[1]王芹.X射线修复交叉互补基因功能的研究进展[J].国际放射医学核医学杂志,2005,29(3):132-136.
　WANG Qin.The recent advance in identification and functions of X ray repair cross complementing genes[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(3):132-136.
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X射线修复交叉互补基因功能的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第3期
页码:
132-136
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The recent advance in identification and functions of X ray repair cross complementing genes
作者:
王芹
300192 天津, 中国医学科学院协和医科大学放射医学研究所
Author(s):
WANG Qin
Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
X射线修复交叉互补基因; 碱基切除修复; 同源重组修复; 非同源末端重接
Keywords:
X ray repair cross complementing genes; base excision repair; homologous recombination repair; non-homologous end joining
分类号:
Q345.7
摘要:
对X射线修复交叉互补(XRCC)基因功能的研究极大地促进了对哺乳动物DNA损伤修复过程和遗传不稳定性致癌机制的理解。通过观察XRCC基因突变体的表型,可以对其功能进行鉴定。目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。XRCC基因的鉴定及其在DNA损伤修复和维持遗传稳定性过程中发挥重要的作用。
Abstract:
The researches on functions of X ray repair cross complementing(XRCC) genes had promoted the understanding of DNA damage repair processes and the mechanism of cancer induced by genetic instability. The functions of XRCC genes could be identified by studying their mutant phenotypes. Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. The identification of XRCC genes and their functions took important parts in DNA damage repairs and genetic stability processes.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-03-30。
更新日期/Last Update: 1900-01-01