[1]胡四龙.11C-flumazenil PET对癫痫灶定位诊断的价值[J].国际放射医学核医学杂志,2000,24(6):249-254.
 HU Silong.The evaluation of 11C-flumazenil PET in the localisation of epileptic foci[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(6):249-254.
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11C-flumazenil PET对癫痫灶定位诊断的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第6期
页码:
249-254
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The evaluation of 11C-flumazenil PET in the localisation of epileptic foci
作者:
胡四龙
200040 上海, 复旦大学医学院附属华山医院核医学科
Author(s):
HU Silong
Department of Nuclear Medicine, Huashan Hospital, Medical Center of Fudan University, Shanghai, China
关键词:
癫痫灶11碳-氟马西尼正电子发射断层显像中枢型苯二氮受体
Keywords:
epilpsy focus11C-flumazenilpositron emission tomographycentral benzodiazepine receptor(cBZR)
分类号:
R817.4
摘要:
11C-flumazenil(11C-FMZ)PET所测量到的局部脑区中枢型苯二氮受体(cBZR)密度降低是癫痫灶的特异性生化改变的标志,对癫痫灶定位的灵敏度和准确性高,明显优于EEG(脑电图)、MRI、18F-FDG PET(18F-氟代脱氧葡萄糖)等方法。
Abstract:
the density of central benzodiazepine (cBZR) receptor is significanly reduced in epileptic foci and it is regdarded as the specific biochemical marker of epileptic foci.11C-flumazenil PET can measure the cBZR desity and is superior to MRI and 18F-FDG in accurate presurgical identification of epileptic foci.

参考文献/References:

[1] Loscher W.Basic aspects of epilepsy[J].Curr Opin Neurphysiol, 1993, 6:223-232.[2] Gloor P.Epilepsy:relationships between electrophysiology and intracellular mechanisms involving second messengers and gene expression[J].Can J Neurol Sci, 1989, 16:8-21.[3] Savic I, Widen L, Thorell JO, et al.Cortical benzodiazepine receptor binding in patients with generalized and partial epilepsy[J].Epilepsia, 1990, 31:724-730.[4] Savic I, Pauli S, Thorell JO, et al.In vivo demonstration of altered benzodiazepine receptor desity in patients with primary generalized epilepsy[J].J Neurol Neurosurg Psychiatr, 1994, 57:797-804.[5] Koepp MJ, Richardson MP, Brooks DJ, et al.Central benzodiazepine/gama-aminobutyric acid receptors in idiopathic generalized epilepsy:an [11C] flumazenil positron emission tomography study[J].Epilepsia, 1997, 38:1089-1097.[6] Prevett MC, Lammertsma AA, Brooks DJ, et al.Bezodiazepine GABAA receptor binding during absence seizure[J].Epilesia, 1995, 36:592-599.[7] Koepp MJ, Richardson MP, Brooks DJ, et al.Cerebral benzodiazepine receptors in hippocampal sclerosis:An objective in vivo analysis[J].Brain, 1996, 119:1677-1687.[8] Savic I, Persson A, Roland P, et al.In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci[J].Lancet, 1988, 2:861-865.[9] Savic I, Svanborg E and Thorell JO.Cortical benzodiazepine receptor changes are related to frequency of partial seizure:A positron emission tomography study[J].Epilepsia, 1996, 37:236-244.[10] Koepp MJ, Richardson MP, Labbe C, et al.11C-flumazenil PET, volumetric MRI, and quanitative pathology in mesial temporal lobe epilepsy[J].Neurology, 1997, 49:764-773.[11] Savic I, Thorell JO, and Roland P.[11C] Flumazenil positron emission tomography visualizes frontal epileptogenic regions[J].Epilepsia, 1995, 36:1225-1232.[12] Richardson MP, Koepp MJ, Brooks DJ, et al.11C-flumazenil PET in neocotical epilepsy[J].Neurology, 1998, 51:485-492.
[13] Richardson MP, Koepp MJ, Brooks DJ, et al.Benzodiazepine receptors in focal epilepsy with cortical dysgenesis:An 11C-flumazenil PET study[J].Ann Neurol, 1996, 40:188-198.
[14] Savic I, Inguar M, and Stone-Elander S.Comparison of [11C] flumazenil and 18F-FDG as PET markers of epileptic foci[J].J Neuro Neurosurg Psychiatry, 1993, 56:615-621.
[15] Henry TR, Frey KA, Sackellares JC, et al.In vivo cerebral metabolism and central benzodiazepine receptor binding in temporal lobe epilepsy[J].Neurology, 1993, 3:1998-2006.
[16] Szelies B, Weber-Luxenburger G, Pawlik G, et al.MRI-guied flumazenil-and FDG-PET in temporal lobe epilepsy[J].Neuroimage, 1996, 3:109-118.
[17] Debets RM, Sadzot B, Van Isset JW, et al.Is [11C-] flumazeni1 PET superior to 18F-FDG PET and 123I-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy?[J].J Neuro Neurosurg Psychiatry, 1997, 62:141-150.
[18] Koepp MJ, Labbe C, Richardson MP, et al.Regional hippocampal[11C] flumazenil PET in temporal lobe epilpsy with unilateral and bilateral hippocampal sclerosis[J].Brain, 1997, 120:1865-1876.
[19] Ryvlin P, Bouvard S, Bars L, et al.Clinical utility of flumazenil PET versus[18F] fluorodeoxyglucose PET and MRI in refractory partial epilepsy[J].Brain, 1998, 121:2067-2081.
[20] Juhasz C, Nagy F, Muzik O, et al.[11C] Flumazenil PET in patients with epilepsy with dual pathology[J].Epilepsia, 1999, 40:566-574.

备注/Memo

备注/Memo:
收稿日期:2000-03-18。
作者简介:胡四龙(1970-),男,湖北通城人,复旦大学医学院附属华山医院核医学科硕士研究生,主要从事肾脏核医学显像研究。
更新日期/Last Update: 1900-01-01