[1]王明芳.放射性示踪剂在脑功能PET显像中的应用[J].国际放射医学核医学杂志,2001,25(6):246-249.
　WANG Ming-fang.Positron-emitting tracers in brain functional PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(6):246-249.
点击复制

放射性示踪剂在脑功能PET显像中的应用(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第6期
页码:
246-249
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Positron-emitting tracers in brain functional PET
作者:
王明芳
510515 广东 广州, 第一军医大学南方医院PET中心
Author(s):
WANG Ming-fang
Nanfang PET center, Nanfang Hospital, First Military Medical University, Guangdong Guangzhou 510515, China
关键词:
血容量; 血流量; 代谢; 受体; 正电子放射性药物; 正电子发射断层显像; 脑
Keywords:
cerebral blood volume; regional cerebral blood flow; metabolism; receptor; positron-emitting tracer; positron emission tomography; brain
分类号:
R817.4
摘要:
脑PET显像是利用正电子示踪剂检测脑血流量,血容量,局部葡萄糖利用率,氧、氨基酸代谢和血脑屏障的完整性,以及受体的位置、密度和分布等。因此,PET不仅能研究各种脑疾病的过程和特征,评价神经系统疾病治疗效果,而且能研究正常脑功能。
Abstract:
Positron emission tomography (PET) with positfon-emitting tracers can provide the biochemical information which is obtained from the measurement of cerebral blood volume (rCBV),regional cerebral blood flow (rCBF) and/or integrality of the blood-brain barrier, regional cerebral glucose utilize rate, oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (rCMRO 2), and of amino acids (rCMRaa), and the site, density and distribution of the receptors. Thus,PET imaging can investigate the physiochemical process and characteristic of brain diseases and consequently insights concerning the evaluation of disease states, response to therapy, and prognostic indicators.

参考文献/References:

[1] Black KL, Cloughesy T, Huang SC, et al.Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas[J].J Neurosurg, 1997, 86(4):603-609.
[2] Saha GB, MacIntyre WJ, Go RT.Cyclotrons and positron emission tomography radiopharmaceuticals for clinical imaging[J].Semin Nucl Med, 1992, 22(3):150-161.
[3] Saha GB, MacIntyre WJ, Go RT.Radiopharmaceuticals for brain imaging[J].Semin Nucl Med, 1994, 24(4):324-349.
[4] Beason-Held LL, Desmond RE, Herscovitch P, et al.Bolus injection versus slow infusion of [15O]water for positron emission tomography activation studies[J].J Cereb Blood Flow Metab, 1999, 19(8):843-852.
[5] Herscovitch P, Raichle ME, Xilbourn MR, et al.Positron emission tomographic measurement of cerebral blood flow and permeability-surface area product of water using [15O]water and [11C]butanol[J].J Cereb Blood Flow Metab, 1987, 7:527-542.
[6] Herholz K, Holzer T, Schroder R, et al.11C-methionine PET for differential diagnosis of low-grade gliomas[J].Neurology, 1998, 50(5):1316-1322.
[7] Kaschten B, Stevenaert A, Sadzot B, et al.Deprez-M;Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine[J].J Nucl Med, 1998, 39(5):778-785.
[8] Coleman RE, Hoffman JM, Hanson MW et al.Clinical application of PET for the evaluation of brain tumors[J].J Nucl Med, 1991, 32:616-622.
[9] Mineura K, Sasajima T, Kowada M, et al.Indications for differential diagnosis of nontumor central nervous system diseases from tumors.A positron emission tomography study[J].J Neuroimag, 1997, 7(1):8-15.
[10] Cohen RM, Carson RE, Aigner TG, et al.Opiate receptor avidity is reduced in on-motor impaired MPTP-lesioned rhesus monkeys[J].Brain Res, 1998, 806(2):292-296.
[11] Wagner HN.A brief history of positron emission tomography (PET)[J].Semin Nucl Med, 1998, 28(3):213-220.
[12] Meltzer CC, Zubieta JK, Links JM, et al.MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution[J].J Cereb Blood Flow Metab, 1996, 16(4):650-658.
[13] Villemagne VL, Frost JJ, Dannals RF, et al.Comparison of [11C]diprenorphine and [11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system[J].Eur J Pharmacol, 1994, 257:195-197.
[14] Telang FW, Volkow ND, Levy A, et al.Distribution of tracer levels of cocaine in the human brain as assessed with averaged[11C] cocaine images[J].Synapse 1999, 31(4):290-296.

备注/Memo

备注/Memo:
收稿日期:2001-3-28。
作者简介:王明芳(1963-),男,甘肃天水人,广州第一军医大学南方医院PET中心主治医师,讲师,主要从事正电子成像、放射性药物合成的研究。
更新日期/Last Update: 1900-01-01