[1]孙元明.用荧光原位杂交对早先受照者剂量验证和剂量重建的探讨[J].国际放射医学核医学杂志,2001,25(3):134-137.
　SUN Yuan-ming.The possibility of dose verification and reconstruction of the early exposure by fluorescence in situ hybridization[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(3):134-137.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第3期
页码:
134-137
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The possibility of dose verification and reconstruction of the early exposure by fluorescence in situ hybridization
作者:
孙元明
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
SUN Yuan-ming
Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China
关键词:
荧光原位杂交; 早先受照者; 剂量重建
Keywords:
fluorescence in situ hybridization; early exposuer; dose reconstruction
分类号:
R144.1
摘要:
介绍了近年来用荧光原位杂交技术研究早先受照者的辐射生物剂量方法学和体外剂量效应关系曲线的研究,探讨了国外应用该技术对早先受照者剂量重建和验证的研究。荧光原位杂交将为人们研究早先受照者染色体损伤和剂量重建提供一个新的手段。
Abstract:
The paper introduces biological dose reconstruction methodology of the early exposuer and studies on dose response curve in vitro by FISH in recent years and comments the possibility of the technical application to victims’dose verification and reconstruction in abroad. FISH will become a new approach to analyze chromosome aberration and dose reconstruction for early exposure.

参考文献/References:

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[2] Xiao Y,Natarajan AT.Non-proportional involvement of Chinese hamster chromosomes 3,4,8 and 9 in X-ray-induced chromosomal aberrations[J].Int J Radiat Biol,1999,75(8):943-951.
[3] Hsieh W A,Deng W,Chang W P,et al.Alpha coeffi-cient of dose-response for chromosome translocations measured by FISH in human lymphocytes exposed to chronic 60Co gamma rays at body temperature[J].Int J Radiat Biol,1999,75(4):435-439.
[4] Finno P,Lioyd DC,Edwards AA.Fluorescence in situ hybridization detection of chromosome aberrations in human lymphocytes:applicability to biological des-imetry[J].Int J Radiat Biol,1995,68(4):429-435.
[5] Lindholm C,Luomahaara S,Koivistoinen A,et al.Comparison of dose-response curves for chromosomal aberrations established by chromosome painting and conventional analysis[J].Int J Radiat Biol,1998,74(1):27-34.
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[7] Bauchinger M.Retrospective dose reconstruction of human radiation exposure by FISH/chromosome paint-ing[J].Mutat Res,1998,404(1-2):89-96.
[8] Bothwell AM,Whitehouse CA,Tawn EJ.The appli-cation of FISH for chrcmosome aberration analysis in relation exposure[J].Radiat Protect Dosi,2000,88(1):7-14.
[9] Moquet JE,Edwards AA,Lloyd DC,et al.The use of FISH chromosome painting for assessment of old dose of ionizing radiation[J].Radiat Protect Dosim,2000,88(1):27-33.
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[11] Snigiryova G,Braselmann H,Salassidis D,et al.Ret-rospective bidosimetry of Chernobyl clean-up worker using chromosome painting and conventional chromo-some analysis[J].Int J Radiat Biol,1997,71(2):119-127.
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[13] Lloyd DC,Moquet JE,Oram S,et al.Accidental in-take of tritiated water:a cytogenetic follow-up case on translocation stability and dose reconstruction[J].Int J Radiat Biol,1988,73(5):543-547.

相似文献/References:

[1]王晓琳,王知权.荧光原位杂交技术作为辐射生物剂量计的可行性研究[J].国际放射医学核医学杂志,1999,23(1):30.
[2]王知权,金璀珍.染色体畸变分析作为辐射生物剂量计的最新进展[J].国际放射医学核医学杂志,1999,23(3):109.

备注/Memo

备注/Memo:
收稿日期:2001/2/19。
基金项目:中国医学科学院中国协和医科大学院校基金(952060)
作者简介:孙元明(1962-),男,辽宁鞍山人,中国医学科学院放射医学研究所副研究员,主要从事放射生物学研究。
更新日期/Last Update: 1900-01-01