[1]王淑侠,裴著果.延迟相心肌缺血预适应机制的核医学方法研究[J].国际放射医学核医学杂志,2001,25(1):1-3.
　WANG Shu-xia.Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):1-3.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第1期
页码:
1-3
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning
作者:
王淑侠;  裴著果
110001 辽宁沈阳, 中国医科大学附属第二临床学院核医学科
Author(s):
WANG Shu-xia
Department of Nuclear Medicine, No.2, Affiliated Hospital, China Medical University, Liaoning, Shengyang 110001, China
关键词:
缺血预适应; 心肌; 3H-亮氨酸; 单光子发射断层显像; 正电子发射断层显像
Keywords:
ischemic preconditioning; myocardial; 3H-leucine; single photon emission computerized tomgraphy; positron emission tomography
分类号:
R817.4
摘要:
心肌缺血预适应是目前已知心脏保护作用最为强大的、心脏固有的自我保护机制,阐明预适应机制是临床合理安全地利用预适应保护作用的前提。延迟相预适应机制目前主要有NO(一氧化氮)假说、自由基机制、保护性蛋白的作用和ATP敏感性钾通道作用等。引入3H-亮氨酸,利用液闪技术,已直接从因果关系上证实保护性蛋白在预适应保护中的作用。利用SPECT可无损伤地在活体内显示预适应心肌特点,而PET则可进行预适应心肌代谢改变与心功能关系的研究。
Abstract:
Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation 3H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.

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备注/Memo

备注/Memo:
收稿日期:2000/9/4。
作者简介:王淑侠(1965-)女,辽宁沈阳人,中国医科大学第二临床学院核医学科博士研究生,主要从事核心脏病学研究。
更新日期/Last Update: 1900-01-01