[1]许长德,陈绍亮,石洪成,等.18F-氟脱氧葡萄糖符合线路诊断心肌梗死后的心肌活力[J].国际放射医学核医学杂志,2007,31(4):235-237.
　XU Chang-de,CHEN Shao-liang,SHI Hong-cheng,et al.18F-fluorodeoxyglucose coincidence imaging diagnosis the myocardial viability after myocardial infarct[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):235-237.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第4期
页码:
235-237
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
18F-fluorodeoxyglucose coincidence imaging diagnosis the myocardial viability after myocardial infarct
作者:
许长德1;  陈绍亮2;  石洪成2;  姚之丰2
1. 200240 上海, 复旦大学附属上海市第五人民医院核医学科;
2. 200233 上海, 复旦大学附属中山医院核医学科
Author(s):
XU Chang-de1;  CHEN Shao-liang2;  SHI Hong-cheng2;  YAO Zhi-feng2
1. Department of Nuclear Medicine, Fifth Hospital, Fudan University, Shanghai 200240, China;
2. Depnrtmeru of Nuclear medicine Zhongshan Hospital Fudan University, Shanghai 200233, China
关键词:
心肌; 氟脱氧葡萄糖18F; 99m锝甲氧基异丁基异腈; 体层摄影术; 发射型计算机; 单光子
Keywords:
Myocardium; Fluorodeoxyglucose18F; 99mTc-sestamibi; Tomography; emissioncomputed;  single-photon
分类号:
R817.4
摘要:
目的 利用18F-氟脱氧葡萄糖(18F-FDG)符合线路空腹/糖负荷代谢显像和99mTc-甲氧基异丁基异腈(99mTc-MIBI)来判断心肌梗死后心肌的活力。方法 24例心肌梗死患者进行血管造影、99mTc-MIBI负荷和(或)静息血流灌注检查、18F-FDG符合线路心肌代谢显像(空腹-葡萄糖负荷显像一日法)。结果 99mTc-MIBI灌注显像发现的27个缺血节段在空腹和糖负荷均有18F-FDG的摄取,心肌存活;22个缺血节段在空腹和糖负荷显像后没有18F-FDG的摄取,心肌没有活力。空腹状态心肌对18F-FDG摄取较少,有活力的心肌缺血节段显示特别清晰,图像质量较差;葡萄糖负荷后活力心肌摄取18F-FDG,图像质量有明显改善。结论 空腹和糖负荷都可判断心肌活力,空腹显像时图像的质量稍差,糖负荷能够提高图像质量。
Abstract:
Objective To evaluate the value of(18F-fluorodeoxyglucose, 18F-FDG)coincidence imaging and(99mTc-sestamibi, 99mTc-MIBI)myocardial perfusion imaging diagnosis the myocardial viability after myocardial infarct. Methods 24 cases myocardial infarcts patients undertaking angiography, 99mTc-MIBI stress and rest myocardial perfusion imaging, 18F-FDG coincidence metabolism imaging(fasting-glucose stress one day imaging) with single phone emission computer tomography. Results 27 out of 49 99mTc-MIBI reduced myocardial perfusion myocardial segments mismatch fasting and glucose stress 18F-FDG uptake suggesting the viable myocardial. 22 segments with reduced myocardial perfusion match fasting and glucose stress 18F-FDG uptake suggesting no viable myocardial. Fasting imaging viable myocardial can uptake less 18F-FDG but image well, glucose stress imaging viable myocardial can uptake more 18F-FDG and improved the image quality. Conclusions Fasting and glucose stress can show myocardial viability, imaging quality was less well in fasting and improved in glucose stress.

参考文献/References:

1 Liu XJ,Wang XB,Gao RL,et al. Clinical evaluation of 99mTc-MIBI SPECT in the assessment of coronary artery disease.Nucl Med Commun,1992,13(10):776-779.
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3 De Sutter J,De Winter F,Van WC,et al. Cardiac fluorine-18 fluorodeoxyglucose imaging using a dual-head gamma camera with coincidence detection:a clinical pilot study.Eur J Nucl Med,2000,27(6):676-685.
4 Dilsizian V,Acharach SL,Khin MM,et al. Flurie-18-deoxyglucose SPECT and coincidence imaging for myocardial viability:Clinical and technologic issues.J Nucl Cardiol,2001,8(1):75-88.
5 Berry JJ,B akerjA,Pieper KS,et al. The effect of metabolic mieleu on cardiac PET imaging using flurine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.J Nucl Med,1991,32(8):1518-1525.
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备注/Memo

备注/Memo:
收稿日期:2007-01-03。
通讯作者:许长德(E-mail:xcdfive@yahoo.com.cn)
更新日期/Last Update: 1900-01-01