[1]陈冀莹.宫颈癌基因治疗联合放射治疗的研究进展[J].国际放射医学核医学杂志,2006,30(6):365-368.
 CHEN Ji-ying.Progress of cervical cancer genetic-radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(6):365-368.
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宫颈癌基因治疗联合放射治疗的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第6期
页码:
365-368
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress of cervical cancer genetic-radiotherapy
作者:
陈冀莹
014010 包头, 包钢第三职工医院妇产科
Author(s):
CHEN Ji-ying
Department of Gynecology, Bao Gang No. 3 Hospital, Baotou 014010, China
关键词:
宫颈肿瘤基因疗法放射疗法
Keywords:
Cervixl neoplasmsGene therapyRauiotherapy
分类号:
R730.58
摘要:
目前宫颈癌基因治疗尚存在许多问题,距临床应用还有相当的距离,但是在传统的放疗、化疗和手术治疗的基础上,放射治疗与基因治疗的有机结合在宫颈癌治疗中却显示出可喜的前景。本文探讨了宫颈癌基因治疗联合放射治疗的应用前景。
Abstract:
Although cervical cancer gene therapy has a distance to clinical use due to some problems, the combinating of irradiation and gene therapy holds much promise in cancer therapy based on the traditional radiotherapy, chemotherapy and surgery. This revivew focuses on the group of radiogenic therapy that are either.

参考文献/References:

1 KeallP J, Lammering G, LinP S, et al. Tumor control probability predictions forgenetic radiotherapy. Int J Radiat Oncol Biol Phys,2003, 57(1):255-263.
2 De Marco F, Hallez S, Bmlet JM, et al. DNA vaccines against HPV-16 E7-expressing tumour cells. Anticancer Res, 2003, 23(2B):1449-1454.
3 Furumoto H, Irahara M. Human papillomavirus(HPV) and cervical cancer. Med Invest, 2002, 49(3-4):124-133.
4 Rosales C, Valadez-Graham V, Arrellin G, et al. MVA E2 a recombinant vaccinia containing the papilloma virus E2 protein promotes tumor regression by stimulating macrophage antibody-dependent cytotoxicity. Cancer Immunol Immunother, 2000, 49(7):347-360.
5 Garcia-Hernandez E, Gonzalez-Sanchez JL, Andrade-Manzano A, et al. Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine. Cancer Gene Ther, 2006, 13(6):592-597.
6 Green KL, Southgate TD, Mulryan K, et al. Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Hum Gene Ther, 2006, 17(2):147-157.
7 Bruning A, Runnebanm IB. CAR is a cell-cell adhesion proteinin human cancer cell sand is expressionally modulated by dexamethasone, TNFalpha, and TGFbeta. Gene Ther, 2003, 10(3):198-205.
8 Street SE, Cretney E, Smyth MJ. Perfofin and interferon-γ activities independently control tumor initiation, growth, and metastasis.Blood, 2001, 97(1):192-197.
9 Suk K, Kim YH, Chang I, et al. IFN-alpha sensitizes ME-180 human cervical cancer cells to TNF-alpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation. FEBS Lett, 2001,495(1-2):66.
10 Sethi N, Palefsky J. Treatment of human papillomavirus (HPV) type16-infected cells using herpes simplex virus type 1 thymidine kinase mediated gene therapy trans-criptionally regulated by the HPV E2 protein. Hum Gene Ther, 2003, 14(1):45-57.
11 Bilsland AE, Anderson C J, Fletcher-Monaghan A J, et al. Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.Oncogene, 2003, 22(3):370-380.
12 Lim HY, Ahn M, Chung HC. Tumor-specific gene therapy for uterine cervical cancer using MN/CA9-directed replication-competent adenovirus. Cancer Gene Ther, 2004, 11(8):532-538.
13 Choo CK, Ling MT, Suen CK, et al. Retrovirus mediated delivery of HPV16 E7 antisense RNA inhibited tumorigenicity of CaSki cells. Gynecol Oncol, 2000, 78(3):293-301.
14 Ho CW, Poo H, Cho YS, et al. HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing. Exp Mol Med,2002, 34(2):159-166.
15 Lim DS, Bae SM, Kwak SY. Adenovims-mediated p53 treatment enhances photodynamic antitumor response. Hum Gene Ther,2006, 17(3):347-352.
16 Kim JW, Kim TE, Kim YK, et al. Antisense oligodeoxynucleotide of glyceraldehyde-3-phosphate dehydrogenase gene inhibits cell proliferation and induces apoptosis in human cervical carcinoma cell lines. Antisense Nucleic Acid Drug Dev, 1999, 9(6):507-513.
17 Kubota H, Suzuki T, Lu J Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines. Int J Radiat Biol, 2005, 81(9):701-709.
18 Huh JJ, Wolf JK, Fightmaster DL, et al. Transduction of adenovires-mediated wild-type p53 after radiotherapy in human cervireal cancer cells. Gynecol Oncol, 2003, 89(2):243-250.
19 Das S, Somasundaram K. Therapeutic potential of an adenovirus expressing p73beta, a p53 homologue, against human papilloma virus positive cervical cancer in vitro and in vivo. Cancer Biol Ther, 2006, 5(2):210-217.
20 Huh WK, Gomez NJ, Ararat WO, et al. Bax-induced apop-tosis as a novel genetherapy approach for carcinoma of the cervix. Gynecol Oncol, 2001, 83(2):370-377.
21 Ararat WO, Gomez N J, Xiang J, et al. An adenovirus encoding proapoptofic Bax induces apoptosis and enhances the radiation effect in human ovariancancer. Mol Ther, 2000, 1(6):545-554.

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备注/Memo

备注/Memo:
收稿日期:2006-03-17。
更新日期/Last Update: 1900-01-01