[1]郭阳.红细胞生成素及其受体与肿瘤组织乏氧的关系及对治疗的影响[J].国际放射医学核医学杂志,2007,31(5):306-308.
 GUO Yang.Erythropoietin and erythropoietin receptor: relationship to tumor hypoxia and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(5):306-308.
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红细胞生成素及其受体与肿瘤组织乏氧的关系及对治疗的影响(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第5期
页码:
306-308
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Erythropoietin and erythropoietin receptor: relationship to tumor hypoxia and treatment
作者:
郭阳
300060 天津, 天津市环湖医院放射治疗科
Author(s):
GUO Yang
Department of Radiotheropy, Huanhu Hospital, Tianjin 300060, China
关键词:
红细胞生成素受体红细胞生成素细胞低氧
Keywords:
ErythropnietinReceptorerythropoietinCell hyoxia
分类号:
Q513.+2
摘要:
红细胞生成素及其受体的表达与组织乏氧关系密切.在各种实体肿瘤组织内,有大量的红细胞生成素及其受体的表达,其表达与肿瘤细胞对放射治疗和化学药物治疗抗性有关,并增加肿瘤的局部侵袭能力和转移能力,临床上,实体肿瘤患者中约有一半在肿瘤的发展和治疗过程中会出现各种程度的贫血,在贫血的肿瘤患者中使用红细胞生成素的问题还有待进一步研究.
Abstract:
The expression of erythropoietin and its receptor is very close related with the hypoxia status in tumor tissues. There are plenty of erythropoietin and erythropoietin receptor in the solid tumors. They are correlative with the resistance to the radiotherapy and chemotherapy. They also promote the invasive and migration. In clinical, there are more than an half of patients with tumor suffering from various extent of anaemia during the process of developing and treating the tumors, It is need to further investigate the use of erythropoietin in tumor patients.

参考文献/References:

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3 Arcasoy MO, Amin K, Volhner RT, et al. Erythropoietin and erythropoietin receptor expression in human prostate cancer. Mod Pathol, 2005, 18(3):421-430.
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5 Acs G. Zhang PJ, Rebbeck TR, et al. hnmunohistochemieal expression of erythropoietin and erythropoietin receptor in breast carcinoma. Cancer, 2002, 95(5):969-981.
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8 Batra S, Perehnan N, Luck LR, et al. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Lab Invest, 2003, 83(10):1477-1487.
9 Dagnon K, Pacary E, Commo F, et al. Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas. Clin Cancer Res, 2005, 11(3):993-999.
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备注/Memo

备注/Memo:
收稿日期:2007-03-19。
更新日期/Last Update: 1900-01-01