[1]庄永志,王俊杰.射线对血管平滑肌细胞抑制作用的机制[J].国际放射医学核医学杂志,2001,25(1):27-30.
　ZHUANG Yong-zhi,WANG Jun-jie.Mechanisms of radiation for the inhibition of vascular smooth musele cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):27-30.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第1期
页码:
27-30
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Mechanisms of radiation for the inhibition of vascular smooth musele cells
作者:
庄永志;  王俊杰
100083 北京, 北京大学第三医院肿瘤治疗中心
Author(s):
ZHUANG Yong-zhi;  WANG Jun-jie
Department of Oncology, the Third Hospital of Beijing University, Beijing 100083, China
关键词:
血管内照射; 再狭窄; 平滑肌细胞; 经皮穿刺冠状动脉成形术
Keywords:
endovascular radiotherapy; restenosis; vascular smooth muscle cells; percutaneous transluminal coro-nary angioplasty
分类号:
Q274
摘要:
血管腔内放疗预防经皮穿刺冠状动脉血管成形术(PTCA)后再狭窄的临床应用取得了令人瞩目的疗效。人们认为,射线预防PTCA后血管再狭窄主要是射线对血管平滑肌细胞产生的抑制作用,但是这种抑制作用的机制尚不十分清楚,目前认为最关键的因素是射线抑制了血管平滑肌细胞的迁移和增殖,凋亡在射线抑制再狭窄过程中所起的作用尚存在争议。在这个过程中,射线对巨噬细胞和多种细胞因子的抑制作用也逐步受到人们的重视。
Abstract:
Endovascular radiation is a promising technique to substantianlly reduce the restenosis post-PTCA. Inhi-bition of VSMCs by radiation is thought as the main cause, but the machanism of this is not clear. Inhibition of VSMCs proliferation and miagration by radiation is ragarded as the most important factor. The role of apoptosis in this couse is not determined. However, inhibition of macrophage and cytokines by radiation is emphasized recently.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2000/12/14。
基金项目:国家自然科学基金资助项目(39900167)
作者简介:庄永志(1972-),男,黑龙江大庆人,大庆油田总医院主治医师,现为北京大学第三医院肿瘤治疗中心硕士研究生(委托培养),主要从事射线抑制再狭窄的细胞和分子生物学机制研究。;王俊杰(1964-)男,内蒙古乌兰浩特人,北京大学第三医院肿瘤治疗中心副主任医师,硕士,主要从事射线抑制再狭窄的细胞和分子生物学机制,肿瘤粒子种植治疗的研究。
更新日期/Last Update: 1900-01-01