[1]赵明辉.瘦素应用于肥胖症研究[J].国际放射医学核医学杂志,2001,25(5):193-198.
　ZHAO Ming-hui.Studies on leptin utilizing to obesity[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(5):193-198.
点击复制

瘦素应用于肥胖症研究(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第5期
页码:
193-198
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Studies on leptin utilizing to obesity
作者:
赵明辉
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
ZHAO Ming-hui
Institute of Radiation Medicine, Chinese Academy of Medinal Science Peking Uunion Medical College, Tianjin 300192, China
关键词:
瘦素; 肥胖症; 肥胖基因; 体重指数; 放射免疫分析
Keywords:
leptin; obesity; obese gene; body mass index; radioimmunoassay
分类号:
R446.6
摘要:
瘦素(leptin)是脂肪细胞合成和分泌的一种激素,是肥胖(ob)基因表达的产物,有抑制食欲、促进能量消耗的生理作用。多数研究表明,瘦素是脂肪分解和合成代谢的一个主要调节因子(负反馈),其水平的变化在临床上可作为早期高血脂症、脂肪肝等脂肪代谢率紊乱的灵敏指标。放射免疫分析(RIA)法对人血清(血浆)瘦素水平的精确测定和进一步研究表明,循环瘦素水平与体重指数(BMI)、年龄、性别、性激素及胰岛素内分泌等因素有关,特别是与BMI显著相关,提示多数肥胖个体存在瘦素抵抗。部分瘦素相对缺乏的肥胖者将有可能成为瘦素治疗的对象。瘦素的发现和应用使肥胖症及Ⅱ型糖尿病等相关疾病的研究进入了一个新阶段。
Abstract:
Leptin is a hormone synthesized and secreted by lipid cells.It is a product encoded and expressed by the obese gene. Administration of recombinant leptin decreases food intake,increases energy expenditure and promotes weight loss. Most studies indicate that leptin is a main regulating factor of catabolism and anabolism of adipose tissue. The circulating leptin level is a sensitive index which indicates the confusion of the rate of lipid metabolism such as hyperlipemia, lipoliver and so on.The human leptin radioimmunoassay has been developed to quantitate human leptin in plasma or serum, and to further investigate the relationship between serum leptin concentration and body fat, gender,age,sexual hormones, endocrine of insulin, etc. Especially, serum leptin concentrations are correlated with body-mass-index (BMI),suggesting that most obese persons are resistant to leptin; Those who are relatively deficient of leptin may become the good candidates of leptin treatment in the future.The discovery and application of leptin make the study of obesity,non-insulin dependent diabetes and other correlation diseases enter a new stage.

参考文献/References:

[1] Haffner SM, Miettinen H, Mykkanen L, et al. Leptin concentrations and insulin sensitivity in normoglycemic men[J]. Int J Obes Relat Metab Disord, 1997, 21, 393-399.
[2] Toth MJ, Gottlieb SS, Fisher ML, et al. Plasma leptin concentrations and energy expenditure in heart failure patients[J]. Metabolism, 1997, 46:450-453.
[3] Halaas JL, Gagiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene[J]. Science, 1995, 269:543-546.
[4] Zhang Y, Proenca P, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature, 1994, 372:425-432.
[5] Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor ob-r[J].Cell, 1995, 83:1263-1271.
[6] Pelleymounter MA, Cullen MH, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice[J]. Science, 1995, 269:540-543.
[7] Anon. Leptin:The Fat Homone[EB/OL]. http://www.uitranet.com/jkimball/BiologyPage/L/Leptin/991104.html, 2000-08-28.
[8] Lonngvist F, Amer P, Nordfors L, et al. Over-expression of the obese gene in adipose tissue of human obese subjects[J]. Nature Med, 1995, 1:950-953.
[9] Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normalweight and obese humans[J]. N Engl J Med, 1996, 334:292-295.
[10] Considine RV. Evidence against either a premature stop coden or the absences of obese gene mRNA in human obesity[J]. J Clin Invest, 1995, 95:2986-2988.
[11] Ma Z, Gingerich RL, Santiago JV, et al. Radioimmunoassay of leptin in human plasma[J]. Clin Chem, 1996, 42:942-946.
[12] Friedman. Resistance toleptin contributes to obesity[EB/OL]. http://www.rockfeller.edu/pubinfo/leptin-resistnr.html, 2000-08-28.
[13] Masuzaki H, Ogawa Y, Lsse N, et al. Human obese gene expression, A dipocyte-specific expression and regional differences in the adipose tissue[J]. Diabetes, 1995, 44:855-858.
[14] Bymes SE. Leptin and total cholesterol are predictors of weight gain in pre-pubertal children[J]. Int J Obes Relat Metab Disord, 1999, 23(2):146-150.
[15] Ostlund RE JR, Yang JW, Klein S, et al. Relation between plasma leptin concentration and fat, gender, diet, age and metabolic covariance[J]. J Clin Endocrinol Metab, 1996, 81:3909-3913.
[16] Ahren B, Mansson S, Gingerrich RL, et al. Regulation of plasma leptin in mice:influence of age, high-fat diet, and fasting[J]. Am J Physiol 1997;273:113-120.
[17] Speakman JR. Effects of leptin on food intake and energy expenditure[EB/OL]. http://www.abdn.ac.uk/zoology/nutrition/Leptin.html, 2000-08-28.
[18] Anon. Leptin RIA[EB/OL]. http://www.endosci.com/Literature/Leptin.RIA/html, 2000-08-28.
[19] Campfield LH, Smith FJ, Guisez Y, et al. Recombinant mouse ob protein:evidence for a perpheral signal linking adiposity and central neural network[J]. Science, 1995, 269:546-549.
[20] Maffei M, Halaas J, Ravussin E, et al. Lepin levels in human and rodent:measurement of plasma leptin and ob RNA in obese and weight-reduced subjects[J]. Nature Med, 1995, 1(11):1155-1161.
[21] Dotsch J, Amelmann M, Englaro P, et al. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid[J]. J Neurol Sci, 1997, 151:185-188.
[22] Sharon D. New technique to measure leptin activity[EB/OL]. http://www.ars.usda.gov/is/pr/2000/000508.html, 2000-08-28.
[23] First report of successful weight loss in human with leptin[EB/OL]. http://www.diabetes.org/am98/annualMeeting/pressroom/leptin.asp, 1998-12-28.
[24] Campfield LA, Smith FJ, Brun P, et al. Strategies and potential molecular targets for obesity treatment[J].Science, 1998, 28:1383-1387.
[25] Anon. Human leptin RIA kit[EB/OL]. http://Lincoresearch.com/protocols/frames/prot-hl-81k.html, 2000-08-15.

相似文献/References:

[1]陈晓毓,李希圣,林夏鸿,等.肥胖患者脂联素基因第45位点单核苷酸多态性与血浆脂联素水平及胰岛素抵抗的相关性研究[J].国际放射医学核医学杂志,2012,36(5):269.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.003]
　CHEN Xiao-yu,LI Xi-sheng,LIN Xia-hong,et al.Association of single nucleotide polymorphism at position 45 in adiponectin gene with plasma adiponectin level and insulin resistance in obesity[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(5):269.[doi:10.3760/cnla.j.issn.1673-4114.2012.05.003]
[2]濮伟刚,谭纪伏,朱建华,等.血浆中四种肿瘤标志物和13C-尿素呼气试验对胃癌诊断的对比研究[J].国际放射医学核医学杂志,2010,34(2):94.[doi:10.3760/cma.j.issn.1673-4114.2010.02.008]
　PU Wei-gang,TAN Ji-fu,ZHU Jian-hua,et al.Clinical application of four plasma tumor markers and 13C-urea breath test in diagnosis of patients with gastric carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):94.[doi:10.3760/cma.j.issn.1673-4114.2010.02.008]
[3]王金萍,吴秋莲,徐浩.甲状腺功能与血清饥饿素和瘦素水平的相关陛研究[J].国际放射医学核医学杂志,2008,32(4):221.
　WANG Jin-Lian,WU Qiu-lion,XU Hao.Association of thyroid function with human serum ghrelin and leptin levels[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):221.
[4]朱文茹,左书耀.瘦素的表达与肿瘤的关系[J].国际放射医学核医学杂志,2005,29(4):164.
　ZHU Wen-Ru,ZUO Shu-Yao.Relationship between leptin expression and tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):164.
[5]雷呈志.瘦素和体重调节反馈模式的研究[J].国际放射医学核医学杂志,2002,26(2):60.
　LEI Cheng-zhi.Studies on leptin and its feedback system for weight regulation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(5):60.

备注/Memo

备注/Memo:
收稿日期:2001/3/26。
作者简介:赵明辉(1971-),男,辽宁北镇人,中国医学科学院中国协和医科大学放射医学研究所助理研究员,硕士研究生,主要从事免疫药盒的研制开发与生产。
更新日期/Last Update: 1900-01-01