[1]李廷.CD40L、IL-10和IL-17的辐射防护作用[J].国际放射医学核医学杂志,2003,27(3):132-134.
　LI Ting.The role of CD40L、 IL-10 and IL-17 in radioprotection[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(3):132-134.
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CD40L、IL-10和IL-17的辐射防护作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第3期
页码:
132-134
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The role of CD40L、 IL-10 and IL-17 in radioprotection
作者:
李廷
215007 苏州, 苏州大学生物技术研究所
Author(s):
LI Ting
Bio-technology Institute, Suzhou University, Suzhou 215007, China
关键词:
CD40配体; 白细胞介素17; 白细胞介素10; 辐射防护
Keywords:
CD40 ligand; interleukin-10; interleukin-17; radioprotection
分类号:
Q691.9
摘要:
CD40L(CD40配体)作为重要的共刺激分子,与CD40(白细胞分化抗原40)相互作用参与机体细胞和体液免疫调节,并在免疫应答中起着极其重要的作用。IL-17(白细胞介素17)可诱导IL-6(白细胞介素6)和G-CSF(粒细胞集落刺激因子)等细胞因子的产生,从而刺激造血祖细胞(CD34+)增殖、分化。IL-10(白细胞介素10)可干扰共刺激分子的上调,抑制免疫刺激因子(如IL-12)的产生,用抗IL-10单抗可阻断紫外线诱导的免疫抑制。简要介绍了CD40L、IL-17和IL-10在
Abstract:
CD40L/CD40 interaction is central to the control of thymus-dependent humoral immunity and cell mediated immune responses. IL-17 has been shown to induce the production of IL-6 and G-CSF, which can induce proliferation and differentiation of CD34+ hematopoietic progenitors. IL-10 can interfere with up-regulation of costimualtory molecules, thus suppressing the production of costimulatory cytokines, such as IL-12. IL-10 has been implicated as an essential mediator in the induction of systemic immune suppression following ultraviolet (UV) exposure. Treating UV-irradiated mice with anti-IL-10 blocks the induction of immune suppression.

参考文献/References:

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[7] Shreedhar V, Giese T, Sung VW, et al. A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression[J]. J Immunol, 1998,160:3782-3789.
[8] Neta R and Durum SK. Modulation by cytokines of damageinduced by ionizing radiation[J]. DNA Damage and Repair, 1996,2:587-601.
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备注/Memo

备注/Memo:
收稿日期:2002-10-08。
基金项目:国家863计划资助项目(2001AA215341)
作者简介:李廷(1976-),男,硕士研究生,主要从事辐射与免疫学的研究。
更新日期/Last Update: 1900-01-01