[1]雷呈志.瘦素和体重调节反馈模式的研究[J].国际放射医学核医学杂志,2002,26(2):60-63.
　LEI Cheng-zhi.Studies on leptin and its feedback system for weight regulation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(2):60-63.
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瘦素和体重调节反馈模式的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第2期
页码:
60-63
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Studies on leptin and its feedback system for weight regulation
作者:
雷呈志
300192 天津, 中国医学科学院放射医学研究所
Author(s):
LEI Cheng-zhi
Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China
关键词:
瘦素; 神经肽Y; 前阿片黑色皮质素
Keywords:
leptin; neuropeptideY; pro-opiomelanocortin
分类号:
R446.6
摘要:
瘦素(Leptin)被认为是一种外周组织反映脂肪量的信号,反馈作用于中枢神经系统。近年来,瘦素的负反馈系统已被部分揭示。下丘脑调节食欲和代谢的中枢受多种分子的协同作用,包括瘦素、神经肽Y(NPY),前阿片类黑色素原(POMC)等。根据已有的对瘦素的理解,建立一个关于瘦素负反馈的模型,可加深了解体内食欲和能量平衡调节机制。
Abstract:
Recently the hormone leptin has been regarded as hormonal signal linking adipose tissue status with a number of key central nervous system circuits. The role of leptin and its feedback system in man is partly revealed. Hypothalamic centers appear to control appetite, metabolic rate and activity level in a coordinate manner. Within the hypothalamus, known weight regulatory molecules include leptin, neuropeptide Y and POMC. We integrated new information into a revised model for understanding this important regulatory process. Our model of energy homeostasis propose that the inter-action of leptin with various neuroendocrine pathway in the brain and in the periphery to affect food-take.

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备注/Memo

备注/Memo:
收稿日期:2002-1-27。
作者简介:雷呈志(1973-),男,山西太原人,山西医科大学第一医院住院医师,影像与核医学专业硕士研究生,主要从事激素检测的临床应用研究。
更新日期/Last Update: 1900-01-01