[1]刘义明,揭育丽.充血性心力衰竭患者肾上腺髓质素与内皮素、血管紧张素Ⅱ结果比较[J].国际放射医学核医学杂志,2007,31(2):96-97,101.
　LIU Yi-ming,JIE Yu-li.A comparision between adrenomedullin, endothelin and angiotensin Ⅱ in patients with congestive heart failure[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):96-97,101.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
96-97,101
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
A comparision between adrenomedullin, endothelin and angiotensin Ⅱ in patients with congestive heart failure
作者:
刘义明1;  揭育丽2
1. 524003 湛江, 湛江第二人民医院检验科;
2. 湛江 524003, 广东医学院附属医院核医学科
Author(s):
LIU Yi-ming1;  JIE Yu-li2
1. Department of Labouratory, Zhan Jiang Second Hospital, Zhanjian 524003, China;
2. Department of Nuclear Medicine, Guangdong Medical College of Appertain Hospital, Guangdong 524003, China
关键词:
心力衰竭; 充血性; 肾上腺髓质素; 内皮素; 血管紧张素Ⅱ
Keywords:
Hear failure;  congestive; Adrenomedullin; Endothelin; Angiotensin II
分类号:
R446.11+2
摘要:
目的 研究充血性心力衰竭(CHF)患者血浆肾上腺髓质素(AM)含量变化及其与血浆内皮素(ET)、血管紧张素Ⅱ(AngⅡ)的关系。方法 用放射免疫法测定95例CHF患者(CHF组)和50例正常人(正常对照组)的血浆AM、ET和AngⅡ含量,同时用彩色超声心动图测定56例CHF患者的左心室射血分数(LVEF)。结果 CHF患者血浆AM高于正常对照组;CHF患者血浆AM、ET、AngⅡ升高程度与心力衰竭严重程度正相关;CHF患者血浆AM与ET、AM与AngⅡ均呈显著正相关;血浆AM与LVEF呈显著负相关(r=-0.6258,P<0.001),与心脏横径/胸廓最大内径呈显著正相关(r=0.6037,P<0.001)。结论 AM参与了CHF的病理生理过程,血浆AM升高可能与血浆ET和AngⅡ升高有关。
Abstract:
Objective To observe the changes of plasma adrenomedu (AM), endothelin (ET) and angioteusin Ⅱ (Ang Ⅱ) in patients with congestive heart failure(CHF). Methods Plasma AM, ET and Ang Ⅱ levels were determined by radioimmuncassay in 95 patients with CHF and 50 healthy control subjects. In 95 patients with CHF, the left ventricular ejection fraction (LVEF) of 56 patients was measured by echocardiography. Results The plasma AM levels were significantly higher in patients with CHF than that in control subjects. The increase of plasma AM, ET and Ang Ⅱ was parallel with the severity of CHF. There was a significant correlation between plasma levels of AM and ET (r=0.7218, P<0.01) and Ang Ⅱ (r=-0.6566, P<0.001). LVEF inversely correlated(r=-0.6258, P<0.001) with plasma AM levels and significantly positive correlated between the plains AM levels and the cardiothoracic ration(r=-0.6037, P<0.05) in patients with CHF. Conclusions These results suggest that AM might play a certain role in the pathophysiology of CHF. The elevated plasma ET and Ang Ⅱ may be responsible for the rise of plasma AM levels in patients with CHF.

参考文献/References:

1 Washimiae H, Asad a Y, Kitamure K, et al. lmmunohistochemical identification of adrenomedullin in human, rat and porcine tissure.Histochem Cell Biol, 1995, 103(4):251.
2 Satoh F, Tekehashi K, Murakami O, et al. lmmunocytocbemicailocaiization of adrenomedullin-like immunoreactivity in the humanmus and the adrenal gland. Neurosci Lett, 1996, 203(3):207.
3 吴琪,孙宏方.血浆内皮素和血管紧张素Ⅱ含量与心力衰竭程度的关系.心血管康复医学杂志,2005,14(5):448-449.
4 吕汉文,叶彩丽,龚先明.充血性心力衰竭治疗前后内皮素,肿瘤坏死因子和血管紧张素转化酶含量比较.中国现代医学杂志,2001,11(1):17-18. 1
5 张伟强,姜丽萍,刘长山.依那普利治疗充血性心力衰竭及对内皮素、肾素-血管紧张素系统的影响.潍坊医学院学报,2003,25(2):121-123.

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备注/Memo

备注/Memo:
收稿日期:2006-07-08。
通讯作者:刘义明(E-mail:liu6433@126.com)
更新日期/Last Update: 1900-01-01