[1]丛慧,梁军,林岩松.碘难治性分化型甲状腺癌的诊断与靶向治疗[J].国际放射医学核医学杂志,2015,39(1):25-31.[doi:10.3760/cma.j.issn.1673-4114.2015.01.007]
 Cong Hui,Liang Jun,Lin Yansong.Diagnosis and targeted therapy of radioactive iodine-refractory differentiated thyroid cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):25-31.[doi:10.3760/cma.j.issn.1673-4114.2015.01.007]
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碘难治性分化型甲状腺癌的诊断与靶向治疗(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第1期
页码:
25-31
栏目:
出版日期:
2015-01-25

文章信息/Info

Title:
Diagnosis and targeted therapy of radioactive iodine-refractory differentiated thyroid cancer
作者:
丛慧12 梁军2 林岩松1
1. 中国医学科学院北京协和医学院, 北京协和医院核医学科, 北京, 100730;
2. 青岛大学附属医院肿瘤科, 青岛, 266003
Author(s):
Cong Hui12 Liang Jun2 Lin Yansong1
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
关键词:
诊断碘难治性分化型甲状腺癌分子靶向治疗
Keywords:
DiagnosisRadioactive iodine-refractory differentiated thyroid cancerMolecular targeted therapy
DOI:
10.3760/cma.j.issn.1673-4114.2015.01.007
摘要:
近年来甲状腺癌的发病率逐年升高,其中分化型甲状腺癌(DTC)占到了90%以上。一部分DTC可在自然状态下或治疗过程中失分化而发展为碘难治性分化型甲状腺癌(RAIR-DTC)。目前有关RAIR-DTC的定义尚未达成共识,这在一定程度上影响了其诊断与治疗。由于RAIR-DTC的治疗效果欠佳,一直是甲状腺癌的治疗难点。随着对甲状腺癌分子病理学研究的深入,分子靶向药物得到了迅速发展,尤其是其在碘难治性甲状腺癌中的应用取得了明显的效果,为甲状腺癌的治疗开辟了新的方向。
Abstract:
During the last few decades, the incidence of thyroid cancers has been escalating globally, with differentiated thyroid cancer (DTC) accounting for 90% of the cases. A portion of DTC dedifferentiates and becomes radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC),naturally or during cancer management. Currently, no consensus exists regarding the definition of RAIR-DTC, which to a certain extent influences its diagnosis and treatment. RAIR-DTC has always been a problem because its management lacks efficiency. As the understanding on the molecular pathophysiology of thyroid cancer continues to improve, targeted agents develop quickly, particularly in the treatment of RAIR-DTC, which will open up new directions for the management of thyroid cancer.

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备注/Memo

备注/Memo:
收稿日期:2015-01-06。
基金项目:国家自然科学基金(30970850);卫生行业科研专项(201202012)
通讯作者:梁军,Email:liangjun59@126.com;林岩松,Email:linys@pumch.cn
更新日期/Last Update: 1900-01-01