RW, Bryan RA, et al. Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioirmnunotherapy with alpha-and beta-emitting radioisotopes[J]. J Nucl Med, 2004, 45(2):313-320.
[8] 杨斌,何杨,张玮,等. 99Tc m-抗人粒细胞单克隆抗体对兔炎症的放射免疫显像[J].中华核医学杂志,2002,22(4):228-230.
[9] Shokeen M, Fettig NM, Rossin R. Synthesis, in vitro and in vivo evaluation of radiolabeled nanoparticles[J]. Q J Nucl Med Mol Imaging, 2008, 52(3):267-277.
[10] Rosas AL, Nosanchuk JD, Casadevall A. Passive Immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans Infection[J]. Infect Immun, 2001, 69(5):3410-3412.
[11] Dadachova E, Patel MC, Toussi S, et al. Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins[J]. PloS Med, 2006, 3(11):e427.
[12] Rodrigues ML, Travassos LR, Miranda KR, et al. Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth[J]. Infect Immun, 2000, 68(12):7049-7060.
[13] Casadevall A, Cleare W, Feldmesser M, et al. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies[J]. Antimicrob Agents Chemother, 1998, 42(6):1437-1446.
[14] Dadachova E, Casadenall A. Antibodies as delivery vehicles for radioirmnunotherapy of infectious diseases[J]. Expert Opin Drug Deliv, 2005, 2(6):1075-1084.
[15] Dadachova E, Nakouzi A, Bryan RA, et al. Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection[J]. Proc Natl Acad Sci USA, 2003, 100(19):10942-10947.

相似文献/References:

[1]郭艾楠,魏玲格,傅鹏.131I-肿瘤细胞核人鼠嵌合单克隆抗体治疗实体瘤的研究进展[J].国际放射医学核医学杂志,2013,37(2):120.[doi:10.3760/cma.j.issn.1673-4114.2013.02.015]
 GUO Ai-nan,WEI Ling-ge,FU Peng.Advances on the treatment of solid tumor by 131I labeled mouse-human chimeric tumor necrosis therapy monoclanal antibody[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):120.[doi:10.3760/cma.j.issn.1673-4114.2013.02.015]
[2]姚红霞,张金山.微波消融和131I-肿瘤细胞核人鼠嵌合单克隆抗体联合治疗肺癌[J].国际放射医学核医学杂志,2012,36(5):264.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.002]
 YAO Hong-xia,ZHA NG Jin-shan.Combination of microwave ablation and 131I labeled tumor necrosis therapy chimeric antibody in the treatment of lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):264.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.002]
[3]蔡秋琼,杜明华.131Ⅰ-rituximab治疗B细胞非霍奇金淋巴瘤[J].国际放射医学核医学杂志,2008,32(2):72.
 CAI Qiu-qiong,DU Ming-hua.131Ⅰ-rituximab therapy of B cell non-Hodgkin lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(3):72.
[4]冯春玲.放射免疫治疗中载体的研究进展[J].国际放射医学核医学杂志,2007,31(2):77.
 FENG Chun-ling.Research advances in carrier of radioimmunotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):77.
[5]魏莉,罗荣城.放射性核素标记抗CD20单克隆抗体治疗B细胞淋巴瘤的研究进展[J].国际放射医学核医学杂志,2006,30(3):153.
 WEI Li,LUO Rong-cheng.Advances in research of radioactive nuclide labeled anti-CD20 monoclonal antibody in B cell lymphomas[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):153.
[6]于晓明,樊飞跃.肿瘤放射免疫疗法研究进展[J].国际放射医学核医学杂志,2006,30(2):80.
 YU Xiao-ming,FAN Fei-yue.Recent developments in radioimmunotherapy of tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):80.

备注/Memo

备注/Memo:
收稿日期:2008-01-03。
通讯作者:蒋宁一(E-mail:ningyij@163.net)
更新日期/Last Update: 1900-01-01