[1]陈海龙,邵小南,王跃涛.高血糖对脑葡萄糖代谢的影响研究[J].国际放射医学核医学杂志,2014,38(5):293-296.[doi:10.3760/cma.j.issn.1673-4114.2014.05.004]
　Chen Hai-long,Shao Xiao-nan,Wang Yue-tao.Influence of the high level of blood glucose on the metabolism of brain glucose[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(5):293-296.[doi:10.3760/cma.j.issn.1673-4114.2014.05.004]
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高血糖对脑葡萄糖代谢的影响研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第5期
页码:
293-296
栏目:
出版日期:
2014-09-25

文章信息/Info

Title:
Influence of the high level of blood glucose on the metabolism of brain glucose
作者:
陈海龙;  邵小南;  王跃涛
常州市第一人民医院核医学科, 213003
Author(s):
Chen Hai-long;  Shao Xiao-nan;  Wang Yue-tao
Department of Nuclear Medicine, the First People’s Hospital of Changzhou, Changzhou 213003, China
关键词:
高血糖症; 脑; 正电子发射断层显像术; 葡萄糖代谢
Keywords:
Hyperglycemia; Brain; Positron-emission tomography; Glucose metabolism
DOI:
10.3760/cma.j.issn.1673-4114.2014.05.004
摘要:
目的 通过比较不同血糖水平人群脑PET图像,分析高血糖对脑葡萄糖代谢的影响。方法 回顾性地分析行全身PET/CT检查发现的血糖增高者236例,按照有无糖尿病史分为两组:高血糖无糖尿病组131例和高血糖有糖尿病组105例;并以血糖增高者的平均年龄±5岁为范围选择血糖正常对照组292例。测量所有受检者的身高、体重,计算体重指数。用Scenium软件进行图像归一化并勾画脑区,得到3组人群各脑区的SUV平均值(SUVmean)后进行分析。结果 高血糖无糖尿病组与高血糖有糖尿病组的体重指数差异无统计学意义(t=0.464,P>0.05),但均高于正常对照组(t=4.742和3.244,P均<0.05);比较3组的各脑区代谢发现,距状裂及周围皮层的代谢水平最高,而内侧颞叶、小脑的代谢水平较低;随着3组间血糖水平的升高,不同脑区SUVmean逐步降低,即:正常对照组>高血糖无糖尿病组>高血糖有糖尿病组。结论 高血糖能降低大脑的葡萄糖代谢水平,有助于临床理解糖尿病脑病的发病机制。
Abstract:
Objective To analyze the influence of the high level of blood glucose on the metabolism of brain glucose by comparing the brain PET images of the groups with different level of blood glucose. Methods Two hundred and thirty-six consecutive patients with high level of blood glucose were divided into two groups by with the history of diabetes mellitus (DM)or not:one hundred and five patients with DM, while one hundred and thirty-one patients without DM. Two hundred and ninety-two healthy people with similar age were selected as a normal control group. All the people were underwent PET/CT imaging. Body mass index (BMI)was counted. The brain imaging was analyzed by the Siemens Scenium software to get and analyze the SUV means (SUVmean)of the brain zones in the three groups. Results The BMI between the two groups with high level of blood glucose has no significant difference (t=0.464, P>0.05), while they were higher than that in the normal control group (t=4.742 and 3.244, both P<0.05). Comparing the cerebral metabolism of the brain zones, the metabolism of calcarine fissure and surrounding cortex were the highest, while the metabolism of mesial temporal lobe and cerebellun were lower. As the blood glucose levels increased, the SUVmean in the normal control group, the high level of blood glucose group (without DM)and the high level of blood glucose (with DM)were gradually decreased. Conclusion High level of blood glucose can reduce the metabolism of glucose in the brain, it can be helpful to investigate the pathogenesis of diabetic encephalopathy.

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备注/Memo

备注/Memo:
收稿日期:2013-11-11。
通讯作者:王跃涛(Email:yuetao-w@163.com)
更新日期/Last Update: 1900-01-01