[1]苏文娜,蒋铭敏.DHEA及其代谢产物AED和AET的辐射防护作用[J].国际放射医学核医学杂志,2004,28(1):44-46.
　SU Wen-na,JIANG Ming-min.Protection against radiation by dehydroepiandrosterone, androstenediol, and androstenetriol[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(1):44-46.
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DHEA及其代谢产物AED和AET的辐射防护作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第1期
页码:
44-46
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Protection against radiation by dehydroepiandrosterone, androstenediol, and androstenetriol
作者:
苏文娜;  蒋铭敏
100850 北京, 军事医学科学院情报研究所
Author(s):
SU Wen-na;  JIANG Ming-min
Institute of Medical Information, Academy of Military Medical Science, Beijing 100850, China
关键词:
脱氢表雄酮; 雄烯二醇; 雄烯三醇; 辐射防护
Keywords:
dehydroepiandrosterone; androstenediol; androstenetriol; radiation protection
分类号:
R818.05
摘要:
脱氢表雄酮(dehydroepiandrosterone, DHEA)是人体内多种激素合成的前体,有研究表明,DHEA开辟了通过调节免疫系统抗致死性感染的途径,其代谢产物雄烯二醇(androstenediol,AED)和雄烯三醇(androstenetriol,AET)具有更强的抗病毒和细菌感染的能力,降低机体的发病率和死亡率。
Abstract:
Dehydroepiandrosterone(DHEA) was considered to be a biologically irrelevant interme-diate in the pathway of steroid hormones.DHEA provides one of the first avenues by which the im-mune system can be globally regulated to increase resistance to a variety of lethal infections.The downstream metabolites of DHEA particularly androstenediol(AED) and androstenetriol(AET) were sig-nificantly more efficacious at preventing morbidity and mortality associated with viral and bacterial in-fection.

参考文献/References:

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[8] Whitnall MH, Elliott TB, Harding RA, et al. Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice[J]. Iht J Immunopharmacol,2000, 22(1):1-14.
[9] Karishma KK, Herbert J. Dehydroepiandrosterone (DHEA)stimulates neurogenesis in the hippocarnpus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression[J]. Eur J Neurosci, 2002, 16(3):445-453.
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备注/Memo

备注/Memo:
收稿日期:2003-08-06。
更新日期/Last Update: 1900-01-01