[1]段晓蓓,陈相猛,黄斌豪,等.18F-FDG PET/CT显像在肾上腺转移瘤中的诊断价值和预测分析[J].国际放射医学核医学杂志,2018,(4):307-311,327.[doi:10.3760/cma.j.issn.1673-4114.2018.04.003]
 Duan Xiaobei,Chen Xiangmeng,Huang Binhao,et al.18F-FDG PET/CT diagnostic value and predictive analysis in adrenal metastasis lesions[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(4):307-311,327.[doi:10.3760/cma.j.issn.1673-4114.2018.04.003]
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18F-FDG PET/CT显像在肾上腺转移瘤中的诊断价值和预测分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
期数:
2018年第4期
页码:
307-311,327
栏目:
临床研究
出版日期:
2018-07-25

文章信息/Info

Title:
18F-FDG PET/CT diagnostic value and predictive analysis in adrenal metastasis lesions
作者:
段晓蓓1 陈相猛2 黄斌豪1 邹伟强1 秦贵磷1 吴月娥1
1. 529070, 中山大学附属江门医院核医学科;
2. 529070, 中山大学附属江门医院放射科
Author(s):
Duan Xiaobei1 Chen Xiangmeng2 Huang Binhao1 Zou Weiqiang1 Qin Guilin1 Wu Yue’e1
1. Department of Nuclear Medicine, the Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen 529070;
2. Department of Radiology, the Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen 529070, China
关键词:
肾上腺疾病肿瘤转移正电子发射断层显像计算机体层摄影术氟脱氧葡萄糖F18
Keywords:
Adrenal gland diseasesNeoplasm metastasisPositron emission tomography computed tomographyFluorodeoxyglucose F18
DOI:
10.3760/cma.j.issn.1673-4114.2018.04.003
摘要:
目的 探讨18F-FDG PET/CT显像在肾上腺转移瘤中的诊断价值及预测价值。方法 回顾性分析2012年12月至2016年10月行PET/CT检查的95例无症状的肾上腺病变患者,分为肾上腺转移瘤组(40例)和肾上腺良性病变组(55例),分别测量肾上腺病灶大小、CT值、最大标准化摄取值(SUVmax)、肾上腺病灶SUVmax/肝脏本底SUVmax比值(SUVmax比值),分别进行单因素检验、独立样本t检验、Mann-Whitney U秩和检验统计分析。采用多因素Logistic回归分析肾上腺转移瘤的危险预测因素,并采用受试者工作特征(ROC)曲线分析确定肾上腺转移瘤与良性病变鉴别诊断的最佳临界点。结果 110个肾上腺病灶中良性病变60个,转移瘤50个,大小为0.65~5.70 cm,平均(1.65±0.82)cm。CT值-20.4~46.8 HU,平均(24.2±14.9)HU。SUVmax为1.1~31.9,平均4.5±4.6。SUVmax比值为0.44~14.5,平均1.99±2.15。单因素分析得出两者在病灶大小、CT值、SUVmax、SUVmax比值之间的差异均有统计学意义(Z=-4.908、-6.030、-7.966、-8.252,均P<0.001);多因素Logistic回归分析显示SUVmax比值是影响肾上腺转移瘤发生的独立因素,ROC曲线分析得出SUVmax比值=1.24为鉴别诊断肾上腺转移瘤与良性病变的最佳临界点,灵敏度和特异度分别为90.0%和93.3%。结论 18F-FDG PET/CT显像对肾上腺转移瘤具有较高的诊断价值。SUVmax比值是肾上腺转移瘤的独立危险预测因素,鉴别诊断肾上腺良性病变与转移瘤的SUVmax比值最佳临界点为1.24。
Abstract:
Objective To discuss 18F-FDG PET/CT diagnostic value and predictive analysis in adrenal metastasis lesions. Methods A total of 110 adrenal lesions in 95 non-symptom patients who underwent 18F-FDG PET/CT examination were retrospectively analyzed. Patients were divided into adrenal benign group(55 cases) and metastasis group(40 coses). Adrenal lesion size, CT attenuation value, SUVmax(standard uptake value maximum), and SUVmax ratio between adrenal and liver lesions(SUVmax ratio) were measured and recorded for each lesion. Univariate χ2 test, independent sample t-test, and Mann-Whitney U rank test were used for the statistical analyses. Univariate analysis and multivariate logistic analysis were used for the evaluation of predictive risk factor. The author performed ROC(receiver operating characteristic) curve analysis to determine the cut-off value in the diagnosis of adrenal metastasis lesions. Results A total of 110 lesions, 60 benign and 50 metastasis, were detected. The lesions diameter was 0.65 cm~5.70 cm with the average diameter (1.65±0.82) cm; the lesions CT value were -20.4~46.8 HU with the average CT value(24.2±14.9) HU; the lesions SUVmax were 1.1~31.9 with the average SUVmax 4.5±4.6; the lesions SUVmax ratio were 0.44~14.5 with the average SUVmax ratio 1.99±2.15. Differences in size, CT attenuation value, SUVmax, and SUVmax ratio between the benign and adrenal metastasis lesions were statistically significant(Z=-4.908, -6.030, -7.966, -8.252, respectively; all P<0.001). The SUVmax ratio was the independent risk factor of adrenal metastasis. The SUVmax ratio of 1.24 was the best cutoff in the ROC analysis, yielding a sensitivity of 90.0% and specificity of 93.3%. Conclusions 18F-FDG PET/CT is valuable in diagnosing adrenal metastasis lesions. The adrenal-to-liver SUVmax ratio is the independent risk factor of adrenal metastasis, and the SUVmax ratio of 1.24 was the best cutoff in the ROC analysis.

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备注/Memo

备注/Memo:
收稿日期:2018-04-03。
通讯作者:黄斌豪,Email:13702288099@163.com
更新日期/Last Update: 2018-07-25